Fatty acid metabolism regulator protein

Details

Name
Fatty acid metabolism regulator protein
Synonyms
  • ysiA
Gene Name
fadR
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0012133|Fatty acid metabolism regulator protein
MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIYLYFKNKEDILISLFKE
KMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAIVTQLELRQSNLELRQKIN
EILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTIDETVTTWVMNDQKYDLVALS
NSVLELLVSGIHNK
Number of residues
194
Molecular Weight
21978.335
Theoretical pI
6.53
GO Classification
Functions
DNA binding
Processes
fatty acid metabolic process / lipid catabolic process / regulation of transcription, DNA-templated / transcription, DNA-templated
Components
cytoplasm
General Function
Dna binding
Specific Function
Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifically inhibited by long chain fatty acyl-CoA compounds of 14-20 carbon atoms in length.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012134|Fatty acid metabolism regulator protein (fadR)
TTGAAGCAAAAACGGCCAAAGTATATGCAGATTATTGATGCAGCAGTAGAAGTCATTGCA
GAAAACGGCTACCACCAGTCACAGGTATCCAAAATTGCCAAACAAGCCGGGGTAGCGGAC
GGCACCATCTATCTCTATTTTAAAAACAAAGAAGATATTTTAATTTCTCTTTTCAAAGAA
AAAATGGGTCAATTTATTGAGCGGATGGAAGAGGACATTAAAGAAAAAGCAACAGCGAAA
GAGAAATTGGCGCTTGTGATTTCAAAGCATTTTTCCCTTTTAGCGGGTGACCATAATCTC
GCCATTGTCACGCAGCTTGAGCTCCGCCAATCCAACTTGGAGCTGCGCCAAAAAATCAAC
GAAATATTAAAAGGCTACTTAAATATTTTGGATGGCATTTTGACGGAAGGTATACAATCA
GGCGAAATAAAAGAAGGCCTCGATGTCCGCCTCGCCCGGCAGATGATTTTTGGAACGATT
GACGAAACTGTGACAACTTGGGTGATGAATGACCAAAAGTACGATCTCGTTGCGCTTTCA
AACAGCGTTTTAGAATTATTGGTATCCGGAATTCACAATAAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP94548
UniProtKB Entry NameFADR_BACSU
GenBank Gene IDZ75208
General References
  1. Wipat A, Carter N, Brignell SC, Guy BJ, Piper K, Sanders J, Emmerson PT, Harwood CR: The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism. Microbiology. 1996 Nov;142 ( Pt 11):3067-78. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Matsuoka H, Hirooka K, Fujita Y: Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation. J Biol Chem. 2007 Feb 23;282(8):5180-94. Epub 2006 Dec 22. [Article]
  4. Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R: The TetR family of transcriptional repressors. Microbiol Mol Biol Rev. 2005 Jun;69(2):326-56. [Article]
  5. Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ: Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins. 2005 Sep 1;60(4):787-96. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03264Dodecyl-CoaexperimentalunknownDetails