4-trimethylaminobutyraldehyde dehydrogenase

Details

Name
4-trimethylaminobutyraldehyde dehydrogenase
Synonyms
  • 1.2.1.47
  • Aldehyde dehydrogenase E3 isozyme
  • Aldehyde dehydrogenase family 9 member A1
  • ALDH4
  • ALDH7
  • ALDH9
  • Gamma-aminobutyraldehyde dehydrogenase
  • R-aminobutyraldehyde dehydrogenase
  • TMABADH
Gene Name
ALDH9A1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0000571|4-trimethylaminobutyraldehyde dehydrogenase
MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA
AFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYY
AGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFK
PSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKI
MEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEI
LDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIY
VPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLA
AGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQL
KTVCVEMGDVESAF
Number of residues
494
Molecular Weight
53801.495
Theoretical pI
5.61
GO Classification
Functions
1-pyrroline dehydrogenase activity / 3-chloroallyl aldehyde dehydrogenase activity / 4-trimethylammoniobutyraldehyde dehydrogenase activity / aldehyde dehydrogenase (NAD) activity / aminobutyraldehyde dehydrogenase activity
Processes
branched-chain amino acid catabolic process / carnitine biosynthetic process / cellular aldehyde metabolic process / cellular nitrogen compound metabolic process / hormone metabolic process / neurotransmitter biosynthetic process / oxidation-reduction process / small molecule metabolic process
Components
cytoplasm / cytosol / extracellular exosome / mitochondrion
General Function
Aminobutyraldehyde dehydrogenase activity
Specific Function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010063|4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)
ATGTTTCTCCGAGCAGGCCTGGCCGCGCTCTCCCCGCTTCTTCGCAGTCTTCGGCCCTCT
CCTGTCGCCGCCATGAGCACTGGCACCTTCGTCGTGTCGCAGCCGCTCAATTACCGCGGC
GGGGCCCGCGTGGAGCCGGCGGACGCCTCCGGTACCGAGAAAGCTTTCGAGCCAGCAACC
GGCCGAGTGATAGCTACTTTCACATGTTCAGGAGAAAAGGAAGTAAATTTGGCTGTTCAA
AATGCAAAGGCTGCTTTTAAAATATGGAGTCAAAAATCTGGCATGGAGCGTTGCCGAATC
CTTTTGGAGGCTGCCAGGATAATAAGGGAACGGGAGGATGAAATTGCTACTATGGAGTGC
ATCAACAATGGCAAGTCCATCTTTGAGGCCCGCTTGGACATTGACATTTCCTGGCAGTGC
CTGGAGTATTATGCGGGCTTGGCTGCATCCATGGCTGGTGAACACATCCAGCTCCCAGGT
GGATCGTTTGGTTATACCAGAAGAGAACCACTTGGGGTATGTGTGGGAATAGGAGCATGG
AACTACCCCTTTCAGATTGCCTCTTGGAAGTCGGCTCCAGCATTAGCCTGTGGTAATGCC
ATGGTCTTTAAACCTTCTCCCTTTACACCTGTTTCTGCATTGCTACTGGCTGAAATCTAC
AGTGAGGCTGGTGTACCTCCTGGGCTCTTCAATGTGGTGCAGGGAGGGGCTGCCACAGGC
CAGTTTCTGTGTCAGCATCCCGATGTGGCCAAAGTCTCCTTCACTGGAAGTGTGCCCACT
GGCATGAAGATCATGGAGATGTCAGCTAAAGGAATCAAACCTGTTACCTTGGAACTTGGA
GGCAAATCTCCACTCATCATCTTCTCAGACTGTGATATGAACAATGCTGTAAAGGGGGCG
CTGATGGCCAACTTCCTCACACAAGGCCAGGTTTGCTGTAATGGCACAAGAGTATTTGTG
CAGAAAGAAATTCTTGATAAATTTACAGAGGAAGTGGTGAAACAGACCCAAAGGATTAAA
ATTGGAGATCCCCTTCTGGAAGATACAAGGATGGGTCCACTCATCAACCGACCACACCTG
GAGCGAGTCCTTGGGTTTGTCAAAGTGGCAAAGGAGCAGGGTGCTAAAGTGTTATGTGGT
GGAGATATATATGTACCTGAAGATCCCAAATTAAAGGATGGATATTACATGAGACCTTGT
GTATTAACTAATTGCAGAGACGACATGACCTGTGTGAAGGAAGAGATCTTTGGGCCTGTT
ATGTCCATTTTATCATTTGACACTGAAGCTGAGGTTCTAGAAAGAGCCAATGATACCACT
TTTGGACTAGCAGCTGGCGTCTTTACCAGGGACATCCAACGGGCTCATAGAGTGGTAGCT
GAGCTTCAGGCTGGGACGTGCTTCATTAACAACTATAACGTCAGCCCAGTGGAGTTGCCC
TTTGGTGGATATAAGAAGTCAGGATTTGGCAGAGAGAACGGCCGTGTGACAATCGAATAT
TATTCACAGCTGAAGACTGTGTGTGTGGAGATGGGTGATGTGGAATCTGCTTTTTGA
Chromosome Location
1
Locus
1q23.1
External Identifiers
ResourceLink
UniProtKB IDP49189
UniProtKB Entry NameAL9A1_HUMAN
GenBank Protein ID1049219
GenBank Gene IDU34252
GenAtlas IDALDH9A1
HGNC IDHGNC:412
General References
  1. Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A: Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression. Genomics. 1996 Jun 15;34(3):376-80. [Article]
  2. Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ: Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. J Biol Chem. 2000 Mar 10;275(10):7390-4. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00157NADHapproved, nutraceuticalunknownDetails