Ras-related protein Rab-7a

Details

Name
Ras-related protein Rab-7a
Synonyms
  • RAB7
Gene Name
RAB7A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009406|Ras-related protein Rab-7a
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQ
IWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPF
VVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEV
ELYNEFPEPIKLDKNDRAKASAESCSC
Number of residues
207
Molecular Weight
23489.55
Theoretical pI
Not Available
GO Classification
Functions
GDP binding / GTP binding / GTPase activity
Processes
antigen processing and presentation of exogenous peptide antigen via MHC class II / bone resorption / early endosome to late endosome transport / endocytosis / endosome to lysosome transport / epidermal growth factor catabolic process / lipophagy / phagosome acidification / phagosome maturation / phagosome-lysosome fusion / positive regulation of exosomal secretion / positive regulation of protein catabolic process / positive regulation of viral process / protein targeting to lysosome / protein to membrane docking / protein transport / Rab protein signal transduction / regulation of autophagosome assembly / retrograde transport, endosome to Golgi / viral release from host cell
Components
alveolar lamellar body / autophagosome membrane / extracellular exosome / extrinsic component of lysosome membrane / Golgi apparatus / intracellular membrane-bounded organelle / late endosome / late endosome membrane / lipid particle / lysosomal membrane / lysosome / melanosome membrane / phagocytic vesicle / phagocytic vesicle membrane / pre-autophagosomal structure membrane / terminal bouton / vacuolar membrane
General Function
Gtpase activity
Specific Function
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic vesicle
Gene sequence
>lcl|BSEQ0017451|Ras-related protein Rab-7a (RAB7A)
ATGACCTCTAGGAAGAAAGTGTTGCTGAAGGTTATCATCCTGGGAGATTCTGGAGTCGGG
AAGACATCACTCATGAACCAGTATGTGAATAAGAAATTCAGCAATCAGTACAAAGCCACA
ATAGGAGCTGACTTTCTGACCAAGGAGGTGATGGTGGATGACAGGCTAGTCACAATGCAG
ATATGGGACACAGCAGGACAGGAACGGTTCCAGTCTCTCGGTGTGGCCTTCTACAGAGGT
GCAGACTGCTGCGTTCTGGTATTTGATGTGACTGCCCCCAACACATTCAAAACCCTAGAT
AGCTGGAGAGATGAGTTTCTCATCCAGGCCAGTCCCCGAGATCCTGAAAACTTCCCATTT
GTTGTGTTGGGAAACAAGATTGACCTCGAAAACAGACAAGTGGCCACAAAGCGGGCACAG
GCCTGGTGCTACAGCAAAAACAACATTCCCTACTTTGAGACCAGTGCCAAGGAGGCCATC
AACGTGGAGCAGGCGTTCCAGACGATTGCACGGAATGCACTTAAGCAGGAAACGGAGGTG
GAGCTGTACAACGAATTTCCTGAACCTATCAAACTGGACAAGAATGACCGGGCCAAGGCC
TCGGCAGAAAGCTGCAGTTGCTGA
Chromosome Location
3
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP51149
UniProtKB Entry NameRAB7A_HUMAN
HGNC IDHGNC:9788
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails