Metallothionein-1X
Details
- Name
- Metallothionein-1X
- Synonyms
- Metallothionein-IX
- MT-1X
- MT-IX
- Gene Name
- MT1X
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049466|Metallothionein-1X MDPNCSCSPVGSCACAGSCKCKECKCTSCKKSCCSCCPVGCAKCAQGCICKGTSDKCSCC A
- Number of residues
- 61
- Molecular Weight
- 6068.14
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion binding / zinc ion bindingProcessescellular response to cadmium ion / cellular response to erythropoietin / cellular response to zinc ion / negative regulation of growth / response to metal ionComponentscytoplasm / nucleus / perinuclear region of cytoplasm
- General Function
- Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).
- Specific Function
- Metal ion binding
- Pfam Domain Function
- Metallothio (PF00131)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0049467|Metallothionein-1X (MT1X) ATGGACCCCAACTGCTCCTGCTCGCCTGTTGGCTCCTGTGCCTGTGCCGGCTCCTGCAAA TGCAAAGAGTGCAAATGCACCTCCTGCAAGAAGAGCTGCTGCTCCTGCTGCCCTGTGGGC TGTGCCAAGTGTGCCCAGGGCTGCATCTGCAAAGGGACGTCAGACAAGTGCAGCTGCTGT GCCTGA
- Chromosome Location
- 16
- Locus
- 16q13
- External Identifiers
Resource Link UniProtKB ID P80297 UniProtKB Entry Name MT1X_HUMAN HGNC ID HGNC:7405 - General References
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- Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
- Peng B, Gu Y, Xiong Y, Zheng G, He Z: Microarray-assisted pathway analysis identifies MT1X & NFkappaB as mediators of TCRP1-associated resistance to cisplatin in oral squamous cell carcinoma. PLoS One. 2012;7(12):e51413. doi: 10.1371/journal.pone.0051413. Epub 2012 Dec 10. [Article]