Pyruvate synthase
Details
- Name
- Pyruvate synthase
- Synonyms
- 1.2.7.1
- POR
- Pyruvate-ferredoxin oxidoreductase.
- Gene Name
- por
- Organism
- Desulfovibrio africanus
- Amino acid sequence
>lcl|BSEQ0019316|Pyruvate synthase MGKKMMTTDGNTATAHVAYAMSEVAAIYPITPSSTMGEEADDWAAQGRKNIFGQTLTIRE MQSEAGAAGAVHGALAAGALTTTFTASQGLLLMIPNMYKISGELLPGVFHVTARAIAAHA LSIFGDHQDIYAARQTGFAMLASSSVQEAHDMALVAHLAAIESNVPFMHFFDGFRTSHEI QKIEVLDYADMASLVNQKALAEFRAKSMNPEHPHVRGTAQNPDIYFQGREAANPYYLKVP GIVAEYMQKVASLTGRSYKLFDYVGAPDAERVIVSMGSSCETIEEVINHLAAKGEKIGLI KVRLYRPFVSEAFFAALPASAKVITVLDRTKEPGAPGDPLYLDVCSAFVERGEAMPKILA GRYGLGSKEFSPAMVKSVYDNMSGAKKNHFTVGIEDDVTGTSLPVDNAFADTTPKGTIQC QFWGLGADGTVGANKQAIKIIGDNTDLFAQGYFSYDSKKSGGITISHLRFGEKPIQSTYL VNRADYVACHNPAYVGIYDILEGIKDGGTFVLNSPWSSLEDMDKHLPSGIKRTIANKKLK FYNIDAVKIATDVGLGGRINMIMQTAFFKLAGVLPFEKAVDLLKKSIHKAYGKKGEKIVK MNTDAVDQAVTSLQEFKYPDSWKDAPAETKAEPMTNEFFKNVVKPILTQQGDKLPVSAFE ADGRFPLGTSQFEKRGVAINVPQWVPENCIQCNQCAFVCPHSAILPVLAKEEELVGAPAN FTALEAKGKELKGYKFRIQINTLDCMGCGNCADICPPKEKALVMQPLDTQRDAQVPNLEY AARIPVKSEVLPRDSLKGSQFQEPLMEFSGACSGCGETPYVRVITQLFGERMFIANATGC SSIWGASAPSMPYKTNRLGQGPAWGNSLFEDAAEYGFGMNMSMFARRTHLADLAAKALES DASGDVKEALQGWLAGKNDPIKSKEYGDKLKKLLAGQKDGLLGQIAAMSDLYTKKSVWIF GGDGWAYDIGYGGLDHVLASGEDVNVFVMDTEVYSNTGGQSSKATPTGAVAKFAAAGKRT GKKDLARMVMTYGYVYVATVSMGYSKQQFLKVLKEAESFPGPSLVIAYATCINQGLRKGM GKSQDVMNTAVKSGYWPLFRYDPRLAAQGKNPFQLDSKAPDGSVEEFLMAQNRFAVLDRS FPEDAKRLRAQVAHELDVRFKELEHMAATNIFESFAPAGGKADGSVDFGEGAEFCTRDDT PMMARPDSGEACDQNRAGTSEQQGDLSKRTKK
- Number of residues
- 1232
- Molecular Weight
- 133679.405
- Theoretical pI
- 6.81
- GO Classification
- Functions4 iron, 4 sulfur cluster binding / iron ion binding / pyruvate synthase activity / thiamine pyrophosphate bindingProcesseselectron transport chainComponentscytoplasm
- General Function
- Thiamine pyrophosphate binding
- Specific Function
- Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate. Required for the transfer of electrons from pyruvate to ferredoxin (PubMed:9294422, PubMed:7612653). Ferredoxin I and ferredoxin II, which are single 4Fe-4S cluster ferredoxins are the most effective electron carriers of POR (PubMed:7612653).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0005243|3699 bp ATGGGAAAGAAAATGATGACGACTGATGGCAATACAGCGACAGCGCACGTGGCGTATGCC ATGAGCGAAGTCGCCGCCATCTACCCCATCACCCCTTCCTCGACCATGGGCGAGGAGGCT GACGACTGGGCGGCGCAAGGACGCAAGAACATCTTTGGCCAGACCCTGACCATACGCGAA ATGCAGTCCGAGGCCGGCGCCGCCGGCGCGGTGCACGGGGCCCTGGCGGCCGGCGCCCTG ACCACGACCTTCACGGCGTCGCAGGGTCTGCTGCTGATGATCCCCAACATGTACAAGATC TCCGGCGAACTTCTGCCCGGCGTGTTCCACGTCACCGCCCGCGCCATCGCCGCGCACGCC