14-3-3 protein zeta/delta

Details

Name
14-3-3 protein zeta/delta
Synonyms
  • KCIP-1
  • Protein kinase C inhibitor protein 1
Gene Name
YWHAZ
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002335|14-3-3 protein zeta/delta
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWR
VVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLK
MKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYE
ILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAG
EGGEN
Number of residues
245
Molecular Weight
27744.84
Theoretical pI
4.43
GO Classification
Functions
identical protein binding / poly(A) RNA binding / protein kinase binding / transcription factor binding / ubiquitin protein ligase binding
Processes
apoptotic process / blood coagulation / establishment of Golgi localization / gene expression / Golgi reassembly / intrinsic apoptotic signaling pathway / membrane organization / negative regulation of apoptotic process / platelet activation / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / programmed cell death / protein targeting / regulation of mRNA stability / signal transduction / small GTPase mediated signal transduction / transcription initiation from RNA polymerase II promoter
Components
blood microparticle / cytoplasm / cytoplasmic vesicle membrane / cytosol / extracellular exosome / extracellular space / focal adhesion / melanosome / mitochondrion / nucleoplasm / nucleus
General Function
Ubiquitin protein ligase binding
Specific Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016337|14-3-3 protein zeta/delta (YWHAZ)
ATGGATAAAAATGAGCTGGTTCAGAAGGCCAAACTGGCCGAGCAGGCTGAGCGATATGAT
GACATGGCAGCCTGCATGAAGTCTGTAACTGAGCAAGGAGCTGAATTATCCAATGAGGAG
AGGAATCTTCTCTCAGTTGCTTATAAAAATGTTGTAGGAGCCCGTAGGTCATCTTGGAGG
GTCGTCTCAAGTATTGAACAAAAGACGGAAGGTGCTGAGAAAAAACAGCAGATGGCTCGA
GAATACAGAGAGAAAATTGAGACGGAGCTAAGAGATATCTGCAATGATGTACTGTCTCTT
TTGGAAAAGTTCTTGATCCCCAATGCTTCACAAGCAGAGAGCAAAGTCTTCTATTTGAAA
ATGAAAGGAGATTACTACCGTTACTTGGCTGAGGTTGCCGCTGGTGATGACAAGAAAGGG
ATTGTCGATCAGTCACAACAAGCATACCAAGAAGCTTTTGAAATCAGCAAAAAGGAAATG
CAACCAACACATCCTATCAGACTGGGTCTGGCCCTTAACTTCTCTGTGTTCTATTATGAG
ATTCTGAACTCCCCAGAGAAAGCCTGCTCTCTTGCAAAGACAGCTTTTGATGAAGCCATT
GCTGAACTTGATACATTAAGTGAAGAGTCATACAAAGACAGCACGCTAATAATGCAATTA
CTGAGAGACAACTTGACATTGTGGACATCGGATACCCAAGGAGACGAAGCTGAAGCAGGA
GAAGGAGGGGAAAATTAA
Chromosome Location
8
Locus
8q23.1
External Identifiers
ResourceLink
UniProtKB IDP63104
UniProtKB Entry Name1433Z_HUMAN
GenBank Protein ID189953
GenBank Gene IDM86400
GenAtlas IDYWHAZ
HGNC IDHGNC:12855
General References
  1. Zupan LA, Steffens DL, Berry CA, Landt M, Gross RW: Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis. J Biol Chem. 1992 May 5;267(13):8707-10. [Article]
  2. Seluja GA, Elias L, Pietromonaco SF: Two unique 5' untranslated regions in mRNAs encoding human 14-3-3 zeta: differential expression in hemopoietic cells. Biochim Biophys Acta. 1998 Feb 11;1395(3):281-7. [Article]
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  18. Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC: Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1222-7. Epub 2005 Jan 11. [Article]
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  35. Yuasa K, Ota R, Matsuda S, Isshiki K, Inoue M, Tsuji A: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. Biochem Biophys Res Commun. 2015 Aug 14;464(1):70-5. doi: 10.1016/j.bbrc.2015.05.105. Epub 2015 Jun 3. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails