Neuropeptide Y receptor type 4
Details
- Name
- Neuropeptide Y receptor type 4
- Synonyms
- NPY4-R
- Pancreatic polypeptide receptor 1
- PP1
- PPYR1
- Gene Name
- NPY4R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011730|Neuropeptide Y receptor type 4 MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE VSKGSLRLSGRSNPI
- Number of residues
- 375
- Molecular Weight
- 42194.55
- Theoretical pI
- 8.18
- GO Classification
- FunctionsG-protein coupled receptor activity / pancreatic polypeptide receptor activity / peptide binding / peptide YY receptor activityProcessesblood circulation / cell surface receptor signaling pathway / digestion / feeding behavior / G-protein coupled receptor signaling pathway / neuropeptide signaling pathwayComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Peptide yy receptor activity
- Specific Function
- Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 40-60 88-108 117-137 156-176 213-233 264-284 302-322
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011731|Neuropeptide Y receptor type 4 (NPY4R) ATGAACACCTCTCACCTCCTGGCCTTGCTGCTCCCAAAATCTCCACAAGGTGAAAACAGA AGCAAACCCCTGGGCACCCCATACAACTTCTCTGAACATTGCCAGGATTCCGTGGACGTG ATGGTCTTCATTGTCACTTCCTACAGCATTGAGACTGTCGTGGGGGTCCTGGGTAACCTC TGCCTGATGTGTGTAACTGTGAGGCAGAAGGAGAAAGCCAACGTGACCAACCTGCTTATC GCCAACCTGGCCTTCTCTGACTTCCTCATGTGCCTCCTCTGCCAGCCGCTGACCGCCGTC TACACCATCATGGACTACTGGATCTTTGGAGAGACCCTCTGCAAGATGTCGGCCTTCATC CAGTGCATGTCGGTGACGGTCTCCATCCTCTCGCTCGTCCTCGTGGCCCTGGAGAGGCAT CAGCTCATCATCAACCCAACAGGCTGGAAGCCCAGCATCTCACAGGCCTACCTGGGGATT GTGCTCATCTGGGTCATTGCCTGTGTCCTCTCCCTGCCCTTCCTGGCCAACAGCATCCTG GAGAATGTCTTCCACAAGAACCACTCCAAGGCTCTGGAGTTCCTGGCGGATAAGGTGGTC TGTACCGAGTCCTGGCCACTGGCTCACCACCGCACCATCTACACCACCTTCCTGCTCCTC TTCCAGTACTGCCTCCCACTGGGCTTCATCTTGGTCTGTTATGCACGCATCTACCGGCGC CTGCAGAGGCAGGGGCGCGTGTTTCACAAGGGCACCTACAGCTTGCGAGCTGGGCACATG AAGCAGGTCAATGTGGTGCTGGTGGTGATGGTGGTGGCCTTTGCCGTGCTCTGGCTGCCT CTGCATGTGTTCAACAGCCTGGAAGACTGGCACCATGAGGCCATCCCCATCTGCCATGGG AACCTCATCTTCTTAGTGTGCCACTTGCTTGCCATGGCCTCCACCTGTGTCAACCCATTC ATCTATGGCTTTCTCAACACCAACTTCAAGAAGGAGATCAAGGCCCTGGTGCTGACTTGC CAGCAGAGCGCCCCCCTGGAGGAGTCAGAGCATCTGCCCCTGTCCACAGTACATACGGAA GTCTCCAAAGGGTCCCTGAGGCTAAGTGGCAGGTCCAATCCCATTTAA
- Chromosome Location
- 10
- Locus
- 10q11.2
- External Identifiers
Resource Link UniProtKB ID P50391 UniProtKB Entry Name NPY4R_HUMAN GenBank Gene ID U35232 GenAtlas ID PPYR1 HGNC ID HGNC:9329 - General References
- Bard JA, Walker MW, Branchek TA, Weinshank RL: Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J Biol Chem. 1995 Nov 10;270(45):26762-5. [Article]
- Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D: Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J Biol Chem. 1995 Dec 8;270(49):29123-8. [Article]
- Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W: Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4661-5. [Article]
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