CTGTCCATCTTCGGTGACCACCAGGATATCTACGCCGCGCGCCAGACAGGCTTCGCCATG CTCGCCTCCAGCTCGGTGCAGGAGGCCCACGACATGGCCCTGGTGGCCCACTTGGCGGCC ATCGAGTCCAACGTGCCGTTCATGCACTTCTTCGACGGATTCCGCACCTCGCACGAAATC CAGAAGATCGAGGTCCTGGACTACGCGGACATGGCCTCGCTGGTGAACCAGAAGGCCCTG GCGGAATTCCGCGCCAAGTCCATGAACCCCGAGCACCCCCACGTGCGCGGCACGGCCCAG AACCCCGACATCTACTTCCAGGGTCGCGAGGCAGCCAACCCCTACTACCTCAAGGTGCCC GGCATCGTTGCCGAGTACATGCAGAAGGTCGCCTCCCTCACGGGCCGCAGCTACAAGCTC TTTGACTACGTGGGTGCTCCCGACGCCGAGCGCGTCATCGTGTCCATGGGCTCCTCGTGC GAGACCATCGAGGAGGTCATCAACCACCTCGCGGCCAAGGGCGAAAAGATCGGCCTGATC AAGGTCCGCCTGTACAGGCCCTTCGTAAGCGAGGCCTTCTTCGCTGCTCTGCCCGCTTCG GCCAAGGTCATCACGGTCCTCGACCGCACCAAGGAACCCGGCGCGCCCGGCGATCCGCTC TACCTCGACGTGTGCTCGGCCTTCGTGGAGCGCGGCGAAGCCATGCCCAAGATCCTGGCC GGCCGCTACGGCCTGGGTTCCAAGGAATTCAGCCCGGCCATGGTCAAGTCCGTGTACGAC AACATGTCCGGCGCTAAGAAGAACCACTTCACCGTGGGCATCGAAGACGACGTGACCGGC ACTTCGCTGCCGGTGGACAACGCCTTCGCCGACACCACGCCCAAGGGCACCATCCAGTGC CAGTTCTGGGGCCTCGGCGCCGACGGCACTGTGGGCGCCAACAAGCAGGCCATCAAGATC ATCGGCGACAACACGGACCTGTTTGCCCAGGGTTACTTCTCCTACGACTCCAAGAAATCG GGCGGCATCACCATCTCGCACCTGCGCTTCGGCGAGAAGCCCATCCAGTCCACCTACCTG GTCAACAGGGCCGACTATGTCGCCTGTCACAACCCGGCCTACGTGGGCATATACGACATC CTCGAAGGCATCAAGGATGGCGGAACCTTCGTGCTCAACTCGCCTTGGAGCAGCCTCGAG GACATGGACAAGCACCTGCCCTCCGGCATCAAGCGCACCATCGCGAACAAGAAGCTCAAG TTCTACAACATCGACGCGGTGAAAATCGCCACCGATGTGGGACTGGGCGGCCGCATCAAC ATGATCATGCAGACGGCCTTCTTCAAGCTGGCCGGAGTGCTGCCCTTCGAAAAGGCCGTG GATCTGCTCAAGAAGTCCATCCACAAGGCCTACGGCAAAAAGGGCGAGAAGATCGTCAAG ATGAACACCGACGCCGTGGACCAGGCCGTCACCTCCCTGCAGGAATTCAAGTATCCGGAT TCCTGGAAGGACGCTCCCGCTGAGACCAAGGCCGAGCCCATGACGAACGAGTTCTTCAAG AACGTCGTCAAGCCCATCCTGACCCAGCAGGGCGACAAGCTGCCGGTGAGCGCCTTCGAG GCCGACGGCCGTTTCCCCCTCGGCACCAGCCAGTTCGAGAAGCGCGGCGTGGCCATCAAC GTGCCGCAGTGGGTCCCCGAGAACTGCATCCAGTGCAACCAGTGCGCCTTCGTCTGTCCG CACAGCGCCATCCTGCCCGTGCTGGCCAAGGAAGAGGAGTTGGTCGGCGCGCCGGCGAAC TTCACGGCCCTGGAAGCCAAGGGCAAGGAGCTCAAGGGCTACAAGTTCCGCATCCAGATC AACACCCTGGACTGCATGGGCTGCGGCAACTGCGCCGACATCTGTCCGCCCAAGGAAAAG GCTCTGGTCATGCAGCCCCTGGATACCCAGCGCGACGCGCAGGTGCCCAACCTGGAGTAC GCAGCGCGCATCCCGGTCAAATCCGAGGTGCTGCCGCGCGACTCGCTCAAGGGCAGCCAG TTCCAGGAGCCTCTCATGGAATTCTCGGGCGCCTGCTCGGGCTGCGGCGAGACGCCCTAC GTGCGCGTCATCACCCAGCTCTTCGGCGAGCGCATGTTCATTGCCAACGCCACGGGTTGC TCGTCCATCTGGGGCGCGTCGGCTCCTTCCATGCCTTACAAGACCAACCGCCTCGGACAA GGCCCGGCCTGGGGTAACTCCCTGTTCGAAGACGCGGCCGAATACGGCTTCGGCATGAAC ATGTCCATGTTCGCCCGCCGCACGCATTTGGCCGATCTTGCCGCCAAGGCCCTGGAGAGC GATGCCTCCGGCGATGTCAAGGAAGCCCTGCAGGGCTGGCTTGCCGGCAAGAACGATCCC ATCAAGTCCAAGGAATACGGCGACAAGCTCAAGAAGCTGCTGGCTGGTCAGAAGGATGGT CTGCTCGGACAGATCGCCGCCATGTCCGACCTGTACACCAAGAAGAGCGTGTGGATCTTC GGTGGCGACGGCTGGGCCTACGACATCGGTTACGGCGGCCTGGACCATGTGCTCGCCTCG