Ephrin type-B receptor 1

Details

Name
Ephrin type-B receptor 1
Synonyms
  • 2.7.10.1
  • EK6
  • ELK
  • EPH tyrosine kinase 2
  • EPH-like kinase 6
  • EPHT2
  • HEK6
  • NET
  • Neuronally-expressed EPH-related tyrosine kinase
  • Tyrosine-protein kinase receptor EPH-2
Gene Name
EPHB1
UniProtKB Entry
P54762Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0051760|Ephrin type-B receptor 1
MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQV
CNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSV
IATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDY
GACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYC
NGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPI
CTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIIC
KKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPP
QHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFN
SSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLP
LIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTY
EDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK
QRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQ
LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS
SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD
YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQ
PLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAG
HQKKILNSIHSMRVQISQSPTAMA
Number of residues
984
Molecular Weight
109884.175
Theoretical pI
Not Available
GO Classification
Functions
protein-containing complex binding
Processes
hindbrain tangential cell migration / modulation of chemical synaptic transmission
Components
glutamatergic synapse
General Function
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity)
Specific Function
Atp binding
Pfam Domain Function
Signal Regions
1-17
Transmembrane Regions
541-563
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0051761|Ephrin type-B receptor 1 (EPHB1)
ATGGCCCTGGATTATCTACTACTGCTCCTCCTGGCATCCGCAGTGGCTGCGATGGAAGAA
ACGTTAATGGACACCAGAACGGCTACTGCAGAGCTGGGCTGGACGGCCAATCCTGCGTCC
GGGTGGGAAGAAGTCAGTGGCTACGATGAAAACCTGAACACCATCCGCACCTACCAGGTG
TGCAATGTCTTCGAGCCCAACCAGAACAATTGGCTGCTCACCACCTTCATCAACCGGCGG
GGGGCCCATCGCATCTACACAGAGATGCGCTTCACTGTGAGAGACTGCAGCAGCCTCCCT
AATGTCCCAGGATCCTGCAAGGAGACCTTCAACTTGTATTACTATGAGACTGACTCTGTC
ATTGCCACCAAGAAGTCAGCCTTCTGGTCTGAGGCCCCCTACCTCAAAGTAGACACCATT
GCTGCAGATGAGAGCTTCTCCCAGGTGGACTTTGGGGGAAGGCTGATGAAGGTAAACACA
GAAGTCAGGAGCTTTGGGCCTCTTACTCGGAATGGTTTTTACCTCGCTTTTCAGGATTAT
GGAGCCTGTATGTCTCTTCTTTCTGTCCGTGTCTTCTTCAAAAAGTGTCCCAGCATTGTG
CAAAATTTTGCAGTGTTTCCAGAGACTATGACAGGGGCAGAGAGCACATCTCTGGTGATT
GCTCGGGGCACATGCATCCCCAACGCAGAGGAAGTGGACGTGCCCATCAAACTCTACTGC
AACGGGGATGGGGAATGGATGGTGCCTATTGGGCGATGCACCTGCAAGCCTGGCTATGAG
CCTGAGAACAGCGTGGCATGCAAGGCTTGCCCTGCAGGGACATTCAAGGCCAGCCAGGAA
GCTGAAGGCTGCTCCCACTGCCCCTCCAACAGCCGCTCCCCTGCAGAGGCGTCTCCCATC
TGCACCTGTCGGACCGGTTATTACCGAGCGGACTTTGACCCTCCAGAAGTGGCATGCACT
AGCGTCCCATCAGGTCCCCGCAATGTTATCTCCATCGTCAATGAGACGTCCATCATTCTG
GAGTGGCACCCTCCAAGGGAGACAGGTGGGCGGGATGATGTGACCTACAACATCATCTGC
AAAAAGTGCCGGGCAGACCGCCGGAGCTGCTCCCGCTGTGACGACAATGTGGAGTTTGTG
CCCAGGCAGCTGGGCCTGACGGAGTGCCGCGTCTCCATCAGCAGCCTGTGGGCCCACACC
CCCTACACCTTTGACATCCAGGCCATCAATGGAGTCTCCAGCAAGAGTCCCTTCCCCCCA
CAGCACGTCTCTGTCAACATCACCACAAACCAAGCCGCCCCCTCCACCGTTCCCATCATG
CACCAAGTCAGTGCCACTATGAGGAGCATCACCTTGTCATGGCCACAGCCGGAGCAGCCC
AATGGCATCATCCTGGACTATGAGATCCGGTACTATGAGAAGGAACACAATGAGTTCAAC
TCCTCCATGGCCAGGAGTCAGACCAACACAGCAAGGATTGATGGGCTGCGGCCTGGCATG
GTATATGTGGTACAGGTGCGTGCCCGCACTGTTGCTGGCTACGGCAAGTTCAGTGGCAAG
