Deoxyribodipyrimidine photo-lyase

Details

Name
Deoxyribodipyrimidine photo-lyase
Synonyms
  • 4.1.99.3
  • DNA photolyase
  • Photoreactivating enzyme
Gene Name
phr
Organism
Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
Amino acid sequence
>lcl|BSEQ0011419|Deoxyribodipyrimidine photo-lyase
MGPLLVWHRGDLRLHDHPALLEALARGPVVGLVVLDPNNLKTTPRRRAWFLENVRALREA
YRARGGALWVLEGLPWEKVPEAARRLKAKAVYALTSHTPYGRYRDGRVREALPVPLHLLP
APHLLPPDLPRAYRVYTPFSRLYRGAAPPLPPPEALPKGPEEGEIPREDPGLPLPEPGEE
AALAGLRAFLEAKLPRYAEERDRLDGEGGSRLSPYFALGVLSPRLAAWEAERRGGEGARK
WVAELLWRDFSYHLLYHFPWMAERPLDPRFQAFPWQEDEALFQAWYEGKTGVPLVDAAMR
ELHATGFLSNRARMNAAQFAVKHLLLPWKRCEEAFRHLLLDGDRAVNLQGWQWAGGLGVD
AAPYFRVFNPVLQGERHDPEGRWLKRWAPEYPSYAPKDPVVDLEEARRRYLRLARDLARG
Number of residues
420
Molecular Weight
47900.455
Theoretical pI
9.66
GO Classification
Functions
deoxyribodipyrimidine photo-lyase activity / DNA binding / nucleotide binding
Processes
DNA repair / protein-chromophore linkage
General Function
Nucleotide binding
Specific Function
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011420|Deoxyribodipyrimidine photo-lyase (phr)
ATGGGCCCCCTTCTCGTCTGGCACCGGGGCGACCTCCGCCTCCACGACCACCCGGCCCTC
CTGGAGGCCCTGGCCCGGGGGCCGGTGGTGGGCCTCGTGGTCCTGGACCCCAACAACCTG
AAGACCACCCCGAGGCGGCGGGCCTGGTTCCTGGAAAACGTCCGGGCCCTGCGGGAGGCC
TACCGGGCCCGGGGCGGGGCCCTTTGGGTCCTGGAGGGCCTCCCTTGGGAGAAGGTGCCC
GAGGCGGCGAGGCGGCTTAAGGCCAAGGCCGTCTACGCCCTCACGAGCCACACCCCTTAC
GGCCGCTACCGGGACGGGAGGGTGCGGGAGGCCCTCCCCGTGCCCCTCCACCTCCTCCCC
GCCCCCCACCTCCTCCCCCCCGACCTCCCCCGGGCCTACCGGGTTTACACCCCCTTTAGC
CGCCTCTACCGGGGGGCCGCCCCGCCCCTTCCCCCTCCCGAGGCCCTGCCCAAGGGGCCA
GAGGAGGGGGAAATCCCCCGGGAAGACCCGGGGCTTCCCCTCCCCGAGCCGGGGGAGGAG
GCGGCCCTCGCGGGGCTTCGGGCCTTCCTCGAGGCCAAGCTCCCCCGCTACGCCGAGGAG
CGGGACCGGCTGGACGGAGAGGGGGGCTCGAGGCTCTCCCCCTACTTCGCCCTAGGGGTC
CTCTCCCCCAGGCTCGCCGCCTGGGAGGCGGAAAGGCGGGGCGGGGAGGGAGCGAGGAAG
TGGGTGGCGGAGCTCCTCTGGCGGGACTTCTCCTACCACCTCCTCTACCACTTCCCCTGG
ATGGCGGAAAGGCCCCTGGACCCGAGGTTCCAGGCCTTCCCCTGGCAGGAGGACGAGGCC
CTCTTCCAAGCTTGGTACGAGGGGAAGACGGGCGTCCCCCTGGTGGACGCCGCCATGCGG
GAGCTCCACGCCACGGGCTTCCTCTCCAACCGGGCCCGGATGAACGCGGCCCAGTTCGCG
GTGAAGCACCTCCTCCTCCCCTGGAAAAGGTGCGAGGAGGCCTTCCGCCACCTCCTCCTG
GACGGGGACCGGGCGGTGAACCTCCAGGGCTGGCAGTGGGCGGGGGGCCTGGGGGTGGAC
GCCGCCCCCTACTTCCGGGTCTTCAACCCGGTGCTCCAGGGGGAAAGGCACGACCCCGAG
GGGAGGTGGCTTAAGCGCTGGGCCCCGGAATACCCCTCCTACGCCCCCAAGGACCCCGTG
GTGGACCTGGAGGAGGCGAGAAGGCGCTACCTGCGCCTGGCGAGGGATCTCGCCCGAGGG
TAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP61497
UniProtKB Entry NamePHR_THET8
GenBank Protein ID15080709
GenBank Gene IDAB064548
General References
  1. Torizawa T, Ueda T, Kuramitsu S, Hitomi K, Todo T, Iwai S, Morikawa K, Shimada I: Investigation of the cyclobutane pyrimidine dimer (CPD) photolyase DNA recognition mechanism by NMR analyses. J Biol Chem. 2004 Jul 30;279(31):32950-6. Epub 2004 May 28. [Article]
  2. Weber S: Light-driven enzymatic catalysis of DNA repair: a review of recent biophysical studies on photolyase. Biochim Biophys Acta. 2005 Feb 25;1707(1):1-23. [Article]
  3. Komori H, Masui R, Kuramitsu S, Yokoyama S, Shibata T, Inoue Y, Miki K: Crystal structure of thermostable DNA photolyase: pyrimidine-dimer recognition mechanism. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13560-5. Epub 2001 Nov 13. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03147Flavin adenine dinucleotideapprovedunknownDetails
DB03462ThymineexperimentalunknownDetails