Probable N-acetylneuraminic acid outer membrane channel protein NanC

Details

Name
Probable N-acetylneuraminic acid outer membrane channel protein NanC
Synonyms
  • NanR-regulated channel
  • Porin NanC
  • yjhA
Gene Name
nanC
Organism
Escherichia coli (strain K12)
Amino acid sequence
>lcl|BSEQ0007941|Probable N-acetylneuraminic acid outer membrane channel protein NanC
MKKAKILSGVLLLCFSSPLISQAATLDVRGGYRSGSHAYETRLKVSEGWQNGWWASMESN
TWNTIHDNKKENAALNDVQVEVNYAIKLDDQWTVRPGMLTHFSSNGTRYGPYVKLSWDAT
KDLNFGIRYRYDWKAYRQQDLSGDMSRDNVHRWDGYVTYHINSDFTFAWQTTLYSKQNDY
RYANHKKWATENAFVLQYHMTPDITPYIEYDYLDRQGVYNGRDNLSENSYRIGVSFKL
Number of residues
238
Molecular Weight
27887.855
Theoretical pI
8.71
GO Classification
Functions
oligosaccharide transporting porin activity / porin activity / sialic acid transmembrane transporter activity
Processes
carbohydrate derivative transport / carboxylic acid transport / oligosaccharide transport / transmembrane transport
Components
integral component of cell outer membrane / pore complex
General Function
Sialic acid transmembrane transporter activity
Specific Function
Outer membrane channel protein allowing the entry of N-acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria (Probable). NanC proteins form high-conductance channels which are open at low membrane potentials and which have a weak anion selectivity.
Pfam Domain Function
Transmembrane Regions
25-33 38-48 53-64 76-87 92-102 106-118 123-134 150-160 165-176 188-198 204-212 228-236
Cellular Location
Cell outer membrane
Gene sequence
>lcl|BSEQ0012906|Probable N-acetylneuraminic acid outer membrane channel protein NanC (nanC)
ATGAAAAAGGCTAAAATACTTTCTGGCGTATTATTACTGTGCTTTTCGTCCCCATTAATT
TCTCAGGCTGCGACACTGGACGTACGTGGTGGATATCGTAGTGGAAGCCACGCCTATGAG
ACTCGACTCAAAGTCAGTGAGGGATGGCAAAATGGATGGTGGGCAAGCATGGAAAGTAAT
ACCTGGAATACCATTCATGATAATAAAAAGGAAAATGCCGCACTCAATGATGTTCAGGTT
GAAGTTAATTACGCGATTAAACTTGATGATCAATGGACGGTGCGCCCGGGAATGTTAACG
CATTTTAGCAGCAACGGCACACGCTACGGACCCTACGTAAAACTGTCCTGGGACGCGACA
AAAGATCTTAATTTTGGCATTCGCTATCGTTACGACTGGAAAGCTTACCGACAACAAGAC
TTATCCGGTGATATGTCTCGTGATAACGTTCATCGTTGGGATGGATATGTCACTTACCAT
ATTAATAGTGATTTCACCTTCGCATGGCAAACGACGCTATACAGCAAACAGAACGATTAT
CGCTATGCAAACCATAAGAAATGGGCGACGGAAAATGCATTTGTTCTACAATACCATATG
ACGCCCGATATTACGCCATACATAGAATATGACTACCTTGACCGTCAGGGTGTTTACAAC
GGCAGAGATAATTTATCGGAAAACAGTTATCGCATTGGTGTGTCATTTAAACTGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP69856
UniProtKB Entry NameNANC_ECOLI
GenBank Protein ID1263173
GenBank Gene IDU14003
General References
  1. Burland V, Plunkett G 3rd, Sofia HJ, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome VI: DNA sequence of the region from 92.8 through 100 minutes. Nucleic Acids Res. 1995 Jun 25;23(12):2105-19. [Article]
  2. Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
  3. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
  4. Condemine G, Berrier C, Plumbridge J, Ghazi A: Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. J Bacteriol. 2005 Mar;187(6):1959-65. [Article]
  5. Wirth C, Condemine G, Boiteux C, Berneche S, Schirmer T, Peneff CM: NanC crystal structure, a model for outer-membrane channels of the acidic sugar-specific KdgM porin family. J Mol Biol. 2009 Dec 11;394(4):718-31. doi: 10.1016/j.jmb.2009.09.054. Epub 2009 Sep 29. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04147Dodecyldimethylamine N-oxideexperimentalunknownDetails