Peptide deformylase
Details
- Name
- Peptide deformylase
- Synonyms
- 3.5.1.88
- Polypeptide deformylase
- Gene Name
- def
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051268|Peptide deformylase MAVVPIRIVGDPVLHTATTPVTVAADGSLPADLAQLIATMYDTMDAANGVGLAANQIGCS LRLFVYDCAADRAMTARRRGVVINPVLETSEIPETMPDPDTDDEGCLSVPGESFPTGRAK WARVTGLDADGSPVSIEGTGLFARMLQHETGHLDGFLYLDRLIGRYARNAKRAVKSHGWG VPGLSWLPGEDPDPFGH
- Number of residues
- 197
- Molecular Weight
- 20938.52
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetal ion binding / peptide deformylase activityProcessesco-translational protein modification / growth / N-terminal protein amino acid modification / peptidyl-methionine modification / protein deacylation / translation
- General Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
- Specific Function
- Metal ion binding
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051269|Peptide deformylase (def) ATGGCAGTCGTACCCATCCGCATCGTGGGCGATCCCGTCTTACACACTGCGACCACACCG GTGACGGTCGCCGCCGACGGTTCACTCCCGGCGGATCTCGCCCAGTTGATCGCCACCATG TACGACACCATGGACGCCGCCAACGGAGTCGGCCTGGCTGCCAACCAGATCGGCTGCAGC CTGCGGCTCTTCGTCTACGATTGCGCCGCGGACCGCGCAATGACCGCCCGCCGACGCGGT GTGGTCATCAATCCGGTGCTTGAGACCTCCGAAATACCTGAGACCATGCCCGACCCGGAC ACCGACGACGAAGGCTGTCTGTCGGTTCCCGGCGAGTCATTTCCTACCGGACGCGCGAAG TGGGCACGAGTCACCGGACTCGACGCCGATGGCAGTCCGGTCAGTATCGAGGGCACCGGC CTGTTCGCGCGGATGCTGCAGCACGAAACCGGGCACCTTGATGGATTCCTGTACCTGGAC CGCCTCATCGGCCGGTACGCCCGCAACGCCAAACGGGCCGTCAAGTCACATGGCTGGGGC GTTCCCGGACTGTCGTGGCTGCCCGGCGAGGACCCCGACCCGTTCGGTCACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WIJ3 UniProtKB Entry Name DEF_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]