Cytochrome c oxidase subunit 1-beta
Details
- Name
- Cytochrome c oxidase subunit 1-beta
- Synonyms
- 1.9.3.1
- Cytochrome aa3 subunit 1-beta
- Cytochrome c oxidase polypeptide I-beta
- Gene Name
- ctaDII
- Organism
- Paracoccus denitrificans
- Amino acid sequence
>lcl|BSEQ0017350|Cytochrome c oxidase subunit 1-beta MADAAVHGHGDHHDTRGFFTRWFMSTNHKDIGILYLFTAGIVGLISVCFTVYMRMELQHP GVQYMCLEGARLIADASAECTPNGHLWNVMITYHGVLMMFFVVIPALFGGFGNYFMPLHI GAPDMAFPRLNNLSYWMYVCGVALGVASLLAPGGNDQMGSGVGWVLYPPLSTTEAGYSMD LAIFAVHVSGASSILGAINIITTFLNMRAPGMTLFKVPLFAWSVFITAWLILLSLPVLAG AITMLLMDRNFGTQFFDPAGGGDPVLYQHILWFFGHPEVYIIILPGFGIISHVISTFAKK PIFGYLPMVLAMAAIGILGFVVWAHHMYTAGMSLTQQAYFMLATMTIAVPTGIKVFSWIA TMWGGSIEFKTPMLWAFGFLFLFTVGGVTGVVLSQAPLDRVYHDTYYVVAHFHYVMSLGA VFGIFAGVYYWIGKMSGRQYPEWAGQLHFWMMFIGSNLIFFPQHFLGRQGMPRRYIDYPV EFAYWNNISSIGAYISFASFLFFIGIVFYTLFAGKRVNVPNYWNEHADTLEWTLPSPPPE HTFETLPKREDWDRAHAH
- Number of residues
- 558
- Molecular Weight
- 62438.635
- Theoretical pI
- 6.97
- GO Classification
- Functionscopper ion binding / cytochrome-c oxidase activity / heme binding / iron ion bindingProcessesaerobic respiration / electron transport chain / oxidative phosphorylationComponentsintegral component of membrane / plasma membrane / respiratory chain
- General Function
- Iron ion binding
- Specific Function
- Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
- Pfam Domain Function
- COX1 (PF00115)
- Transmembrane Regions
- 29-59 83-120 127-151 177-206 218-251 263-299 304-331 333-364 370-395 405-437 441-469 479-514
- Cellular Location
- Cell inner membrane
- Gene sequence
>lcl|BSEQ0007919|468 bp ATGAAGATCAGCATCTATGCCACTCTCGCCGCCATCACCCTCGCCCTGCCCGCTGCGGCC CAGGATGGCGACGCCGCCAAAGGCGAGAAAGAATTCAACAAGTGCAAGGCTTGCCACATG ATCCAGGCGCCGGACGGCACCGACATCATCAAGGGCGGCAAGACCGGGCCCAACCTTTAC GGCGTCGTCGGCCGCAAGATCGCCTCGGAGGAGGGCTTCAAATACGGCGAAGGCATCCTC GAGGTCGCCGAAAAGAACCCCGACCTGACCTGGACCGAGGCCGACCTGATCGAATACGTC ACCGACCCCAAGCCCTGGCTGGTCAAGATGACCGACGACAAGGGCGCCAAGACCAAGATG ACCTTCAAGATGGGCAAGAACCAGGCCGACGTGGTGGCCTTCCTGGCCCAGAACTCGCCC GATGCGGGCGGCGACGGCGAGGCTGCGGCCGAGGGCGAATCGAACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P98002 UniProtKB Entry Name COX1B_PARDE GenBank Protein ID 45478 GenBank Gene ID Y07533 - General References
- Raitio M, Pispa JM, Metso T, Saraste M: Are there isoenzymes of cytochrome c oxidase in Paracoccus denitrificans? FEBS Lett. 1990 Feb 26;261(2):431-5. [Article]
- Iwata S, Ostermeier C, Ludwig B, Michel H: Structure at 2.8 A resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature. 1995 Aug 24;376(6542):660-9. [Article]
- Ostermeier C, Harrenga A, Ermler U, Michel H: Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10547-53. [Article]
- Buse G, Soulimane T, Dewor M, Meyer HE, Bluggel M: Evidence for a copper-coordinated histidine-tyrosine cross-link in the active site of cytochrome oxidase. Protein Sci. 1999 May;8(5):985-90. [Article]
- Ostermeier C, Iwata S, Michel H: Cytochrome c oxidase. Curr Opin Struct Biol. 1996 Aug;6(4):460-6. [Article]