Ubiquitin carboxyl-terminal hydrolase 14

Details

Name
Ubiquitin carboxyl-terminal hydrolase 14
Synonyms
  • 3.4.19.12
  • Deubiquitinating enzyme 14
  • TGT
  • Ubiquitin thioesterase 14
  • Ubiquitin-specific-processing protease 14
Gene Name
USP14
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049793|Ubiquitin carboxyl-terminal hydrolase 14
MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGN
IKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATV
QCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLH
MAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKK
SLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITK
QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCT
PELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDL
QAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLY
GPRRVEIMEEESEQ
Number of residues
494
Molecular Weight
56068.665
Theoretical pI
Not Available
GO Classification
Functions
cysteine-type endopeptidase activity / endopeptidase inhibitor activity / proteasome binding / thiol-dependent ubiquitin-specific protease activity / tRNA guanylyltransferase activity
Processes
chemical synaptic transmission / negative regulation of ER-associated ubiquitin-dependent protein catabolic process / protein deubiquitination / regulation of chemotaxis / regulation of proteasomal protein catabolic process / ubiquitin-dependent protein catabolic process
Components
cell surface / cytoplasmic vesicle / cytosol / extracellular exosome / plasma membrane / proteasome complex / synapse
General Function
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Specific Function
Cysteine-type endopeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0049794|Ubiquitin carboxyl-terminal hydrolase 14 (USP14)
ATGCCGCTCTACTCCGTTACTGTAAAATGGGGAAAGGAGAAATTTGAAGGTGTAGAATTG
AATACAGATGAACCTCCAATGGTATTCAAGGCTCAGCTGTTTGCGTTGACTGGAGTCCAG
CCTGCCAGACAGAAAGTTATGGTGAAAGGAGGAACGCTAAAGGATGATGATTGGGGAAAC
ATCAAAATAAAAAATGGAATGACTCTACTAATGATGGGGTCAGCAGATGCTCTTCCAGAA
GAACCCTCAGCCAAAACTGTCTTCGTAGAAGACATGACAGAAGAACAGTTAGCATCTGCT
ATGGAGTTACCATGTGGATTGACAAACCTTGGTAACACTTGTTACATGAATGCCACAGTT
CAGTGTATTCGTTCTGTGCCTGAACTCAAAGATGCCCTTAAAAGGTATGCAGGTGCCTTG
AGAGCTTCAGGGGAAATGGCTTCAGCGCAGTATATTACTGCAGCCCTTAGAGATTTGTTT
GATTCCATGGATAAAACTTCTTCCAGTATTCCACCTATTATTCTACTGCAGTTTTTGCAC
ATGGCTTTCCCACAGTTTGCCGAGAAAGGTGAACAAGGACAGTATCTTCAACAGGATGCT
AATGAATGTTGGATACAAATGATGCGAGTATTGCAACAGAAATTGGAAGCAATAGAGGAT
GATTCTGTTAAAGAGACAGACTCCTCATCTGCATCGGCAGCGACACCTTCTAAAAAGAAA
AGTTTAATCGATCAGTTCTTCGGTGTTGAGTTTGAAACTACCATGAAATGTACAGAATCT
GAAGAAGAAGAAGTCACCAAAGGAAAGGAAAATCAACTTCAGCTTAGCTGTTTTATCAAT
CAGGAAGTCAAGTATCTTTTTACAGGACTTAAATTGCGACTTCAGGAAGAAATCACCAAA
CAGTCTCCAACGTTGCAAAGAAATGCCTTGTATATCAAATCTTCCAAGATCAGCCGGCTG
CCTGCTTACTTGACCATTCAGATGGTTCGATTTTTTTATAAAGAGAAGGAATCTGTGAAT
GCCAAAGTTCTTAAGGATGTTAAATTTCCTCTTATGTTGGATATGTATGAACTGTGTACA
CCAGAACTTCAAGAGAAAATGGTGTCTTTTCGATCCAAATTCAAGGATCTAGAAGATAAA
AAAGTGAATCAGCAGCCAAATACAAGTGACAAAAAGAGTAGTCCCCAGAAAGAAGTTAAG
TATGAACCCTTTTCTTTTGCTGATGATATTGGCTCCAATAATTGTGGATACTATGACTTA
CAAGCAGTACTAACACACCAGGGAAGGTCTAGTTCTTCAGGTCATTATGTATCATGGGTG
AAAAGGAAACAAGATGAATGGATTAAGTTTGATGATGACAAAGTCAGCATCGTAACACCA
GAAGATATCTTACGGCTTTCTGGTGGTGGAGACTGGCATATCGCTTACGTTCTACTCTAT
GGGCCTCGCAGAGTTGAAATAATGGAAGAGGAAAGTGAACAGTAA
Chromosome Location
18
Locus
18p11.32
External Identifiers
ResourceLink
UniProtKB IDP54578
UniProtKB Entry NameUBP14_HUMAN
HGNC IDHGNC:12612
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails