Adenylate kinase

Details

Name

Adenylate kinase

Synonyms

• 2.7.4.3
• Adenylate monophosphate kinase
• AK
• ATP-AMP transphosphorylase
• ATP:AMP phosphotransferase

Gene Name

adk

Organism

Sporosarcina globispora

Amino acid sequence

>lcl|BSEQ0016363|Adenylate kinase
MNIVLMGLPGAGKGTQADRIVEKYGTPHISTGDMFRAAIQEGTELGVKAKSFMDQGALVP
DEVTIGIVRERLSKSDCDNGFLLDGFPRTVPQAEALDQLLADMGRKIEHVLNIQVEKEEL
IARLTGRRICKVCGTSYHLLFNPPQVEGKCDKDGGELYQRADDNPDTVTNRLEVNMNQTA
PLLAFYDSKEVLVNINGQKDIKDVFKDLDVILQGNGQ

Number of residues

217

Molecular Weight

23888.06

Theoretical pI

4.74

GO Classification

Functions

adenylate kinase activity / ATP binding / metal ion binding

Processes

AMP salvage

Components

cytoplasm

General Function

Metal ion binding

Specific Function

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Pfam Domain Function

• ADK_lid (PF05191)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P84139
UniProtKB Entry Name	KAD_SPOGL

General References

1. Bae E, Phillips GN Jr: Structures and analysis of highly homologous psychrophilic, mesophilic, and thermophilic adenylate kinases. J Biol Chem. 2004 Jul 2;279(27):28202-8. Epub 2004 Apr 20. [Article]
2. Gilles AM, Glaser P, Perrier V, Meier A, Longin R, Sebald M, Maignan L, Pistotnik E, Barzu O: Zinc, a structural component of adenylate kinases from gram-positive bacteria. J Bacteriol. 1994 Jan;176(2):520-3. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01717	Bis(Adenosine)-5'-Pentaphosphate	experimental	unknown		Details