Metallo-beta-lactamase L1
Details
- Name
- Metallo-beta-lactamase L1
- Synonyms
- 3.5.2.6
- Beta-lactamase type II
- Penicillinase
- Gene Name
- Not Available
- Organism
- Pseudomonas maltophilia
- Amino acid sequence
>lcl|BSEQ0012346|Metallo-beta-lactamase L1 MRSTLLAFALAVALPAAHTSAAEVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLT ALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRR TGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAG HTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCD VLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAGAR
- Number of residues
- 290
- Molecular Weight
- 30800.635
- Theoretical pI
- 6.92
- GO Classification
- Functionsbeta-lactamase activity / zinc ion bindingProcessesantibiotic catabolic process / response to antibioticComponentsperiplasmic space
- General Function
- Zinc ion binding
- Specific Function
- Has a high activity against imipenem.
- Pfam Domain Function
- Lactamase_B (PF00753)
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0006545|873 bp ATGCGTTCTACCCTGCTCGCCTTCGCCCTGGCCGTCGCTCTTCCGGCCGCCCACACCAGC GCCGCCGAAGTACCACTGCCGCAGCTGCGGGCCTACACCGTGGACGCCTCGTGGCTGCAG CCGATGGCACCGCTGCAGATCGCCGACCACACCTGGCAGATCGGCACCGAGGACCTGACC GCGCTGCTTGTGCAGACCCCCGACGGCGCGGTGCTGCTCGACGGCGGCATGCCGCAGATG GCCAGCCACCTGCTGGACAACATGAAGGCGCGTGGCGTGACGCCTCGGGATCTGCGGCTG ATCCTGCTCAGCCACGCACACGCCGACCATGCCGGACCGGTGGCGGAGCTGAAGCGCCGT ACGGGCGCCAAAGTGGCGGCCAACGCCGAATCGGCGGTGCTGCTGGCGCGTGGCGGCAGC GATGACCTGCACTTCGGCGATGGCATCACCTACCCGCCTGCCAATGCAGACCGCATCGTC ATGGATGGTGAAGTGATCACGGTGGGCGGCATCGTGTTCACCGCGCACTTCATGGCGGGG CACACCCCGGGCAGCACCGCGTGGACCTGGACCGATACCCGCAATGGCAAGCCGGTGCGC ATCGCCTACGCCGACAGCCTGAGTGCACCGGGCTACCAGCTGCAGGGAAACCCCCGTTAT CCGCACCTGATCGAGGATTACAGGCGCAGCTTCGCGACGGTGCGGGCGCTGCCTTGCGAC GTGTTGCTGACACCGCATCCGGGTGCCAGCAACTGGGACTACGCCGCGGGTGCCAGGGCC GGTGCCAAGGCACTGACCTGCAAGGCCTACGCGGATGCGGCAGAACAGAAATTCGACGGG CAGCTGGCCAAGGAAACGGCCGGGGCCCGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P52700 UniProtKB Entry Name BLA1_STEMA GenBank Gene ID X75074 - General References
- Walsh TR, Hall L, Assinder SJ, Nichols WW, Cartwright SJ, MacGowan AP, Bennett PM: Sequence analysis of the L1 metallo-beta-lactamase from Xanthomonas maltophilia. Biochim Biophys Acta. 1994 Jun 21;1218(2):199-201. [Article]
- Bicknell R, Emanuel EL, Gagnon J, Waley SG: The production and molecular properties of the zinc beta-lactamase of Pseudomonas maltophilia IID 1275. Biochem J. 1985 Aug 1;229(3):791-7. [Article]
- Ullah JH, Walsh TR, Taylor IA, Emery DC, Verma CS, Gamblin SJ, Spencer J: The crystal structure of the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia at 1.7 A resolution. J Mol Biol. 1998 Nov 20;284(1):125-36. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB04740 Moxalactam (hydrolyzed) experimental unknown Details DB07939 N-(3-MERCAPTOPROPANOYL)-D-ALANINE experimental unknown Details DB08069 4-AMINO-5-(2-METHYLPHENYL)-2,4-DIHYDRO-3H-1,2,4-TRIAZOLE-3-THIONE experimental unknown Details DB02032 Epicaptopril experimental unknown Details DB08199 N-[(BENZYLOXY)CARBONYL]-L-CYSTEINYLGLYCINE experimental unknown Details DB02365 1,10-Phenanthroline experimental unknown Details DB08702 2,5-DIPHENYLFURAN-3,4-DICARBOXYLIC ACID experimental unknown Details