dTDP-glucose 4,6-dehydratase
Details
- Name
- dTDP-glucose 4,6-dehydratase
- Synonyms
- 4.2.1.46
- Gene Name
- rmlB
- Organism
- Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
- Amino acid sequence
>lcl|BSEQ0016843|dTDP-glucose 4,6-dehydratase MTEYKNIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNRANLEEILGDRVELVV GDIADSELVDKLAAKADAIVHYAAESHNDNSLKDPSPFIYTNFVGTYILLEAARKYDIRF HHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWVRSFG VKATISNCSNNYGPYQHIEKFIPRQITNILSGIKPKLYGEGKNVRDWIHTNDHSTGVWAI LTKGRIGETYLIGADGEKNNKEVLELILEKMSQPKNAYDHVTDRAGHDLRYAIDSTKLRE ELGWKPQFTNFEEGLEDTIKWYTEHEDWWKAEKEAVEANYAKTQKILN
- Number of residues
- 348
- Molecular Weight
- 39280.625
- Theoretical pI
- 5.73
- GO Classification
- FunctionsdTDP-glucose 4,6-dehydratase activityProcessesdTDP-rhamnose biosynthetic process / extracellular polysaccharide biosynthetic process / lipopolysaccharide biosynthetic process
- General Function
- Dtdp-glucose 4,6-dehydratase activity
- Specific Function
- Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction.
- Pfam Domain Function
- GDP_Man_Dehyd (PF16363)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016844|dTDP-glucose 4,6-dehydratase (rmlB) ATGACAGAATATAAAAACATTATCGTTACCGGTGGCGCTGGTTTCATCGGTTCAAACTTT GTCCACTACGTTTACAATAATCACCCAGATGTCCATGTGACTGTTCTTGACAAACTCACT TACGCTGGTAACCGTGCTAACCTTGAAGAAATTCTTGGCGACCGTGTAGAGTTGGTTGTT GGGGACATCGCAGACAGCGAATTGGTAGATAAATTGGCTGCCAAAGCGGATGCTATTGTC CACTATGCGGCTGAAAGCCACAATGACAATTCACTAAAAGATCCATCACCATTTATTTAC ACTAACTTTGTTGGAACTTATATCTTGTTGGAAGCTGCACGCAAATACGACATCCGTTTC CACCACGTCTCAACTGATGAAGTTTACGGTGATCTTCCGCTACGTGAAGATTTGCCGGGC CACGGTGAAGGTCCAGGTGAAAAATTCACAGCTGAAACGAAATACAATCCATCATCGCCT TATTCATCAACCAAGGCAGCCTCTGACTTGATTGTCAAGGCTTGGGTGCGATCTTTTGGT GTGAAAGCAACCATTTCCAACTGTTCAAACAACTATGGACCTTACCAACACATCGAAAAA TTCATTCCGCGCCAAATTACTAACATCCTGTCAGGTATCAAACCAAAACTCTATGGTGAA GGTAAGAACGTGCGTGACTGGATTCACACCAATGACCATTCAACAGGAGTTTGGGCAATT CTCACTAAAGGCCGCATCGGCGAAACTTATCTCATCGGTGCTGATGGTGAAAAGAACAAC AAAGAAGTGCTCGAACTTATCCTTGAAAAAATGAGTCAGCCAAAAAATGCATACGACCAT GTAACAGACCGTGCAGGTCATGATCTTCGTTATGCCATTGATTCGACAAAGCTGCGTGAA GAGCTTGGCTGGAAACCACAATTCACTAATTTTGAAGAAGGCTTGGAAGATACCATTAAA TGGTATACTGAGCATGAAGATTGGTGGAAAGCTGAAAAGGAAGCAGTCGAAGCCAACTAT GCCAAAACACAAAAAATACTTAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P95780 UniProtKB Entry Name RMLB_STRMU GenBank Gene ID D78182 - General References
- Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ: Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. Epub 2002 Oct 23. [Article]
- Allard ST, Beis K, Giraud MF, Hegeman AD, Gross JW, Wilmouth RC, Whitfield C, Graninger M, Messner P, Allen AG, Maskell DJ, Naismith JH: Toward a structural understanding of the dehydratase mechanism. Structure. 2002 Jan;10(1):81-92. [Article]