Fumarate reductase flavoprotein subunit

Details

Name
Fumarate reductase flavoprotein subunit
Synonyms
  • 1.3.5.4
  • FL cyt
  • Flavocytochrome c
Gene Name
Not Available
Organism
Shewanella oneidensis (strain MR-1)
Amino acid sequence
>lcl|BSEQ0016447|Fumarate reductase flavoprotein subunit
MFTRKIQKTALAMLISGAMAGTAYAAPEVLADFHGEMGGCDSCHVSDKGGVTNDNLTHEN
GQCVSCHGDLKELAAAAPKDKVSPHKSHLIGEIACTSCHKGHEKSVAYCDACHSFGFDMP
FGGKWERKFVPVDADKAAQDKAIAAGVKETTDVVIIGSGGAGLAAAVSARDAGAKVILLE
KEPIPGGNTKLAAGGMNAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVKVLANNS
SDSIDWLTSMGADMTDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDNAVKRGTDIRLNS
RVVRILEDASGKVTGVLVKGEYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKAT
NHPGATGDGLDVALQAGAATRDLEYIQAHPTYSPAGGVMITEAVRGNGAIVVNREGNRFM
NEITTRDKASAAILQQKGESAYLVFDDSIRKSLKAIEGYVHLNIVKEGKTIEELAKQIDV
PAAELAKTVTAYNGFVKSGKDAQFERPDLPRELVVAPFYALEIAPAVHHTMGGLVIDTKA
EVKSEKTGKPITGLYAAGEVTGGVHGANRLGGNAISDIVTYGRIAGASAAKFAKDN
Number of residues
596
Molecular Weight
62447.475
Theoretical pI
7.64
GO Classification
Functions
metal ion binding / succinate dehydrogenase activity
Components
periplasmic space
General Function
Succinate dehydrogenase activity
Specific Function
Catalyzes fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown, but evidence indicates that flavocytochrome c participates in electron transfer from formate to fumarate and possibly also to trimethylamine oxide (TMAO). This enzyme is essentially unidirectional (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Periplasm
Gene sequence
>lcl|BSEQ0016448|Fumarate reductase flavoprotein subunit
ATGTTCACAAGAAAGATTCAAAAAACAGCACTAGCCATGCTGATCTCTGGCGCAATGGCA
GGCACAGCCTATGCCGCTCCAGAAGTACTAGCCGATTTTCACGGTGAAATGGGTGGCTGC
GATAGCTGCCACGTATCAGACAAAGGTGGCGTGACTAACGACAACCTGACCCATGAGAAT
GGCCAATGTGTTAGCTGCCACGGTGACTTAAAAGAACTGGCTGCAGCAGCGCCTAAAGAT
AAAGTTTCTCCGCACAAATCTCACTTAATTGGTGAAATCGCTTGTACGAGCTGCCACAAA
GGCCACGAAAAATCAGTAGCTTATTGTGATGCTTGCCATAGCTTCGGCTTCGATATGCCA
TTTGGTGGCAAGTGGGAACGTAAGTTTGTACCTGTTGATGCAGACAAAGCAGCACAAGAT
AAAGCCATTGCTGCTGGTGTGAAAGAAACCACAGACGTTGTAATTATCGGCTCTGGTGGT
GCTGGTCTTGCCGCTGCCGTATCTGCCCGTGATGCTGGCGCGAAAGTGATTCTGTTAGAA
AAAGAACCTATCCCAGGTGGTAACACTAAACTGGCTGCCGGTGGTATGAACGCCGCAGAA
ACTAAGCCACAGGCTAAGTTAGGTATCGAAGATAAGAAACAAATCATGATCGACGACACT
ATGAAAGGTGGCCGCAACATCAACGATCCTGAATTAGTTAAAGTACTGGCTAACAACTCT
TCAGACTCAATCGATTGGTTAACCTCTATGGGTGCCGACATGACTGACGTGGGTCGTATG
GGTGGCGCGAGCGTTAACCGTAGTCACCGTCCAACCGGTGGTGCAGGTGTTGGTGCTCAC
GTAGCACAAGTGCTGTGGGACAACGCCGTTAAGCGTGGTACTGATATTCGCTTAAACAGC
CGCGTTGTGCGCATCCTTGAAGATGCAAGCGGTAAAGTGACCGGCGTTTTAGTGAAAGGT
GAATACACAGGTTACTATGTGATCAAAGCCGATGCAGTAGTCATTGCAGCAGGTGGTTTT
GCGAAAAACAACGAACGTGTTTCTAAATACGATCCTAAGTTAAAAGGCTTTAAAGCGACC
AACCACCCAGGTGCGACGGGTGACGGCTTAGACGTAGCTCTACAAGCGGGCGCAGCAACA
CGTGACTTAGAATACATCCAAGCTCACCCAACTTACTCTCCAGCGGGTGGCGTGATGATC
ACCGAGGCAGTACGTGGTAACGGTGCAATCGTGGTGAACCGTGAAGGTAATCGTTTTATG
AACGAAATCACCACCCGTGATAAAGCGTCTGCGGCGATTCTGCAACAAAAAGGTGAAAGC
GCTTACCTAGTATTCGATGACTCTATCCGTAAGAGCTTGAAGGCCATCGAAGGTTATGTT
CACCTGAACATTGTAAAAGAAGGTAAAACCATCGAAGAGTTAGCGAAACAAATCGATGTA
CCTGCAGCTGAATTGGCAAAAACAGTAACAGCCTACAACGGTTTCGTTAAATCAGGTAAA
GATGCTCAATTTGAACGTCCTGATTTACCACGTGAATTAGTGGTAGCTCCTTTCTACGCC
TTAGAAATTGCACCAGCGGTTCACCACACTATGGGTGGTCTGGTGATTGATACTAAAGCC
GAAGTGAAGAGTGAGAAAACCGGTAAACCTATCACTGGTTTATACGCTGCAGGCGAAGTG
ACTGGTGGTGTTCACGGTGCTAACCGTTTAGGTGGTAACGCTATCTCTGATATCGTCACC
TACGGCCGTATCGCGGGTGCATCTGCCGCTAAATTCGCTAAAGATAATTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP83223
UniProtKB Entry NameFRDA_SHEON
GenBank Protein ID24346572
GenBank Gene IDAE014299
General References
  1. Tsapin AI, Vandenberghe I, Nealson KH, Scott JH, Meyer TE, Cusanovich MA, Harada E, Kaizu T, Akutsu H, Leys D, Van Beeumen JJ: Identification of a small tetraheme cytochrome c and a flavocytochrome c as two of the principal soluble cytochromes c in Shewanella oneidensis strain MR1. Appl Environ Microbiol. 2001 Jul;67(7):3236-44. [Article]
  2. Heidelberg JF, Paulsen IT, Nelson KE, Gaidos EJ, Nelson WC, Read TD, Eisen JA, Seshadri R, Ward N, Methe B, Clayton RA, Meyer T, Tsapin A, Scott J, Beanan M, Brinkac L, Daugherty S, DeBoy RT, Dodson RJ, Durkin AS, Haft DH, Kolonay JF, Madupu R, Peterson JD, Umayam LA, White O, Wolf AM, Vamathevan J, Weidman J, Impraim M, Lee K, Berry K, Lee C, Mueller J, Khouri H, Gill J, Utterback TR, McDonald LA, Feldblyum TV, Smith HO, Venter JC, Nealson KH, Fraser CM: Genome sequence of the dissimilatory metal ion-reducing bacterium Shewanella oneidensis. Nat Biotechnol. 2002 Nov;20(11):1118-23. Epub 2002 Oct 7. [Article]
  3. Leys D, Tsapin AS, Nealson KH, Meyer TE, Cusanovich MA, Van Beeumen JJ: Structure and mechanism of the flavocytochrome c fumarate reductase of Shewanella putrefaciens MR-1. Nat Struct Biol. 1999 Dec;6(12):1113-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01677Fumaric acidinvestigationalunknownDetails
DB03147Flavin adenine dinucleotideapprovedunknownDetails
DB00518Albendazoleapproved, vet_approvedunknowninhibitorDetails