Probable N-acetylneuraminic acid outer membrane channel protein NanC
Details
- Name
- Probable N-acetylneuraminic acid outer membrane channel protein NanC
- Synonyms
- NanR-regulated channel
- Porin NanC
- yjhA
- Gene Name
- nanC
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0007941|Probable N-acetylneuraminic acid outer membrane channel protein NanC MKKAKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESN TWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDAT KDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDY RYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
- Number of residues
- 238
- Molecular Weight
- 27887.855
- Theoretical pI
- 8.71
- GO Classification
- Functionsoligosaccharide transporting porin activity / porin activity / sialic acid transmembrane transporter activityProcessescarbohydrate derivative transport / carboxylic acid transport / oligosaccharide transport / transmembrane transportComponentsintegral component of cell outer membrane / pore complex
- General Function
- Sialic acid transmembrane transporter activity
- Specific Function
- Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.
- Pfam Domain Function
- KdgM (PF06178)
- Transmembrane Regions
- 25-33 38-48 53-64 76-87 92-102 106-118 123-134 150-160 165-176 188-198 204-212 228-236
- Cellular Location
- Cell outer membrane
- Gene sequence
>lcl|BSEQ0012906|Probable N-acetylneuraminic acid outer membrane channel protein NanC (nanC) ATGAAAAAGGCTAAAATACTTTCTGGCGTATTATTACTGTGCTTTTCGTCCCCATTAATT TCTCAGGCTGCGACACTGGACGTACGTGGTGGATATCGTAGTGGAAGCCACGCCTATGAG ACTCGACTCAAAGTCAGTGAGGGATGGCAAAATGGATGGTGGGCAAGCATGGAAAGTAAT ACCTGGAATACCATTCATGATAATAAAAAGGAAAATGCCGCACTCAATGATGTTCAGGTT GAAGTTAATTACGCGATTAAACTTGATGATCAATGGACGGTGCGCCCGGGAATGTTAACG CATTTTAGCAGCAACGGCACACGCTACGGACCCTACGTAAAACTGTCCTGGGACGCGACA AAAGATCTTAATTTTGGCATTCGCTATCGTTACGACTGGAAAGCTTACCGACAACAAGAC TTATCCGGTGATATGTCTCGTGATAACGTTCATCGTTGGGATGGATATGTCACTTACCAT ATTAATAGTGATTTCACCTTCGCATGGCAAACGACGCTATACAGCAAACAGAACGATTAT CGCTATGCAAACCATAAGAAATGGGCGACGGAAAATGCATTTGTTCTACAATACCATATG ACGCCCGATATTACGCCATACATAGAATATGACTACCTTGACCGTCAGGGTGTTTACAAC GGCAGAGATAATTTATCGGAAAACAGTTATCGCATTGGTGTGTCATTTAAACTGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P69856 UniProtKB Entry Name NANC_ECOLI GenBank Protein ID 1263173 GenBank Gene ID U14003 - General References
- Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Condemine G, Berrier C, Plumbridge J, Ghazi A: Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. J Bacteriol. 2005 Mar;187(6):1959-65. [Article]
- Wirth C, Condemine G, Boiteux C, Berneche S, Schirmer T, Peneff CM: NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. J Mol Biol. 2009 Dec 11;394(4):718-31. doi: 10.1016/j.jmb.2009.09.054. Epub 2009 Sep 29. [Article]