NAD(P)H dehydrogenase (quinone)

Details

Name
NAD(P)H dehydrogenase (quinone)
Synonyms
  • 1.6.5.2
  • lpdA-2
  • NAD(P)H quinone reductase
  • NAD(P)H: menadione oxidoreductase
  • NADH-menadione reductase
Gene Name
lpdA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051195|NAD(P)H dehydrogenase (quinone)
MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGL
RTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELI
DSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDA
LPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRL
FKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLT
VDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRP
EIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVA
PIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLDCTAAQDAAE
QLALVPHHLPTSN
Number of residues
493
Molecular Weight
51488.44
Theoretical pI
Not Available
GO Classification
Functions
flavin adenine dinucleotide binding / NAD(P)H dehydrogenase (quinone) activity / NADP+ binding / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Processes
cell redox homeostasis / oxidation-reduction process / pathogenesis
Components
cell
General Function
May contribute to virulence by increasing resistance to reactive oxygen intermediates. It can reduce 2,6-dimethyl-1,4-benzoquinone (DMBQ), 5-hydroxy-1,4-naphthaquinone (5-HNQ) and menadione. NADPH is the physiological reductant rather than NADH.
Specific Function
Flavin adenine dinucleotide binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051196|NAD(P)H dehydrogenase (quinone) (lpdA)
GTGGTGACCCGCATCGTGATCCTCGGTGGCGGCCCGGCCGGTTACGAGGCCGCACTGGTG
GCCGCCACCTCACACCCGGAAACAACCCAAGTTACCGTGATTGACTGCGACGGCATCGGC
GGGGCTGCCGTACTGGACGACTGTGTGCCGTCGAAGACGTTCATCGCCTCCACCGGGCTG
CGTACCGAACTGCGCCGAGCGCCGCACCTGGGCTTTCATATCGACTTCGACGACGCCAAG
ATCTCGTTGCCGCAAATCCATGCCCGGGTCAAGACGCTGGCCGCCGCACAGTCGGCCGAC
ATCACCGCCCAGCTGCTCAGCATGGGGGTTCAGGTGATCGCCGGCCGGGGCGAGTTGATC
GACTCCACACCGGGTCTGGCGCGCCATCGCATTAAGGCGACCGCCGCCGACGGCTCCACC
AGTGAGCATGAGGCCGACGTCGTGCTGGTCGCCACCGGCGCCAGCCCGCGGATCCTGCCG
TCGGCCCAGCCGGACGGTGAGCGCATTCTGACCTGGCGGCAGCTCTACGACTTGGACGCG
TTGCCCGACCACCTCATCGTGGTGGGCTCCGGGGTTACCGGTGCTGAGTTCGTGGACGCC
TATACCGAATTGGGGGTGCCGGTCACGGTGGTGGCCAGCCAGGACCACGTGCTGCCGTAT
GAGGACGCTGACGCTGCGCTGGTCCTGGAAGAGTCGTTCGCCGAACGGGGAGTCCGGCTG
TTCAAAAATGCCCGGGCAGCATCGGTCACCCGCACCGGGGCCGGGGTGCTCGTCACGATG
ACCGACGGTCGCACCGTCGAGGGCAGCCACGCCCTGATGACCATCGGGTCGGTGCCCAAC
ACCAGCGGCCTGGGCCTGGAACGGGTCGGCATCCAGCTTGGCCGGGGCAATTACCTGACC
GTGGACCGGGTGTCGCGGACGTTGGCGACCGGCATCTACGCCGCGGGCGACTGCACGGGT
TTGCTGCCCCTGGCGTCGGTCGCCGCAATGCAGGGCCGCATCGCGATGTACCACGCGCTG
GGGGAGGGCGTCAGCCCGATCCGGTTACGCACGGTGGCCGCGACGGTTTTCACCAGGCCC
GAGATCGCCGCGGTCGGGGTGCCGCAATCGGTCATCGACGCCGGTTCGGTGGCCGCCCGG
ACCATCATGCTGCCGTTACGAACCAACGCGCGCGCCAAGATGTCGGAGATGCGTCACGGG
TTCGTCAAGATCTTCTGCCGGCGGTCCACCGGCGTTGTGATCGGCGGCGTGGTGGTGGCG
CCGATCGCATCGGAGCTGATCCTGCCCATCGCCGTAGCCGTTCAGAACCGCATCACCGTC
AACGAGCTGGCCCAGACACTGGCCGTTTACCCATCGTTGTCGGGTTCGATAACCGAGGCG
GCCCGCCGGCTGATGGCGCACGACGATCTGGACTGCACGGCAGCTCAAGACGCGGCTGAA
CAACTAGCCTTGGTGCCACACCACCTACCGACGAGTAACTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WHH7
UniProtKB Entry NameLPDA_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Akhtar P, Srivastava S, Srivastava A, Srivastava M, Srivastava BS, Srivastava R: Rv3303c of Mycobacterium tuberculosis protects tubercle bacilli against oxidative stress in vivo and contributes to virulence in mice. Microbes Infect. 2006 Nov-Dec;8(14-15):2855-62. Epub 2006 Oct 20. [Article]
  3. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  5. Argyrou A, Vetting MW, Blanchard JS: Characterization of a new member of the flavoprotein disulfide reductase family of enzymes from Mycobacterium tuberculosis. J Biol Chem. 2004 Dec 10;279(50):52694-702. Epub 2004 Sep 29. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03147Flavin adenine dinucleotideapprovedunknownDetails