Puromycin-sensitive aminopeptidase
Details
- Name
- Puromycin-sensitive aminopeptidase
- Synonyms
- 3.4.11.14
- AAP-S
- Cytosol alanyl aminopeptidase
- PSA
- Gene Name
- NPEPPS
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006671|Puromycin-sensitive aminopeptidase MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSP INYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGF NYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFE ATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPV MSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQW MVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLG ILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKA TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIE RVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN RYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR DAESIHQYLLQRKASPPTV
- Number of residues
- 919
- Molecular Weight
- 103275.36
- Theoretical pI
- 5.44
- GO Classification
- Functionsaminopeptidase activity / metalloaminopeptidase activity / peptide binding / zinc ion bindingProcessesantigen processing and presentation of peptide antigen via MHC class I / cellular response to hypoxia / peptide catabolic process / positive regulation of protein targeting to mitochondrion / protein polyubiquitination / proteolysisComponentscytosol / extracellular exosome / nucleus
- General Function
- Zinc ion binding
- Specific Function
- Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012394|Puromycin-sensitive aminopeptidase (NPEPPS) ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCG CCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTG GGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTG GAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATT GATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTT AACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGT ACGGGAACCTTAAAGATAGATTTTGTTGGAGAGCTGAATGACAAAATGAAAGGTTTCTAT AGAAGTAAATATACTACCCCTTCTGGAGAGGTGCGCTATGCTGCTGTAACACAGTTTGAG GCTACTGATGCCCGAAGGGCTTTTCCTTGCTGGGATGAGCCTGCTATCAAAGCAACTTTT GATATCTCATTGGTTGTTCCTAAAGACAGAGTAGCTTTATCAAACATGAATGTAATTGAC CGGAAACCATACCCTGATGATGAAAATTTAGTGGAAGTGAAGTTTGCCCGCACACCTGTT ATGTCTACATATCTGGTGGCATTTGTTGTGGGTGAATATGACTTTGTAGAAACAAGGTCA AAAGATGGTGTGTGTGTCCGTGTTTACACTCCTGTTGGCAAAGCAGAGCAAGGAAAATTT GCGTTAGAGGTTGCTGCTAAAACCTTGCCTTTTTATAAGGACTACTTCAATGTTCCTTAT CCTCTACCTAAAATTGATCTCATTGCTATTGCAGACTTTGCAGCTGGTGCCATGGAGAAC TGGGGCCTTGTTACTTATAGGGAGACTGCATTGCTTATTGATCCAAAAAATTCCTGTTCT TCATCCCGCCAGTGGGTTGCTCTGGTTGTGGGACATGAACTCGCCCATCAATGGTTTGGA AATCTTGTTACTATGGAATGGTGGACTCATCTTTGGTTAAATGAAGGTTTTGCATCCTGG ATTGAATATCTGTGTGTAGACCACTGCTTCCCAGAGTATGATATTTGGACTCAGTTTGTT TCTGCTGATTACACCCGTGCCCAGGAGCTTGACGCCTTAGATAACAGCCATCCTATTGAA GTCAGTGTGGGCCATCCATCTGAGGTTGATGAGATATTTGATGCTATATCATATAGCAAA GGTGCATCTGTCATCCGAATGCTGCATGACTACATTGGGGATAAGGACTTTAAGAAAGGA ATGAACATGTATTTAACCAAGTTCCAACAAAAGAATGCTGCCACAGAGGATCTCTGGGAA AGTTTAGAAAATGCTAGTGGTAAACCTATAGCAGCTGTGATGAATACCTGGACCAAACAA ATGGGATTTCCCCTCATTTATGTGGAAGCTGAACAGGTAGAAGATGACAGATTATTGAGG TTGTCCCAAAAGAAGTTCTGTGCTGGTGGGTCATATGTTGGTGAAGATTGTCCCCAGTGG ATGGTCCCTATCACAATCTCTACTAGTGAAGACCCCAACCAGGCCAAACTAAAAATTCTA ATGGACAAGCCAGAGATGAATGTGGTTTTGAAAAATGTCAAACCAGACCAATGGGTGAAG TTAAACTTAGGAACAGTTGGGTTTTATCGGACCCAGTACAGCTCTGCCATGCTGGAAAGT TTATTACCAGGCATTCGTGACCTTTCTCTGCCCCCTGTGGATCGACTTGGATTACAGAAT GACCTCTTCTCCTTGGCTCGAGCTGGAATCATTAGCACTGTAGAGGTTCTAAAAGTCATG GAGGCTTTTGTGAATGAGCCCAATTATACTGTATGGAGCGACCTGAGCTGTAACCTGGGG ATTCTCTCAACTCTCTTGTCCCACACAGACTTCTATGAGGAAATCCAGGAGTTTGTGAAA GATGTCTTTTCACCTATAGGGGAGAGACTGGGCTGGGACCCCAAACCTGGAGAAGGTCAT CTCGATGCACTCCTGAGGGGCTTGGTTCTGGGAAAACTAGGAAAAGCAGGACATAAGGCA ACGTTAGAAGAAGCCCGTCGTCGGTTTAAGGACCACGTGGAAGGAAAACAGATTCTCTCC GCTGATCTGAGGAGTCCTGTCTATCTGACTGTTTTGAAGCATGGTGATGGCACTACTTTA GATATTATGTTAAAACTTCATAAACAAGCAGATATGCAAGAAGAGAAAAACCGAATCGAA AGAGTCCTTGGCGCTACTCTTTTGCCTGACCTGATTCAAAAAGTCCTCACGTTTGCACTT TCAGAAGAGGTACGTCCACAGGACACTGTATCGGTAATTGGTGGAGTAGCTGGAGGCAGC AAGCATGGTAGGAAAGCTGCTTGGAAATTCATAAAGGACAACTGGGAAGAACTTTATAAC CGATACCAGGGAGGATTCTTAATATCCAGACTAATAAAGCTATCAGTTGAGGGATTTGCA GTTGATAAAATGGCTGGAGAGGTTAAGGCTTTCTTCGAGAGTCACCCAGCTCCTTCAGCT GAGCGTACCATCCAGCAGTGTTGTGAAAATATTCTGCTGAATGCTGCCTGGCTAAAGCGA GATGCTGAGAGCATCCACCAGTACCTCCTTCAGCGGAAGGCCTCACCACCCACAGTGTGA
- Chromosome Location
- 17
- Locus
- 17q21
- External Identifiers
Resource Link UniProtKB ID P55786 UniProtKB Entry Name PSA_HUMAN GenBank Gene ID AF252387 GenAtlas ID NPEPPS HGNC ID HGNC:7900 - General References
- Tobler AR, Constam DB, Schmitt-Graff A, Malipiero U, Schlapbach R, Fontana A: Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. J Neurochem. 1997 Mar;68(3):889-97. [Article]
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- Thompson MW, Tobler A, Fontana A, Hersh LB: Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. Biochem Biophys Res Commun. 1999 May 10;258(2):234-40. [Article]
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