GTP-binding nuclear protein Ran

Details

Name
GTP-binding nuclear protein Ran
Synonyms
  • Androgen receptor-associated protein 24
  • ARA24
  • GTPase Ran
  • Ras-like protein TC4
  • Ras-related nuclear protein
Gene Name
RAN
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009480|GTP-binding nuclear protein Ran
MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIK
FNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLC
GNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMP
ALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
Number of residues
216
Molecular Weight
24422.965
Theoretical pI
Not Available
GO Classification
Functions
androgen receptor binding / chromatin binding / GDP binding / GTP binding / GTPase activity / poly(A) RNA binding / transcription coactivator activity
Processes
actin cytoskeleton organization / androgen receptor signaling pathway / cell division / cellular protein complex localization / cellular response to mineralocorticoid stimulus / DNA metabolic process / gene expression / gene silencing by RNA / hippocampus development / intracellular transport of virus / mitotic nuclear division / mitotic spindle organization / positive regulation of protein binding / positive regulation of transcription, DNA-templated / pre-miRNA export from nucleus / protein export from nucleus / protein import into nucleus / protein import into nucleus, translocation / protein localization to nucleolus / ribosomal large subunit export from nucleus / ribosomal small subunit export from nucleus / signal transduction / small GTPase mediated signal transduction / small molecule metabolic process / spermatid development / tRNA processing / viral life cycle / viral process
Components
centriole / cytoplasm / cytosol / extracellular exosome / male germ cell nucleus / manchette / melanosome / membrane / midbody / nuclear pore / nucleolus / nucleoplasm / nucleus / recycling endosome / RNA nuclear export complex / sperm flagellum
General Function
Transcription coactivator activity
Specific Function
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0013187|GTP-binding nuclear protein Ran (RAN)
ATGTTTGATGTAACATCGAGAGTTACTTACAAGAATGTGCCTAACTGGCATAGAGATCTG
GTACGAGTGTGTGAAAACATCCCCATTGTGTTGTGTGGCAACAAAGTGGATATTAAGGAC
AGGAAAGTGAAGGCGAAATCCATTGTCTTCCACCGAAAGAAGAATCTTCAGTACTACGAC
ATTTCTGCCAAAAGTAACTACAACTTTGAAAAGCCCTTCCTCTGGCTTGCTAGGAAGCTC
ATTGGAGACCCTAACTTGGAATTTGTTGCCATGCCTGCTCTCGCCCCACCAGAAGTTGTC
ATGGACCCAGCTTTGGCAGCACAGTATGAGCACGACTTAGAGGTTGCTCAGACAACTGCT
CTCCCGGATGAGGATGATGACCTGTGA
Chromosome Location
12
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP62826
UniProtKB Entry NameRAN_HUMAN
HGNC IDHGNC:9846
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails