Eukaryotic translation initiation factor 6

Details

Name
Eukaryotic translation initiation factor 6
Synonyms
  • B(2)GCN homolog
  • B4 integrin interactor
  • CAB
  • eIF-6
  • EIF3A
  • ITGB4BP
  • p27(BBP)
Gene Name
EIF6
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049659|Eukaryotic translation initiation factor 6
MAVRASFENNCEIGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIG
RMCVGNRHGLLVPNNTTDQELQHIRNSLPDTVQIRRVEERLSALGNVTTCNDYVALVHPD
LDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVP
LVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAQPSTIATSMRDSL
IDSLT
Number of residues
245
Molecular Weight
26598.84
Theoretical pI
Not Available
GO Classification
Functions
ribosomal large subunit binding / ribosome binding / translation initiation factor activity
Processes
assembly of large subunit precursor of preribosome / gene silencing by miRNA / maturation of 5.8S rRNA / maturation of LSU-rRNA / mature ribosome assembly / miRNA mediated inhibition of translation / positive regulation of translation / regulation of fatty acid biosynthetic process / regulation of glycolytic process / regulation of megakaryocyte differentiation / regulation of reactive oxygen species metabolic process / response to insulin / ribosomal subunit export from nucleus
Components
cytoplasm / cytosol / extracellular exosome / nucleolus / nucleoplasm / nucleus / preribosome, large subunit precursor
General Function
Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity).
Specific Function
Ribosomal large subunit binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0049660|Eukaryotic translation initiation factor 6 (EIF6)
ATGGCGGTCCGAGCTTCGTTCGAGAACAACTGTGAGATCGGCTGCTTTGCCAAGCTCACC
AACACCTACTGTCTGGTAGCGATCGGAGGCTCAGAGAACTTCTACAGTGTGTTCGAGGGC
GAGCTCTCCGATACCATCCCCGTGGTGCACGCGTCTATCGCCGGCTGCCGCATCATCGGG
CGCATGTGTGTGGGGAACAGGCACGGTCTCCTGGTACCCAACAATACCACCGACCAGGAG
CTGCAACACATTCGCAACAGCCTCCCAGACACAGTGCAGATTAGGCGGGTGGAGGAGCGG
CTCTCAGCCTTGGGCAATGTCACCACCTGCAATGACTACGTGGCCTTGGTCCACCCAGAC
TTGGACAGGGAGACAGAAGAAATTCTGGCAGATGTGCTCAAGGTGGAAGTCTTCAGACAG
ACAGTGGCCGACCAGGTGCTAGTAGGAAGCTACTGTGTCTTCAGCAATCAGGGAGGGCTG
GTGCATCCCAAGACTTCAATTGAAGACCAGGATGAGCTGTCCTCTCTTCTTCAAGTCCCC
CTTGTGGCGGGGACTGTGAACCGAGGCAGTGAGGTGATTGCTGCTGGGATGGTGGTGAAT
GACTGGTGTGCCTTCTGTGGCCTGGACACAACCAGCACAGAGCTGTCAGTGGTGGAGAGT
GTCTTCAAGCTGAATGAAGCCCAGCCTAGCACCATTGCCACCAGCATGCGGGATTCCCTC
ATTGACAGCCTCACCTGA
Chromosome Location
20
Locus
20q11.22
External Identifiers
ResourceLink
UniProtKB IDP56537
UniProtKB Entry NameIF6_HUMAN
HGNC IDHGNC:6159
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails