UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Details

Name
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
Synonyms
  • 3.5.1.-
  • envA
  • Protein EnvA
  • UDP-3-O-acyl-GlcNAc deacetylase
Gene Name
lpxC
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0012863|UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIPARAENVGET
TMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQ
EQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTS
FVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKIL
DAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRPA
AAV
Number of residues
303
Molecular Weight
33434.81
Theoretical pI
5.0
GO Classification
Functions
UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Processes
lipid A biosynthetic process
General Function
Udp-3-o-[3-hydroxymyristoyl] n-acetylglucosamine deacetylase activity
Specific Function
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0012864|UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (lpxC)
ATGATCAAACAACGCACCTTGAAGAACATCATCCGGGCTACTGGCGTCGGTCTGCACTCG
GGGGAAAAGGTTTACCTGACCCTGAAACCGGCGCCGGTGGACACCGGTATCGTGTTCTGC
CGCACCGACCTGGATCCGGTCGTGGAAATCCCGGCCCGGGCCGAGAACGTCGGCGAAACC
ACCATGTCGACCACCCTGGTCAAGGGTGACGTCAAAGTGGATACGGTGGAGCACCTGCTC
TCGGCCATGGCCGGCCTGGGTATCGACAACGCCTACGTCGAGCTGTCCGCTTCGGAAGTG
CCGATCATGGATGGCAGCGCTGGTCCGTTCGTATTCCTGATCCAGTCCGCCGGATTGCAA
GAGCAGGAAGCTGCCAAGAAGTTCATCCGCATCAAGCGCGAAGTCAGCGTGGAAGAGGGC
GACAAGCGCGCCGTCTTCGTTCCGTTCGACGGCTTCAAGGTCAGCTTCGAGATCGATTTC
GATCATCCGGTCTTCCGTGGTCGCACCCAGCAGGCCTCGGTCGATTTCTCCAGTACTTCC
TTCGTCAAGGAGGTCAGCCGCGCCCGTACCTTCGGGTTCATGCGCGACATCGAGTACCTG
CGTTCGCAGAACCTGGCACTCGGCGGTAGCGTGGAGAACGCGATCGTGGTCGACGAGAAC
CGCGTGCTCAACGAAGACGGCCTGCGTTACGAGGACGAGTTCGTCAAGCACAAGATCCTG
GATGCCATCGGCGACCTGTATCTGCTCGGCAACAGTCTTATCGGCGAGTTCCGTGGCTTC
AAGTCCGGCCATGCCCTGAACAACCAACTGCTGCGTACGTTGATCGCAGACAAGGATGCT
TGGGAAGTGGTGACCTTCGAAGACGCGCGTACCGCGCCTATTTCCTATATGCGCCCGGCG
GCGGCAGTGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP47205
UniProtKB Entry NameLPXC_PSEAE
GenBank Protein ID6715617
GenBank Gene IDU19797
General References
  1. Hyland SA, Eveland SS, Anderson MS: Cloning, expression, and purification of UDP-3-O-acyl-GlcNAc deacetylase from Pseudomonas aeruginosa: a metalloamidase of the lipid A biosynthesis pathway. J Bacteriol. 1997 Mar;179(6):2029-37. [Article]
  2. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  3. Liao X, Charlebois I, Ouellet C, Morency MJ, Dewar K, Lightfoot J, Foster J, Siehnel R, Schweizer H, Lam JS, Hancock RE, Levesque RC: Physical mapping of 32 genetic markers on the Pseudomonas aeruginosa PAO1 chromosome. Microbiology. 1996 Jan;142 ( Pt 1):79-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07861(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamideexperimentalunknownDetails