Actin-1

Details

Name
Actin-1
Synonyms
  • Actin I
  • PfACT1
Gene Name
Not Available
Organism
Plasmodium falciparum (isolate HB3)
Amino acid sequence
>lcl|BSEQ0051360|Actin-1
MGEEDVQALVVDNGSGNVKAGVAGDDAPRSVFPSIVGRPKNPGIMVGMEEKDAFVGDEAQ
TKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRAAPEEHPVLLTEAPLNPKGNRERM
TQIMFESFNVPAMYVAIQAVLSLYSSGRTTGIVLDSGDGVSHTVPIYEGYALPHAIMRLD
LAGRDLTEYLMKILHERGYGFSTSAEKEIVRDIKEKLCYIALNFDEEMKTSEQSSDIEKS
YELPDGNIITVGNERFRCPEALFQPSFLGKEAAGIHTTTFNSIKKCDVDIRKDLYGNIVL
SGGTTMYEGIGERLTRDITTLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITK
EEYDESGPSIVHRKCF
Number of residues
376
Molecular Weight
41870.305
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / structural constituent of cytoskeleton
Processes
actin polymerization-dependent cell motility involved in migration of symbiont in host
Components
actin filament / cytoplasm
General Function
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP86287
UniProtKB Entry NameACT1_PLAFX
General References
  1. Schuler H, Mueller AK, Matuschewski K: Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites. FEBS Lett. 2005 Jan 31;579(3):655-60. doi: 10.1016/j.febslet.2004.12.037. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails