2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Details

Name
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
Synonyms
  • 2.3.1.117
  • Tetrahydrodipicolinate N-succinyltransferase
  • Tetrahydropicolinate succinylase
  • THDP succinyltransferase
  • THP succinyltransferase
Gene Name
dapD
Organism
Unknown prokaryotic organism
Amino acid sequence
>lcl|BSEQ0016376|2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
MQQLQNVIESAFERRADITPANVDTVTREAVNQVIGLLDSGALRVAEKIDGQWVTHQWLK
KAVLLSFRINDNKVMDGAETRYYDKVPMKFADYDEARFQKEGFRVVPPATVRQGAFIARN
TVLMPSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIED
NCFIGARSEVVEGVIVEEGSVISMGVYLGQSTRIYDRETGEIHYGRVPAGSVVVSGNLPS
KDGSYSLYCAVIVKKVDAKTRGKVGINELLRTID
Number of residues
274
Molecular Weight
29886.885
Theoretical pI
5.43
GO Classification
Functions
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity
Processes
diaminopimelate biosynthetic process / lysine biosynthetic process via diaminopimelate
Components
cytoplasm
General Function
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate n-succinyltransferase activity
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP56220
UniProtKB Entry NameDAPD_UNKP
General References
  1. Binder DA, Blanchard JS, Roderick SL: Crystallization and preliminary crystallographic analysis of tetrahydrodipicolinate-N-succinyltransferase. Proteins. 1996 Sep;26(1):115-7. [Article]
  2. Schuldt L, Weyand S, Kefala G, Weiss MS: The three-dimensional Structure of a mycobacterial DapD provides insights into DapD diversity and reveals unexpected particulars about the enzymatic mechanism. J Mol Biol. 2009 Jun 26;389(5):863-79. doi: 10.1016/j.jmb.2009.04.046. Epub 2009 Apr 24. [Article]
  3. Beaman TW, Binder DA, Blanchard JS, Roderick SL: Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase. Biochemistry. 1997 Jan 21;36(3):489-94. [Article]
  4. Beaman TW, Blanchard JS, Roderick SL: The conformational change and active site structure of tetrahydrodipicolinate N-succinyltransferase. Biochemistry. 1998 Jul 21;37(29):10363-9. [Article]
  5. Beaman TW, Vogel KW, Drueckhammer DG, Blanchard JS, Roderick SL: Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase. Protein Sci. 2002 Apr;11(4):974-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01856Pimelic AcidexperimentalunknownDetails
DB01992Coenzyme Ainvestigational, nutraceuticalunknownDetails
DB03134L-2-aminopimelic acidexperimentalunknownDetails
DB03699Succinyl-Coenzyme AexperimentalunknownDetails
DB03905Succinamide-CoAexperimentalunknownDetails