Sensor histidine kinase CitA

Details

Name
Sensor histidine kinase CitA
Synonyms
  • 2.7.13.3
Gene Name
citA
Organism
Klebsiella pneumoniae
Amino acid sequence
>lcl|BSEQ0016619|Sensor histidine kinase CitA
MSIYPMYTRKITHWFARRSFQNRIFLLILFTSTIVMLAMSWYLTDITEERLHYQVGQRAL
IQAMQISAMPELVEAVQKRDLARIKALIDPMRSFSDATYITVGDASGQRLYHVNPDEIGK
SMEGGDSDEALINAKSYVSVRKGSLGSSLRGKSPIQDATGKVIGIVSVGYTIEQLENWLS
LQISSLLIPMAIMLLLLLFCARRFSLHIKKQMLNMEPQQLSQLLIQQSVLFESVFEGLIA
IDSDYKITAINQTARRLLNLSQPEPTLIGKRISSVISQEVFFYDAPQTNKKDEIVTFNQI
KVIASRMAVILNNEPQGWVISFRSKDDINTLSLQLSQVQQYADNLRAVQHEHRNLISTIA
GLLFLKRYNQALELIQQQSESHQKVIDFIARNFQDNHLAGLLIGKYYRAKELGLELIFDP
ACFVDRLPTALSHNEWISIVGNLLDNAYNASLRQPQGSKQIECLINSDGQEVIIEIADQG
CGIDEALRDRIFERGVTSSASKDHGIGLWLVRSYVEQAGGSIVVENNIPFGTIFTLYIPL
TRDEHHG
Number of residues
547
Molecular Weight
61779.46
Theoretical pI
6.8
GO Classification
Functions
ATP binding / phosphorelay sensor kinase activity
Components
integral component of membrane / intracellular / plasma membrane
General Function
Phosphorelay sensor kinase activity
Specific Function
Member of the two-component regulatory system CitA/CitB. Probably activates CitB by phosphorylation. The periplasmic domain binds H-citrate(2-), which is essential for induction of the citrate-fermentation genes.
Pfam Domain Function
Transmembrane Regions
24-44 181-201
Cellular Location
Cell inner membrane
Gene sequence
>lcl|BSEQ0003844|1644 bp
ATGTCTATCTACCCAATGTATACCCGAAAAATCACCCACTGGTTTGCCAGGCGATCGTTT
CAGAATCGCATCTTCCTGCTGATCTTATTCACCTCGACGATCGTCATGCTGGCGATGTCA
TGGTATCTGACAGACATTACCGAGGAGCGTCTGCATTATCAGGTCGGGCAACGGGCGCTG
ATTCAGGCGATGCAGATTTCGGCGATGCCGGAGCTGGTGGAGGCAGTGCAGAAACGCGAT
CTCGCCAGAATCAAAGCCCTTATCGACCCCATGCGTTCGTTCTCCGACGCCACCTACATC
ACCGTCGGTGATGCCAGCGGCCAGCGCCTCTATCACGTCAATCCTGATGAAATCGGCAAA
TCGATGGAAGGCGGCGATAGCGATGAGGCGTTGATAAACGCTAAAAGCTACGTGTCAGTG
CGCAAAGGCTCGCTGGGATCGTCGCTGCGCGGTAAATCGCCGATTCAGGACGCAACCGGC
AAGGTGATCGGCATTGTGTCGGTAGGCTATACCATTGAGCAACTGGAAAACTGGCTCAGC
CTGCAGATAAGTTCGCTGCTGATCCCGATGGCCATCATGTTACTGCTTCTGCTCTTTTGC
GCCCGCCGCTTCTCACTGCATATCAAAAAACAGATGCTCAATATGGAACCCCAGCAGCTG
TCACAGCTGTTGATCCAGCAAAGCGTGCTGTTTGAATCGGTGTTCGAAGGGCTTATCGCC
ATCGACTCCGATTATAAAATCACTGCGATTAATCAGACTGCGCGTCGCCTGCTCAATTTG
AGTCAGCCGGAACCGACGCTTATCGGCAAACGGATCAGCAGCGTTATCTCGCAGGAGGTC
TTCTTCTACGATGCGCCACAGACCAATAAAAAAGACGAGATCGTTACCTTCAATCAGATC
AAAGTGATCGCCAGCCGGATGGCGGTGATCTTAAACAATGAGCCACAGGGCTGGGTGATC
AGCTTTCGCAGCAAAGACGATATCAACACCCTTAGCCTGCAGCTTAGCCAGGTACAACAA
TATGCCGATAACCTGCGCGCCGTACAGCATGAGCATCGCAATCTGATCTCCACTATCGCC
GGTCTGCTGTTTCTTAAACGCTATAACCAAGCGCTGGAACTTATCCAACAGCAGTCGGAA
AGTCACCAGAAGGTGATCGATTTTATTGCACGCAATTTCCAGGACAACCACCTGGCCGGG
CTGTTGATCGGCAAATATTACCGGGCCAAAGAGCTTGGACTTGAGCTGATTTTCGATCCG
GCCTGCTTCGTTGATAGATTACCTACCGCCCTTTCGCACAACGAATGGATCTCGATCGTG
GGGAATCTACTTGATAACGCCTACAATGCCAGCCTGCGTCAACCGCAGGGTTCAAAACAG
ATCGAATGCCTGATCAACAGTGATGGCCAGGAGGTGATCATTGAGATCGCCGACCAGGGA
TGCGGCATTGACGAGGCGCTGCGCGATCGGATCTTCGAGCGCGGCGTCACCAGCAGCGCC
AGCAAAGATCATGGTATCGGACTCTGGCTAGTACGCAGCTACGTGGAACAAGCAGGCGGC
AGTATCGTCGTCGAAAATAATATTCCTTTTGGCACCATTTTTACGCTTTATATCCCCCTG
ACCCGAGATGAACATCATGGATAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP52687
UniProtKB Entry NameCITA_KLEPN
GenBank Protein ID924991
GenBank Gene IDU31464
General References
  1. Bott M, Meyer M, Dimroth P: Regulation of anaerobic citrate metabolism in Klebsiella pneumoniae. Mol Microbiol. 1995 Nov;18(3):533-46. [Article]
  2. Kaspar S, Perozzo R, Reinelt S, Meyer M, Pfister K, Scapozza L, Bott M: The periplasmic domain of the histidine autokinase CitA functions as a highly specific citrate receptor. Mol Microbiol. 1999 Aug;33(4):858-72. [Article]
  3. Gerharz T, Reinelt S, Kaspar S, Scapozza L, Bott M: Identification of basic amino acid residues important for citrate binding by the periplasmic receptor domain of the sensor kinase CitA. Biochemistry. 2003 May 20;42(19):5917-24. [Article]
  4. Reinelt S, Hofmann E, Gerharz T, Bott M, Madden DR: The structure of the periplasmic ligand-binding domain of the sensor kinase CitA reveals the first extracellular PAS domain. J Biol Chem. 2003 Oct 3;278(40):39189-96. Epub 2003 Jul 16. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04414HeptamolybdateexperimentalunknownDetails
DB04494Dihydroxy(oxo)molybdenum(6+)experimentalunknownDetails