GGCGAGGACGTGAACGTCTTCGTCATGGATACCGAGGTCTACTCCAACACCGGCGGCCAG TCCTCCAAGGCAACGCCCACGGGCGCCGTGGCCAAGTTCGCGGCGGCCGGCAAGCGTACC GGCAAGAAGGACCTGGCGCGCATGGTCATGACCTACGGCTACGTCTACGTGGCTACGGTC TCCATGGGTTACAGCAAGCAGCAGTTCCTCAAGGTGCTCAAGGAAGCCGAAAGCTTCCCC GGCCCCTCGCTGGTCATCGCCTATGCTACCTGCATCAACCAGGGTCTGCGCAAGGGCATG GGCAAGAGCCAGGACGTCATGAACACCGCGGTCAAGTCCGGTTACTGGCCGCTGTTCCGC TACGATCCGCGCTTGGCCGCCCAGGGCAAGAACCCCTTCCAGCTCGACTCCAAGGCTCCT GACGGTTCCGTCGAGGAGTTCCTGATGGCCCAGAACCGCTTCGCCGTCCTCGATCGGTCC TTCCCCGAGGACGCCAAGAGACTGCGCGCCCAGGTCGCTCACGAATTGGACGTGCGTTTC AAGGAGTTGGAGCACATGGCCGCCACGAACATCTTCGAGTCCTTCGCGCCAGCGGGCGGC AAGGCCGATGGTTCGGTGGATTTCGGCGAAGGTGCGGAGTTCTGCACGCGCGACGATACT CCCATGATGGCCCGACCTGATTCCGGTGAGGCCTGCGACCAGAACCGCGCTGGCACGAGC GAACAGCAGGGAGACCTCAGCAAGCGGACGAAGAAGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P94692 UniProtKB Entry Name POR_DESAF GenBank Gene ID Y09702 - General References
- Pieulle L, Magro V, Hatchikian EC: Isolation and analysis of the gene encoding the pyruvate-ferredoxin oxidoreductase of Desulfovibrio africanus, production of the recombinant enzyme in Escherichia coli, and effect of carboxy-terminal deletions on its stability. J Bacteriol. 1997 Sep;179(18):5684-92. [Article]
- Pieulle L, Guigliarelli B, Asso M, Dole F, Bernadac A, Hatchikian EC: Isolation and characterization of the pyruvate-ferredoxin oxidoreductase from the sulfate-reducing bacterium Desulfovibrio africanus. Biochim Biophys Acta. 1995 Jul 3;1250(1):49-59. [Article]
- Chabriere E, Charon MH, Volbeda A, Pieulle L, Hatchikian EC, Fontecilla-Camps JC: Crystal structures of the key anaerobic enzyme pyruvate:ferredoxin oxidoreductase, free and in complex with pyruvate. Nat Struct Biol. 1999 Feb;6(2):182-90. [Article]
- Chabriere E, Vernede X, Guigliarelli B, Charon MH, Hatchikian EC, Fontecilla-Camps JC: Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase. Science. 2001 Dec 21;294(5551):2559-63. [Article]
- Cavazza C, Contreras-Martel C, Pieulle L, Chabriere E, Hatchikian EC, Fontecilla-Camps JC: Flexibility of thiamine diphosphate revealed by kinetic crystallographic studies of the reaction of pyruvate-ferredoxin oxidoreductase with pyruvate. Structure. 2006 Feb;14(2):217-24. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01987 Cocarboxylase approved, experimental unknown Details DB02410 2-Acetyl-3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-4-Methyl-5-(4,6,6-Trihydroxy-3,5-Dioxa-4,6-Diphosphahex-1-Yl)Thiazolium Inner Salt P,P'-Dioxide experimental unknown Details DB00507 Nitazoxanide approved, investigational, vet_approved yes antagonistinhibitor Details