DNA gyrase subunit A
Details
- Name
- DNA gyrase subunit A
- Synonyms
- 5.99.1.3
- Gene Name
- gyrA
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- Amino acid sequence
>lcl|BSEQ0017204|DNA gyrase subunit A MQDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKP HKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRY TEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNI PPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVL RSRTEIETTKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRF VIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVV RRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSKFKLSERQSQA ILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKR RTELMIGQVLSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDD FVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVIN VESDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDII IGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKR TVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQT GRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGEA
- Number of residues
- 822
- Molecular Weight
- 92052.595
- Theoretical pI
- 6.07
- GO Classification
- FunctionsATP binding / DNA binding / DNA topoisomerase type II (ATP-hydrolyzing) activityProcessesDNA topological change / DNA-dependent DNA replicationComponentschromosome / cytoplasm
- General Function
- Dna topoisomerase type ii (atp-hydrolyzing) activity
- Specific Function
- DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017205|DNA gyrase subunit A (gyrA) ATGCAGGATAAAAATTTAGTGAATGTCAATCTGACAAAGGAGATGAAGGCAAGTTTTATC GACTACGCCATGAGTGTTATCGTAGCGCGAGCTCTTCCTGATGTTCGAGATGGCTTAAAA CCTGTTCACCGTCGCATTCTCTACGGAATGAATGAATTGGGTGTGACCCCAGACAAACCC CATAAAAAATCTGCTCGTATTACAGGGGATGTCATGGGTAAATATCACCCACACGGGGAT TCCTCTATTTATGAAGCCATGGTCCGTATGGCTCAATGGTGGAGCTACCGTTACATGCTT GTAGATGGTCATGGGAATTTTGGTTCCATGGATGGAGATAGTGCTGCCGCTCAACGTTAT ACCGAGGCACGTATGAGCAAGATTGCTCTGGAAATGCTTCGTGATATCAACAAAAATACA GTTGATTTCGTTGATAACTATGATGCCAATGAACGGGAACCCTTGGTCTTGCCAGCGCGT TTTCCAAACCTTTTGGTTAATGGAGCAACTGGTATCGCGGTTGGGATGGCAACCAATATT CCACCTCATAATCTGGGTGAAACCATTGATGCAGTGAAGTTGGTCATGGATAATCCTGAA GTGACTACCAAGGACTTGATGGAAGTCTTGCCTGGACCAGATTTTCCAACTGGTGCTCTT GTCATGGGGAAATCAGGTATCCATAAGGCTTATGAAACAGGTAAAGGTTCGATTGTCCTA CGTTCTCGTACAGAGATTGAAACGACTAAGACTGGTCGTGAGCGTATCGTTGTAACAGAA TTTCCTTACATGGTCAATAAAACCAAGGTGCATGAGCATATTGTTCGCTTGGTTCAGGAA AAACGCATTGAGGGTATCACAGCAGTACGTGATGAGTCAAACCGTGAAGGTGTTCGATTT GTTATTGAAGTCAAGCGCGACGCCTCAGCCAATGTTATTCTCAATAACCTCTTCAAAATG ACCCAAATGCAAACCAATTTTGGTTTCAATATGCTCGCTATCCAAAATGGTATACCGAAA ATTTTGTCTCTTCGTCAGATTTTGGATGCTTATATCGAGCACCAAAAAGAAGTGGTTGTT CGTCGTACACGTTTTGATAAGGAAAAAGCGGAAGCGCGCGCTCATATCTTAGAAGGTCTC TTGATTGCGCTAGACCATATCGACGAAGTGATTCGTATCATCCGTGCTAGTGAAACGGAT GCGGAAGCTCAAGCTGAGTTGATGAGCAAGTTTAAGCTTTCTGAACGTCAAAGTCAAGCT ATCCTTGATATGCGTCTTCGTCGTTTGACAGGTTTGGAACGCGATAAGATTCAATCTGAG TATGATGACCTCTTGGCTCTGATTGCGGATTTAGCAGATATTCTTGCTAAGCCTGAACGT GTTTCTCAAATTATCAAAGACGAATTGGATGAAGTTAAACGTAAATTTTCTGATAAGCGC CGTACAGAGTTGATGATTGGACAGGTCTTGAGTCTCGAGGATGAGGACTTGATTGAAGAA TCGGATGTCTTGATTACCCTTTCTAACAGAGGCTACATTAAGCGTTTGGATCAGGACGAG TTCACTGCTCAAAAACGTGGGGGTCGTGGTGTCCAAGGAACGGGAGTGAAAGATGATGAC TTTGTTCGTGAGTTAGTGTCAACTAGCACCCATGATCATCTGCTCTTCTTCACAAACAAG GGACGTGTCTATCGTCTTAAAGGTTATGAAATTCCTGAGTATGGTCGGACTGCCAAAGGG CTACCAGTAGTCAATCTCTTGAAATTGGATGAAGACGAAAGTATTCAGACGGTTATCAAT GTTGAGTCTGATCGCAGTGATGATGCTTATCTCTTCTTTACAACCCGTCACGGTATTGTG AAGAGAACCAGTGTTAAGGAGTTTGCCAATATTCGTCAAAATGGTCTCAAAGCGCTGAAT TTAAAGGATGAAGATGAGTTAATCAATGTCTTGTTGGCAGAAGGAGATATGGATATTATC ATTGGTACCAAGTTTGGTTATGCAGTTCGCTTTAATCAATCAGCCGTTCGTGGTATGAGC CGTATCGCCACTGGTGTGAAAGGTGTTAACCTTCGTGAAGGAGACACAGTTGTTGGTGCC AGCTTGATTACTGATCAAGATGAGGTTCTTATTATCACAGAAAAAGGATATGGTAAGCGT ACAGTCGCTACTGAATACCCAACAAAAGGTCGTGGTGGTAAGGGAATGCAGACAGCTAAA ATTACCGAAAAAAATGGCTTGCTGGCCGGTCTTATGACTGTTCAAGGGGATGAGGATTTG ATGATTATCACTGATACAGGTGTCATGATTCGAACCAATCTTGCCAATATTTCACAAACA GGACGTGCAACTATGGGAGTTAAAGTAATGCGCCTGGATCAAGATGCTCAGATAGTGACT TTCACAACGGTTGCGGTGGCAGAAAAAGAAGAAGTTGGGACAGAAAACGAAACAGAAGGT GAAGCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P72524 UniProtKB Entry Name GYRA_STRPN GenBank Protein ID 14971465 GenBank Gene ID AE005672 - General References
- Tettelin H, Nelson KE, Paulsen IT, Eisen JA, Read TD, Peterson S, Heidelberg J, DeBoy RT, Haft DH, Dodson RJ, Durkin AS, Gwinn M, Kolonay JF, Nelson WC, Peterson JD, Umayam LA, White O, Salzberg SL, Lewis MR, Radune D, Holtzapple E, Khouri H, Wolf AM, Utterback TR, Hansen CL, McDonald LA, Feldblyum TV, Angiuoli S, Dickinson T, Hickey EK, Holt IE, Loftus BJ, Yang F, Smith HO, Venter JC, Dougherty BA, Morrison DA, Hollingshead SK, Fraser CM: Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science. 2001 Jul 20;293(5529):498-506. [Article]