Adenosylhomocysteinase

Details

Name
Adenosylhomocysteinase
Synonyms
  • 3.3.1.1
  • AdoHcyase
  • S-adenosyl-L-homocysteine hydrolase
  • sahH
Gene Name
ahcY
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051221|Adenosylhomocysteinase
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLK
GARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGV
PVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAE
EDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAI
NVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGAR
VSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGN
IGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFV
MSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL
GVDVEGPYKPDHYRY
Number of residues
495
Molecular Weight
54323.25
Theoretical pI
Not Available
GO Classification
Functions
adenosylhomocysteinase activity / NAD+ binding / zymogen binding
Processes
adenosine metabolic process / adhesion of symbiont to host cell / entry of bacterium into host cell / growth / methionine catabolic process / one-carbon metabolic process / S-adenosylhomocysteine catabolic process / S-adenosylmethionine cycle
Components
cell wall / cytosol / extracellular region / plasma membrane
General Function
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Specific Function
Adenosylhomocysteinase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051222|Adenosylhomocysteinase (ahcY)
ATGACCGGAAATTTGGTGACCAAAAATTCGCTGACCCCTGACGTTCGTAACGGCATCGAC
TTTAAGATCGCCGACCTGTCACTAGCGGATTTCGGCCGCAAAGAACTCCGGATCGCCGAG
CACGAGATGCCCGGCCTGATGTCGCTGCGGCGCGAGTATGCCGAGGTGCAACCCCTGAAG
GGGGCCCGGATCTCGGGTTCGCTGCACATGACGGTGCAGACCGCGGTGTTGATCGAAACC
CTCACCGCGCTGGGCGCCGAAGTCCGCTGGGCCTCGTGCAACATCTTCTCCACCCAGGAT
CACGCCGCCGCCGCCGTCGTGGTCGGCCCGCACGGCACCCCCGACGAGCCCAAGGGTGTC
CCGGTGTTCGCGTGGAAGGGCGAGACGCTCGAAGAGTACTGGTGGGCCGCCGAGCAGATG
CTCACCTGGCCGGACCCCGACAAGCCGGCCAACATGATCCTCGATGACGGCGGTGACGCC
ACCATGTTGGTGCTGCGCGGCATGCAGTATGAGAAGGCCGGCGTGGTGCCGCCCGCCGAG
GAGGACGACCCCGCCGAGTGGAAGGTCTTCCTGAACCTGCTACGGACCCGCTTCGAGACC
GACAAGGACAAGTGGACCAAGATAGCCGAGTCGGTCAAGGGCGTCACCGAGGAGACCACC
ACCGGCGTGCTGCGGCTCTACCAATTCGCCGCGGCCGGGGATCTGGCCTTCCCGGCGATC
AACGTCAACGACTCGGTGACCAAGTCCAAATTCGACAACAAGTACGGCACTCGGCACTCC
CTGATCGACGGCATCAACCGCGGCACCGACGCGCTGATCGGCGGTAAGAAGGTCCTCATC
TGCGGCTACGGCGACGTCGGTAAGGGCTGTGCGGAGGCGATGAAGGGCCAGGGAGCGCGG
GTCTCCGTCACCGAGATCGACCCGATCAACGCGCTGCAGGCCATGATGGAGGGCTTCGAC
GTGGTCACCGTCGAGGAGGCCATCGGGGACGCCGACATCGTCGTAACCGCGACCGGCAAC
AAAGACATCATCATGCTCGAGCACATTAAGGCGATGAAGGACCACGCGATCCTGGGAAAT
ATCGGCCACTTCGACAACGAGATCGACATGGCCGGGCTGGAGCGCTCCGGGGCGACACGG
GTCAACGTCAAGCCTCAGGTCGACCTGTGGACCTTTGGCGACACGGGCCGCTCGATCATC
GTGCTGTCCGAGGGGCGGCTGCTGAACCTGGGCAATGCCACCGGGCACCCCTCGTTCGTG
ATGAGCAACAGCTTCGCTAACCAGACGATCGCCCAGATCGAGCTGTGGACCAAGAACGAC
GAGTACGACAACGAGGTGTACCGGCTGCCCAAGCACCTCGACGAGAAGGTGGCTCGAATC
CATGTCGAGGCCCTTGGCGGTCACCTGACCAAGCTGACCAAGGAGCAGGCCGAATACCTC
GGCGTCGACGTCGAGGGTCCCTACAAGCCGGACCACTACCGCTACTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WGV3
UniProtKB Entry NameSAHH_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH: Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] . PLoS One. 2010 Jan 6;5(1):e8589. doi: 10.1371/journal.pone.0008589. [Article]
  3. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  4. Reddy MC, Kuppan G, Shetty ND, Owen JL, Ioerger TR, Sacchettini JC: Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Sci. 2008 Dec;17(12):2134-44. doi: 10.1110/ps.038125.108. Epub 2008 Sep 24. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB070525'-S-ethyl-5'-thioadenosineexperimentalunknownDetails