Serine/threonine-protein kinase PknG
Details
- Name
- Serine/threonine-protein kinase PknG
- Synonyms
- 2.7.11.1
- Gene Name
- pknG
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051225|Serine/threonine-protein kinase PknG MAKASETERSGPGTQPADAQTATSATVRPLSTQAVFRPDFGDEDNFPHPTLGPDTEPQDR MATTSRVRPPVRRLGGGLVEIPRAPDIDPLEALMTNPVVPESKRFCWNCGRPVGRSDSET KGASEGWCPYCGSPYSFLPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVL KGLVHSGDAEAQAMAMAERQFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL KRSKGQKLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEEQLKLIDLGAVSRI NSFGYLYGTPGFQAPEIVRTGPTVATDIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVL KTYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRS TFGVDLLVAHTDVYLDGQVHAEKLTANEIVTALSVPLVDPTDVAASVLQATVLSQPVQTL DSLRAARHGALDADGVDFSESVELPLMEVRALLDLGDVAKATRKLDDLAERVGWRWRLVW YRAVAELLTGDYDSATKHFTEVLDTFPGELAPKLALAATAELAGNTDEHKFYQTVWSTND GVISAAFGLARARSAEGDRVGAVRTLDEVPPTSRHFTTARLTSAVTLLSGRSTSEVTEEQ IRDAARRVEALPPTEPRVLQIRALVLGGALDWLKDNKASTNHILGFPFTSHGLRLGVEAS LRSLARVAPTQRHRYTLVDMANKVRPTSTF
- Number of residues
- 750
- Molecular Weight
- 81576.575
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / protein serine/threonine kinase activityProcessesavoidance of host defenses / glutamate catabolic process / glutamine catabolic process / growth / modulation by symbiont of host phagocytosis / modulation by symbiont of host signal transduction pathway / negative regulation of cytolysis by symbiont of host cells / pathogenesis / positive regulation by symbiont of defense-related host reactive oxygen species production / protein autophosphorylation / response to antibioticComponentscytosol / plasma membrane
- General Function
- Phosphorylates GarA. May play a role in metabolic regulation via control of the phosphorylation status of GarA. Plays a crucial role in the survival of mycobacteria within host macrophages, by blocking the intracellular degradation of mycobacteria in lysosomes. Required for intrinsic antibiotic resistance.
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051226|Serine/threonine-protein kinase PknG (pknG) ATGGCCAAAGCGTCAGAGACCGAACGTTCGGGCCCCGGCACCCAACCGGCGGACGCCCAG ACCGCGACGTCCGCGACGGTTCGACCCCTGAGCACCCAGGCGGTGTTCCGCCCCGATTTC GGCGATGAGGACAACTTCCCCCATCCGACGCTCGGCCCGGACACCGAGCCGCAAGACCGG ATGGCCACCACCAGCCGGGTGCGCCCGCCGGTCAGACGGCTGGGCGGCGGCCTGGTGGAA ATCCCGCGGGCGCCCGATATCGATCCGCTTGAGGCCCTGATGACCAACCCGGTGGTGCCG GAGTCCAAGCGGTTCTGCTGGAACTGTGGACGTCCCGTCGGCCGGTCCGACTCGGAGACC AAGGGAGCTTCAGAGGGCTGGTGTCCCTATTGCGGCAGCCCGTATTCGTTCCTGCCGCAG CTAAATCCCGGGGACATCGTCGCCGGCCAGTACGAGGTCAAAGGCTGCATCGCGCACGGC GGACTGGGCTGGATCTACCTCGCTCTCGACCGCAATGTCAACGGCCGTCCGGTGGTGCTC AAGGGCCTGGTGCATTCCGGTGATGCCGAAGCGCAGGCAATGGCGATGGCCGAACGCCAG TTCCTGGCCGAGGTGGTGCACCCGTCGATCGTGCAGATCTTCAACTTTGTCGAGCACACC GACAGGCACGGGGATCCGGTCGGCTACATCGTGATGGAATACGTCGGCGGGCAATCGCTC AAACGCAGCAAGGGTCAGAAACTGCCCGTCGCGGAGGCCATCGCCTACCTGCTGGAGATC CTGCCGGCGCTGAGCTACCTGCATTCCATCGGCTTGGTCTACAACGACCTGAAGCCGGAA AACATCATGCTGACCGAGGAACAGCTCAAGCTGATCGACCTGGGCGCGGTATCGCGGATC AACTCGTTCGGCTACCTCTACGGGACCCCAGGCTTCCAGGCGCCCGAGATCGTGCGGACC GGTCCGACGGTGGCCACCGACATCTACACCGTGGGACGCACGCTCGCGGCGCTCACGCTG GACCTGCCCACCCGCAATGGCCGTTATGTGGATGGGCTACCCGAAGACGACCCGGTGCTG AAAACCTACGACTCTTACGGCCGGTTGCTGCGCAGGGCCATCGACCCCGATCCGCGGCAA CGGTTCACCACCGCCGAAGAGATGTCCGCGCAATTGACGGGCGTGTTGCGGGAGGTGGTC GCCCAGGACACCGGGGTGCCGCGGCCAGGGCTATCAACGATCTTCAGTCCCAGTCGGTCG ACATTTGGAGTGGACCTGCTGGTGGCGCACACCGACGTGTATCTGGACGGGCAGGTGCAC GCGGAGAAGCTGACCGCCAACGAGATCGTGACCGCGCTGTCGGTGCCGCTGGTCGATCCG ACCGACGTCGCAGCTTCGGTCCTGCAGGCCACGGTGCTCTCCCAGCCGGTGCAGACCCTA GACTCGCTGCGCGCGGCCCGCCACGGTGCGCTGGACGCCGACGGCGTCGACTTCTCCGAG TCAGTGGAGCTGCCGCTAATGGAAGTCCGCGCGCTGCTGGATCTCGGCGATGTGGCCAAG GCCACCCGAAAACTCGACGATCTGGCCGAACGCGTTGGCTGGCGATGGCGATTGGTCTGG TACCGGGCCGTCGCCGAGCTGCTCACCGGCGACTATGACTCGGCCACCAAACATTTCACC GAGGTGCTGGATACCTTTCCCGGCGAGCTGGCGCCCAAGCTCGCCCTGGCCGCCACCGCC GAACTAGCCGGCAACACCGACGAACACAAGTTCTATCAGACGGTGTGGAGCACCAACGAC GGCGTGATCTCGGCGGCTTTCGGACTGGCCAGAGCCCGGTCGGCCGAAGGTGATCGGGTC GGCGCCGTGCGCACGCTCGACGAGGTACCGCCCACTTCTCGGCATTTCACCACGGCACGG CTGACCAGCGCGGTGACTCTGTTGTCCGGCCGGTCAACGAGTGAAGTCACCGAGGAACAG ATCCGCGACGCCGCCCGAAGAGTGGAGGCGCTGCCCCCGACCGAACCACGCGTGCTGCAG ATCCGCGCCCTGGTGCTGGGTGGCGCGCTGGACTGGCTGAAGGACAACAAGGCCAGCACC AACCACATCCTCGGTTTCCCGTTCACCAGTCACGGGCTGCGGCTGGGTGTCGAGGCGTCA CTGCGCAGCCTGGCCCGGGTAGCTCCCACTCAACGGCATCGCTACACGCTGGTGGACATG GCCAACAAGGTCCGGCCCACCAGCACGTTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WI73 UniProtKB Entry Name PKNG_MYCTU - General References
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