Puromycin-sensitive aminopeptidase

Details

Name
Puromycin-sensitive aminopeptidase
Synonyms
  • 3.4.11.14
  • AAP-S
  • Cytosol alanyl aminopeptidase
  • PSA
Gene Name
NPEPPS
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006671|Puromycin-sensitive aminopeptidase
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSP
INYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGF
NYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFE
ATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPV
MSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY
PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFG
NLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIE
VSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWE
SLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQW
MVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES
LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLG
ILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKA
TLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIE
RVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYN
RYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR
DAESIHQYLLQRKASPPTV
Number of residues
919
Molecular Weight
103275.36
Theoretical pI
5.44
GO Classification
Functions
aminopeptidase activity / metalloaminopeptidase activity / peptide binding / zinc ion binding
Processes
antigen processing and presentation of peptide antigen via MHC class I / cellular response to hypoxia / peptide catabolic process / positive regulation of protein targeting to mitochondrion / protein polyubiquitination / proteolysis
Components
cytosol / extracellular exosome / nucleus
General Function
Zinc ion binding
Specific Function
Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012394|Puromycin-sensitive aminopeptidase (NPEPPS)
ATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCG
CCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTG
GGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCC
ATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTG
GAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATT
GATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGAAATACATGCTACAGGATTT
AACTATCAGAATGAAGATGAAAAAGTCACCTTGTCTTTCCCTAGTACTCTGCAAACAGGT
ACGGGAACCTTAAAGATAGATTTTGTTGGAGAGCTGAATGACAAAATGAAAGGTTTCTAT
AGAAGTAAATATACTACCCCTTCTGGAGAGGTGCGCTATGCTGCTGTAACACAGTTTGAG
GCTACTGATGCCCGAAGGGCTTTTCCTTGCTGGGATGAGCCTGCTATCAAAGCAACTTTT
GATATCTCATTGGTTGTTCCTAAAGACAGAGTAGCTTTATCAAACATGAATGTAATTGAC
CGGAAACCATACCCTGATGATGAAAATTTAGTGGAAGTGAAGTTTGCCCGCACACCTGTT
ATGTCTACATATCTGGTGGCATTTGTTGTGGGTGAATATGACTTTGTAGAAACAAGGTCA
AAAGATGGTGTGTGTGTCCGTGTTTACACTCCTGTTGGCAAAGCAGAGCAAGGAAAATTT
GCGTTAGAGGTTGCTGCTAAAACCTTGCCTTTTTATAAGGACTACTTCAATGTTCCTTAT
CCTCTACCTAAAATTGATCTCATTGCTATTGCAGACTTTGCAGCTGGTGCCATGGAGAAC
TGGGGCCTTGTTACTTATAGGGAGACTGCATTGCTTATTGATCCAAAAAATTCCTGTTCT
TCATCCCGCCAGTGGGTTGCTCTGGTTGTGGGACATGAACTCGCCCATCAATGGTTTGGA
AATCTTGTTACTATGGAATGGTGGACTCATCTTTGGTTAAATGAAGGTTTTGCATCCTGG
ATTGAATATCTGTGTGTAGACCACTGCTTCCCAGAGTATGATATTTGGACTCAGTTTGTT
TCTGCTGATTACACCCGTGCCCAGGAGCTTGACGCCTTAGATAACAGCCATCCTATTGAA
GTCAGTGTGGGCCATCCATCTGAGGTTGATGAGATATTTGATGCTATATCATATAGCAAA
GGTGCATCTGTCATCCGAATGCTGCATGACTACATTGGGGATAAGGACTTTAAGAAAGGA
ATGAACATGTATTTAACCAAGTTCCAACAAAAGAATGCTGCCACAGAGGATCTCTGGGAA
AGTTTAGAAAATGCTAGTGGTAAACCTATAGCAGCTGTGATGAATACCTGGACCAAACAA
ATGGGATTTCCCCTCATTTATGTGGAAGCTGAACAGGTAGAAGATGACAGATTATTGAGG
TTGTCCCAAAAGAAGTTCTGTGCTGGTGGGTCATATGTTGGTGAAGATTGTCCCCAGTGG
ATGGTCCCTATCACAATCTCTACTAGTGAAGACCCCAACCAGGCCAAACTAAAAATTCTA
ATGGACAAGCCAGAGATGAATGTGGTTTTGAAAAATGTCAAACCAGACCAATGGGTGAAG
TTAAACTTAGGAACAGTTGGGTTTTATCGGACCCAGTACAGCTCTGCCATGCTGGAAAGT
TTATTACCAGGCATTCGTGACCTTTCTCTGCCCCCTGTGGATCGACTTGGATTACAGAAT
GACCTCTTCTCCTTGGCTCGAGCTGGAATCATTAGCACTGTAGAGGTTCTAAAAGTCATG
GAGGCTTTTGTGAATGAGCCCAATTATACTGTATGGAGCGACCTGAGCTGTAACCTGGGG
ATTCTCTCAACTCTCTTGTCCCACACAGACTTCTATGAGGAAATCCAGGAGTTTGTGAAA
GATGTCTTTTCACCTATAGGGGAGAGACTGGGCTGGGACCCCAAACCTGGAGAAGGTCAT
CTCGATGCACTCCTGAGGGGCTTGGTTCTGGGAAAACTAGGAAAAGCAGGACATAAGGCA
ACGTTAGAAGAAGCCCGTCGTCGGTTTAAGGACCACGTGGAAGGAAAACAGATTCTCTCC
GCTGATCTGAGGAGTCCTGTCTATCTGACTGTTTTGAAGCATGGTGATGGCACTACTTTA
GATATTATGTTAAAACTTCATAAACAAGCAGATATGCAAGAAGAGAAAAACCGAATCGAA
AGAGTCCTTGGCGCTACTCTTTTGCCTGACCTGATTCAAAAAGTCCTCACGTTTGCACTT
TCAGAAGAGGTACGTCCACAGGACACTGTATCGGTAATTGGTGGAGTAGCTGGAGGCAGC
AAGCATGGTAGGAAAGCTGCTTGGAAATTCATAAAGGACAACTGGGAAGAACTTTATAAC
CGATACCAGGGAGGATTCTTAATATCCAGACTAATAAAGCTATCAGTTGAGGGATTTGCA
GTTGATAAAATGGCTGGAGAGGTTAAGGCTTTCTTCGAGAGTCACCCAGCTCCTTCAGCT
GAGCGTACCATCCAGCAGTGTTGTGAAAATATTCTGCTGAATGCTGCCTGGCTAAAGCGA
GATGCTGAGAGCATCCACCAGTACCTCCTTCAGCGGAAGGCCTCACCACCCACAGTGTGA
Chromosome Location
17
Locus
17q21
External Identifiers
ResourceLink
UniProtKB IDP55786
UniProtKB Entry NamePSA_HUMAN
GenBank Gene IDAF252387
GenAtlas IDNPEPPS
HGNC IDHGNC:7900
General References
  1. Tobler AR, Constam DB, Schmitt-Graff A, Malipiero U, Schlapbach R, Fontana A: Cloning of the human puromycin-sensitive aminopeptidase and evidence for expression in neurons. J Neurochem. 1997 Mar;68(3):889-97. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Bauer WO, Nanda I, Beck G, Schmid M, Jakob F: Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21. Cytogenet Cell Genet. 2001;92(3-4):221-4. [Article]
  6. Thompson MW, Tobler A, Fontana A, Hersh LB: Cloning and analysis of the gene for the human puromycin-sensitive aminopeptidase. Biochem Biophys Res Commun. 1999 May 10;258(2):234-40. [Article]
  7. Yamamoto Y, Li YH, Ushiyama I, Nishimura A, Ohkubo I, Nishi K: Puromycin-sensitive alanyl aminopeptidase from human liver cytosol: purification and characterization. Forensic Sci Int. 2000 Sep 11;113(1-3):143-6. [Article]
  8. Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H: Two new proteases in the MHC class I processing pathway. Nat Immunol. 2000 Nov;1(5):413-8. [Article]
  9. Thompson MW, Govindaswami M, Hersh LB: Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. Arch Biochem Biophys. 2003 May 15;413(2):236-42. [Article]
  10. Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI: Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006 Dec 19;45(50):15111-9. [Article]
  11. Bhutani N, Venkatraman P, Goldberg AL: Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation. EMBO J. 2007 Mar 7;26(5):1385-96. Epub 2007 Feb 22. [Article]
  12. Kim E, Kwak H, Ahn K: Cytosolic aminopeptidases influence MHC class I-mediated antigen presentation in an allele-dependent manner. J Immunol. 2009 Dec 1;183(11):7379-87. doi: 10.4049/jimmunol.0901489. Epub 2009 Nov 16. [Article]
  13. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  14. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11781TosedostatinvestigationalunknownDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails