Serine/threonine-protein kinase PknG

Details

Name
Serine/threonine-protein kinase PknG
Synonyms
  • 2.7.11.1
Gene Name
pknG
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051225|Serine/threonine-protein kinase PknG
MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDR
MATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSET
KGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVL
KGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL
KRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRI
NSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVL
KTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRS
TFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTL
DSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVW
YRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTND
GVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQ
IRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEAS
LRSLARVAPTQRHRYTLVDMANKVRPTSTF
Number of residues
750
Molecular Weight
81576.575
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / protein serine/threonine kinase activity
Processes
avoidance of host defenses / glutamate catabolic process / glutamine catabolic process / growth / modulation by symbiont of host phagocytosis / modulation by symbiont of host signal transduction pathway / negative regulation of cytolysis by symbiont of host cells / pathogenesis / positive regulation by symbiont of defense-related host reactive oxygen species production / protein autophosphorylation / response to antibiotic
Components
cytosol / plasma membrane
General Function
Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051226|Serine/threonine-protein kinase PknG (pknG)
ATGGCCAAAGCGTCAGAGACCGAACGTTCGGGCCCCGGCACCCAACCGGCGGACGCCCAG
ACCGCGACGTCCGCGACGGTTCGACCCCTGAGCACCCAGGCGGTGTTCCGCCCCGATTTC
GGCGATGAGGACAACTTCCCCCATCCGACGCTCGGCCCGGACACCGAGCCGCAAGACCGG
ATGGCCACCACCAGCCGGGTGCGCCCGCCGGTCAGACGGCTGGGCGGCGGCCTGGTGGAA
ATCCCGCGGGCGCCCGATATCGATCCGCTTGAGGCCCTGATGACCAACCCGGTGGTGCCG
GAGTCCAAGCGGTTCTGCTGGAACTGTGGACGTCCCGTCGGCCGGTCCGACTCGGAGACC
AAGGGAGCTTCAGAGGGCTGGTGTCCCTATTGCGGCAGCCCGTATTCGTTCCTGCCGCAG
CTAAATCCCGGGGACATCGTCGCCGGCCAGTACGAGGTCAAAGGCTGCATCGCGCACGGC
GGACTGGGCTGGATCTACCTCGCTCTCGACCGCAATGTCAACGGCCGTCCGGTGGTGCTC
AAGGGCCTGGTGCATTCCGGTGATGCCGAAGCGCAGGCAATGGCGATGGCCGAACGCCAG
TTCCTGGCCGAGGTGGTGCACCCGTCGATCGTGCAGATCTTCAACTTTGTCGAGCACACC
GACAGGCACGGGGATCCGGTCGGCTACATCGTGATGGAATACGTCGGCGGGCAATCGCTC
AAACGCAGCAAGGGTCAGAAACTGCCCGTCGCGGAGGCCATCGCCTACCTGCTGGAGATC
CTGCCGGCGCTGAGCTACCTGCATTCCATCGGCTTGGTCTACAACGACCTGAAGCCGGAA
AACATCATGCTGACCGAGGAACAGCTCAAGCTGATCGACCTGGGCGCGGTATCGCGGATC
AACTCGTTCGGCTACCTCTACGGGACCCCAGGCTTCCAGGCGCCCGAGATCGTGCGGACC
GGTCCGACGGTGGCCACCGACATCTACACCGTGGGACGCACGCTCGCGGCGCTCACGCTG
GACCTGCCCACCCGCAATGGCCGTTATGTGGATGGGCTACCCGAAGACGACCCGGTGCTG
AAAACCTACGACTCTTACGGCCGGTTGCTGCGCAGGGCCATCGACCCCGATCCGCGGCAA
CGGTTCACCACCGCCGAAGAGATGTCCGCGCAATTGACGGGCGTGTTGCGGGAGGTGGTC
