Biphenyl-2,3-diol 1,2-dioxygenase

Details

Name
Biphenyl-2,3-diol 1,2-dioxygenase
Synonyms
  • 1.13.11.39
  • 2,3-dihydroxybiphenyl dioxygenase
  • 23OHBP oxygenase
  • DHBD
Gene Name
bphC
Organism
Burkholderia xenovorans (strain LB400)
Amino acid sequence
>lcl|BSEQ0010914|Biphenyl-2,3-diol 1,2-dioxygenase
MSIRSLGYMGFAVSDVAAWRSFLTQKLGLMEAGTTDNGDLFRIDSRAWRIAVQQGEVDDL
AFAGYEVADAAGLAQMADKLKQAGIAVTTGDASLARRRGVTGLITFADPFGLPLEIYYGA
SEVFEKPFLPGAAVSGFLTGEQGLGHFVRCVPDSDKALAFYTDVLGFQLSDVIDMKMGPD
VTVPAYFLHCNERHHTLAIAAFPLPKRIHHFMLEVASLDDVGFAFDRVDADGLITSTLGR
HTNDHMVSFYASTPSGVEVEYGWSARTVDRSWVVVRHDSPSMWGHKSVRDKAAARNKA
Number of residues
298
Molecular Weight
32470.515
Theoretical pI
5.99
GO Classification
Functions
biphenyl-2,3-diol 1,2-dioxygenase activity / ferrous iron binding
Processes
aromatic compound catabolic process / xenobiotic catabolic process
General Function
Ferrous iron binding
Specific Function
Shows a preference for catechols with groups immediately adjacent to the hydroxyl substituents.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0010915|Biphenyl-2,3-diol 1,2-dioxygenase (bphC)
ATGAGCATCAGAAGTTTGGGATACATGGGGTTTGCGGTCAGCGACGTAGCTGCTTGGCGT
TCGTTTCTGACGCAGAAACTGGGCTTGATGGAAGCGGGCACGACCGACAACGGCGACCTG
TTCCGCATCGATTCGAGAGCCTGGCGGATCGCCGTTCAGCAGGGCGAGGTTGACGATCTG
GCCTTTGCCGGCTACGAGGTGGCCGATGCGGCAGGGCTGGCGCAGATGGCTGACAAGCTC
AAACAGGCCGGTATCGCAGTCACCACCGGCGATGCCTCATTGGCCAGGCGCCGCGGGGTG
ACCGGATTGATCACCTTTGCCGACCCGTTTGGCCTGCCGTTGGAAATTTACTATGGCGCC
AGCGAGGTGTTCGAAAAACCGTTCCTGCCTGGTGCGGCCGTGTCGGGTTTCCTGACCGGC
GAGCAAGGGCTGGGGCATTTCGTGCGCTGCGTTCCGGATTCGGACAAGGCGCTGGCGTTT
TATACCGACGTGCTCGGCTTCCAGTTGTCTGACGTCATCGACATGAAAATGGGGCCGGAC
GTGACGGTTCCTGCGTACTTCCTGCACTGCAACGAACGCCACCACACCCTGGCAATTGCG
GCATTCCCGCTGCCAAAACGCATTCATCACTTCATGCTCGAAGTCGCCTCGCTCGATGAC
GTCGGCTTTGCATTTGATCGGGTTGACGCGGACGGCTTGATCACCTCCACGCTGGGGCGC
CACACCAATGACCACATGGTGTCGTTCTATGCCTCGACCCCGTCCGGAGTAGAGGTCGAG
TATGGCTGGAGTGCCCGTACCGTTGACCGCTCCTGGGTTGTGGTGAGGCACGACAGTCCG
AGCATGTGGGGCCACAAGTCTGTGCGCGACAAAGCAGCTGCGCGCAACAAAGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP47228
UniProtKB Entry NameBPHC_BURXL
GenBank Protein ID397884
GenBank Gene IDX66122
General References
  1. Hofer B, Eltis LD, Dowling DN, Timmis KN: Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation. Gene. 1993 Aug 16;130(1):47-55. [Article]
  2. Chain PS, Denef VJ, Konstantinidis KT, Vergez LM, Agullo L, Reyes VL, Hauser L, Cordova M, Gomez L, Gonzalez M, Land M, Lao V, Larimer F, LiPuma JJ, Mahenthiralingam E, Malfatti SA, Marx CJ, Parnell JJ, Ramette A, Richardson P, Seeger M, Smith D, Spilker T, Sul WJ, Tsoi TV, Ulrich LE, Zhulin IB, Tiedje JM: Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp genome shaped for versatility. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15280-7. Epub 2006 Oct 9. [Article]
  3. Eltis LD, Hofmann B, Hecht HJ, Lunsdorf H, Timmis KN: Purification and crystallization of 2,3-dihydroxybiphenyl 1,2-dioxygenase. J Biol Chem. 1993 Feb 5;268(4):2727-32. [Article]
  4. Han S, Eltis LD, Timmis KN, Muchmore SW, Bolin JT: Crystal structure of the biphenyl-cleaving extradiol dioxygenase from a PCB-degrading pseudomonad. Science. 1995 Nov 10;270(5238):976-80. [Article]
  5. Vaillancourt FH, Han S, Fortin PD, Bolin JT, Eltis LD: Molecular basis for the stabilization and inhibition of 2, 3-dihydroxybiphenyl 1,2-dioxygenase by t-butanol. J Biol Chem. 1998 Dec 25;273(52):34887-95. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB019252'-Chloro-Biphenyl-2,3-DiolexperimentalunknownDetails
DB022321,2-DihydroxybenzeneexperimentalunknownDetails
DB02923Biphenyl-2,3-DiolexperimentalunknownDetails
DB032592',6'-Dichloro-Biphenyl-2,6-DiolexperimentalunknownDetails
DB034543-methyl-benzene-1,2-diolexperimentalunknownDetails
DB03900tert-butanolexperimentalunknownDetails