ATGTGCTTCCAGACTCTGACTGACGATGATTACAAGTCAGAGCTGAGGGAGCAGCTGCCC
CTGATTGCTGGCTCGGCAGCGGCCGGGGTCGTGTTCGTTGTGTCCTTGGTGGCCATCTCT
ATCGTCTGTAGCAGGAAACGGGCTTATAGCAAAGAGGCTGTGTACAGCGATAAGCTCCAG
CATTACAGCACAGGCCGAGGCTCCCCAGGGATGAAGATCTACATTGACCCCTTCACTTAC
GAGGATCCCAACGAAGCTGTCCGGGAGTTTGCCAAGGAGATTGATGTATCTTTTGTGAAA
ATTGAAGAGGTCATCGGAGCAGGGGAGTTTGGAGAAGTGTACAAGGGGCGTTTGAAACTG
CCAGGCAAGAGGGAAATCTACGTGGCCATCAAGACCCTGAAGGCAGGGTACTCGGAGAAG
CAGCGTCGGGACTTTCTGAGTGAGGCGAGCATCATGGGCCAGTTCGACCATCCTAACATC
ATTCGCCTGGAGGGTGTGGTCACCAAGAGTCGGCCTGTCATGATCATCACAGAGTTCATG
GAGAATGGTGCATTGGATTCTTTCCTCAGGCAAAATGACGGGCAGTTCACCGTGATCCAG
CTTGTGGGTATGCTCAGGGGCATCGCTGCTGGCATGAAGTACCTGGCTGAGATGAATTAT
GTGCATCGGGACCTGGCTGCTAGGAACATTCTGGTCAACAGTAACCTGGTGTGCAAGGTG
TCCGACTTTGGCCTCTCCCGCTACCTCCAGGATGACACCTCAGATCCCACCTACACCAGC
TCCTTGGGAGGGAAGATCCCTGTGAGATGGACAGCTCCAGAGGCCATCGCCTACCGCAAG
TTCACTTCAGCCAGCGACGTTTGGAGCTATGGGATCGTCATGTGGGAAGTCATGTCATTT
GGAGAGAGACCCTATTGGGATATGTCCAACCAAGATGTCATCAATGCCATCGAGCAGGAC
TACCGGCTGCCCCCACCCATGGACTGTCCAGCTGCTCTACACCAGCTCATGCTGGACTGT
TGGCAGAAGGACCGGAACAGCCGGCCCCGGTTTGCGGAGATTGTCAACACCCTAGATAAG
ATGATCCGGAACCCGGCAAGTCTCAAGACTGTGGCAACCATCACCGCCGTGCCTTCCCAG
CCCCTGCTCGACCGCTCCATCCCAGACTTCACGGCCTTTACCACCGTGGATGACTGGCTC
AGCGCCATCAAAATGGTCCAGTACAGGGACAGCTTCCTCACTGCTGGCTTCACCTCCCTC
CAGCTGGTCACCCAGATGACATCAGAAGACCTCCTGAGAATAGGCATCACCTTGGCAGGC
CATCAGAAGAAGATCCTGAACAGCATTCATTCTATGAGGGTCCAGATAAGTCAGTCACCA
ACGGCAATGGCATGA
Chromosome Location
3
Locus
3q22.2
External Identifiers
ResourceLink
UniProtKB IDP54762
UniProtKB Entry NameEPHB1_HUMAN
GeneCard IDEPHB1
HGNC IDHGNC:3392
PDB ID(s)2DJS, 2EAO, 3ZFX, 5MJA, 5MJB, 6UMW, 7KPL, 7KPM
KEGG IDhsa:2047
IUPHAR/Guide To Pharmacology ID1830
NCBI Gene ID2047
General References
  1. Tang XX, Biegel JA, Nycum LM, Yoshioka A, Brodeur GM, Pleasure DE, Ikegaki N: cDNA cloning, molecular characterization, and chromosomal localization of NET(EPHT2), a human EPH-related receptor protein-tyrosine kinase gene preferentially expressed in brain. Genomics. 1995 Sep 20;29(2):426-37. [Article]
  2. Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO: Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J Biol Chem. 1998 Jan 16;273(3):1303-8. [Article]
  3. Jin P, Zhang J, Sumariwalla PF, Ni I, Jorgensen B, Crawford D, Phillips S, Feldmann M, Shepard HM, Paleolog EM: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. Arthritis Res Ther. 2008;10(4):R73. doi: 10.1186/ar2447. Epub 2008 Jul 1. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. 2004 Oct;13(10):2819-24. Epub 2004 Aug 31. [Article]
  8. Stein E, Cerretti DP, Daniel TO: Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. J Biol Chem. 1996 Sep 20;271(38):23588-93. [Article]
  9. Authors unspecified: Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell. 1997 Aug 8;90(3):403-4. [Article]
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  11. Freywald A, Sharfe N, Roifman CM: The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J Biol Chem. 2002 Feb 8;277(6):3823-8. Epub 2001 Nov 16. [Article]
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  14. Fasen K, Cerretti DP, Huynh-Do U: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway. Traffic. 2008 Feb;9(2):251-66. Epub 2007 Dec 19. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Ephrin type-B receptor 1 (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Fostamatinibapproved, investigationalunknowntargetinhibitorDetails
Chlortetracyclineapproved, investigational, vet_approvedunknowntargetinhibitorDetails