GCCCAGGACACCGGGGTGCCGCGGCCAGGGCTATCAACGATCTTCAGTCCCAGTCGGTCG
ACATTTGGAGTGGACCTGCTGGTGGCGCACACCGACGTGTATCTGGACGGGCAGGTGCAC
GCGGAGAAGCTGACCGCCAACGAGATCGTGACCGCGCTGTCGGTGCCGCTGGTCGATCCG
ACCGACGTCGCAGCTTCGGTCCTGCAGGCCACGGTGCTCTCCCAGCCGGTGCAGACCCTA
GACTCGCTGCGCGCGGCCCGCCACGGTGCGCTGGACGCCGACGGCGTCGACTTCTCCGAG
TCAGTGGAGCTGCCGCTAATGGAAGTCCGCGCGCTGCTGGATCTCGGCGATGTGGCCAAG
GCCACCCGAAAACTCGACGATCTGGCCGAACGCGTTGGCTGGCGATGGCGATTGGTCTGG
TACCGGGCCGTCGCCGAGCTGCTCACCGGCGACTATGACTCGGCCACCAAACATTTCACC
GAGGTGCTGGATACCTTTCCCGGCGAGCTGGCGCCCAAGCTCGCCCTGGCCGCCACCGCC
GAACTAGCCGGCAACACCGACGAACACAAGTTCTATCAGACGGTGTGGAGCACCAACGAC
GGCGTGATCTCGGCGGCTTTCGGACTGGCCAGAGCCCGGTCGGCCGAAGGTGATCGGGTC
GGCGCCGTGCGCACGCTCGACGAGGTACCGCCCACTTCTCGGCATTTCACCACGGCACGG
CTGACCAGCGCGGTGACTCTGTTGTCCGGCCGGTCAACGAGTGAAGTCACCGAGGAACAG
ATCCGCGACGCCGCCCGAAGAGTGGAGGCGCTGCCCCCGACCGAACCACGCGTGCTGCAG
ATCCGCGCCCTGGTGCTGGGTGGCGCGCTGGACTGGCTGAAGGACAACAAGGCCAGCACC
AACCACATCCTCGGTTTCCCGTTCACCAGTCACGGGCTGCGGCTGGGTGTCGAGGCGTCA
CTGCGCAGCCTGGCCCGGGTAGCTCCCACTCAACGGCATCGCTACACGCTGGTGGACATG
GCCAACAAGGTCCGGCCCACCAGCACGTTCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WI73
UniProtKB Entry NamePKNG_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Cowley S, Ko M, Pick N, Chow R, Downing KJ, Gordhan BG, Betts JC, Mizrahi V, Smith DA, Stokes RW, Av-Gay Y: The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo. Mol Microbiol. 2004 Jun;52(6):1691-702. [Article]
  3. Koul A, Choidas A, Tyagi AK, Drlica K, Singh Y, Ullrich A: Serine/threonine protein kinases PknF and PknG of Mycobacterium tuberculosis: characterization and localization. Microbiology. 2001 Aug;147(Pt 8):2307-14. [Article]
  4. O'Hare HM, Duran R, Cervenansky C, Bellinzoni M, Wehenkel AM, Pritsch O, Obal G, Baumgartner J, Vialaret J, Johnsson K, Alzari PM: Regulation of glutamate metabolism by protein kinases in mycobacteria. Mol Microbiol. 2008 Dec;70(6):1408-23. doi: 10.1111/j.1365-2958.2008.06489.x. Epub 2008 Oct 17. [Article]
  5. Wolff KA, Nguyen HT, Cartabuke RH, Singh A, Ogwang S, Nguyen L: Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria. Antimicrob Agents Chemother. 2009 Aug;53(8):3515-9. doi: 10.1128/AAC.00012-09. Epub 2009 Jun 15. [Article]
  6. Tiwari D, Singh RK, Goswami K, Verma SK, Prakash B, Nandicoori VK: Key residues in Mycobacterium tuberculosis protein kinase G play a role in regulating kinase activity and survival in the host. J Biol Chem. 2009 Oct 2;284(40):27467-79. doi: 10.1074/jbc.M109.036095. Epub 2009 Jul 28. [Article]
  7. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  8. Scherr N, Honnappa S, Kunz G, Mueller P, Jayachandran R, Winkler F, Pieters J, Steinmetz MO: Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12151-6. Epub 2007 Jul 6. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB073982-[(CYCLOPROPYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDEexperimentalunknownDetails