UDP-N-acetylenolpyruvoylglucosamine reductase

Details

Name

UDP-N-acetylenolpyruvoylglucosamine reductase

Synonyms

• 1.3.1.98
• UDP-N-acetylmuramate dehydrogenase

Gene Name

murB

Organism

Staphylococcus aureus (strain MW2)

Amino acid sequence

>lcl|BSEQ0012088|UDP-N-acetylenolpyruvoylglucosamine reductase
MINKDIYQALQQLIPNEKIKVDEPLKRYTYTKTGGNADFYITPTKNEEVQAVVKYAYQNE
IPVTYLGNGSNIIIREGGIRGIVISLLSLDHIEVSDDAIIAGSGAAIIDVSRVARDYALT
GLEFACGIPGSIGGAVYMNAGAYGGEVKDCIDYALCVNEQGSLIKLTTKELELDYRNSII
QKEHLVVLEAAFTLAPGKMTEIQAKMDDLTERRESKQPLEYPSCGSVFQRPPGHFAGKLI
QDSNLQGHRIGGVEVSTKHAGFMVNVDNGTATDYENLIHYVQKTVKEKFGIELNREVRII
GEHPKES

Number of residues

307

Molecular Weight

33797.18

Theoretical pI

5.25

GO Classification

Functions

flavin adenine dinucleotide binding / UDP-N-acetylmuramate dehydrogenase activity

Processes

cell cycle / cell division / cell wall organization / peptidoglycan biosynthetic process / regulation of cell shape

Components

cytoplasm

General Function

Udp-n-acetylmuramate dehydrogenase activity

Specific Function

Cell wall formation.

Pfam Domain Function

• FAD_binding_4 (PF01565)
• MurB_C (PF02873)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0005807|924 bp
TTACGATTCCTTTGGATGTTCACCAATAATGCGAACTTCACGATTTAATTCAATGCCAAA
TTTTTCTTTGACGGTCTTTTGTACATAATGAATAAGGTTTTCATAATCTGTAGCAGTTCC
ATTGTCTACATTTACCATAAAACCAGCGTGTTTAGTTGAAACTTCAACGCCGCCAATACG
GTGACCTTGCAAATTAGAATCTTGTATCAATTTACCTGCAAAATGACCAGGCGGTCTTTG
GAATACACTACCACATGAAGGATACTCTAAAGGTTGTTTAGATTCTCTACGTTCTGTTAA
ATCATCCATTTTAGCTTGTATTTCAGTCATTTTACCAGGAGCTAAAGTAAATGCAGCTTC
TAATACAACTAAGTGTTCTTTTTGAATAATGCTATTACGATAATCTAACTCTAATTCTTT
TGTTGTAAGTTTAATTAACGAGCCTTGTTCGTTTACGCAAAGCGCATAGTCTATACAATC
TTTAACTTCGCCACCATAAGCGCCAGCATTCATATACACTGCACCACCGATTGAACCTGG
AATACCACATGCAAATTCAAGGCCAGTAAGTGCGTAATCACGAGCAACACGTGAGACATC
AATAATTGCAGCGCCGCTACCGGCTATTATCGCATCATCAGATACTTCGATATGATCTAG
TGATAATAAACTAATTACAATGCCACGAATACCACCTTCACGGATAATAATATTTGAGCC
ATTTCCTAAATATGTAACAGGAATCTCATTTTGATAGGCATATTTAACAACTGCTTGTAC
TTCTTCATTTTTAGTAGGGGTAATATAAAAGTCGGCATTACCACCTGTTTTAGTATAAGT
GTATCGTTTTAAAGGTTCATCAACTTTAATTTTTTCATTTGGGATAAGTTGTTGTAAAGC
TTGATAGATGTCTTTATTTATCAC

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P61432
UniProtKB Entry Name	MURB_STAAW
GenBank Gene ID	BA000033

General References

1. Baba T, Takeuchi F, Kuroda M, Yuzawa H, Aoki K, Oguchi A, Nagai Y, Iwama N, Asano K, Naimi T, Kuroda H, Cui L, Yamamoto K, Hiramatsu K: Genome and virulence determinants of high virulence community-acquired MRSA. Lancet. 2002 May 25;359(9320):1819-27. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03147	Flavin adenine dinucleotide	approved	unknown		Details