UDP-galactopyranose mutase
Details
- Name
- UDP-galactopyranose mutase
- Synonyms
- 5.4.99.9
- UDP-GALP mutase
- UGM
- Uridine 5-diphosphate galactopyranose mutase
- Gene Name
- glf
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051197|UDP-galactopyranose mutase MQPMTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVH KYGAHLFHTSNKRVWDYVRQFTDFTDYRHRVFAMHNGQAYQFPMGLGLVSQFFGKYFTPE QARQLIAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKELPAANITR LPVRYTFDNRYFSDTYEGLPTDGYTAWLQNMAADHRIEVRLNTDWFDVRGQLRPGSPAAP VVYTGPLDRYFDYAEGRLGWRTLDFEVEVLPIGDFQGTAVMNYNDLDVPYTRIHEFRHFH PERDYPTDKTVIMREYSRFAEDDDEPYYPINTEADRALLATYRARAKSETASSKVLFGGR LGTYQYLDMHMAIASALNMYDNVLAPHLRDGVPLLQDGA
- Number of residues
- 399
- Molecular Weight
- 45814.07
- Theoretical pI
- Not Available
- GO Classification
- FunctionsUDP-galactopyranose mutase activityProcessesActinobacterium-type cell wall biogenesis / capsule polysaccharide biosynthetic process / cell wall organizationComponentscell wall / plasma membrane
- General Function
- Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) which is a key building block for cell wall construction in Mycobacterium tuberculosis.
- Specific Function
- Udp-galactopyranose mutase activity
- Pfam Domain Function
- GLF (PF03275)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051198|UDP-galactopyranose mutase (glf) ATGCAACCGATGACCGCTCGTTTTGACCTTTTCGTCGTCGGCTCAGGATTCTTCGGCCTG ACGATTGCCGAGCGCGTGGCCACCCAACTCGACAAGCGCGTGCTCGTCCTCGAGCGGCGC CCGCACATCGGGGGCAATGCCTATTCCGAAGCCGAGCCACAGACCGGCATCGAGGTCCAC AAGTACGGTGCGCACCTGTTTCACACCTCTAATAAGAGAGTGTGGGACTACGTGCGGCAG TTCACCGACTTCACCGACTACCGGCACCGGGTCTTCGCGATGCACAACGGGCAGGCATAT CAGTTTCCGATGGGGCTCGGCCTGGTATCGCAGTTCTTCGGCAAGTACTTCACGCCCGAG CAAGCCCGCCAGCTGATCGCCGAGCAGGCCGCCGAGATCGACACCGCCGACGCGCAGAAC CTCGAGGAGAAGGCCATCTCGCTGATCGGCCGGCCGCTCTACGAAGCGTTCGTCAAGGGG TACACGGCCAAGCAATGGCAGACTGACCCCAAAGAACTTCCGGCCGCCAACATCACGCGG CTTCCCGTGCGCTACACCTTCGACAACCGGTATTTCAGCGATACTTACGAGGGTTTGCCG ACCGACGGGTACACGGCGTGGTTGCAAAACATGGCCGCTGACCACCGCATCGAGGTCAGG CTGAACACCGACTGGTTCGACGTGCGCGGCCAGCTGCGCCCCGGCAGCCCGGCGGCCCCG GTCGTTTACACCGGCCCGCTGGACCGCTACTTCGACTACGCCGAAGGCCGATTGGGCTGG CGCACCTTGGACTTCGAGGTGGAAGTGCTACCGATCGGGGACTTTCAGGGCACCGCGGTG ATGAACTACAACGATCTCGACGTCCCCTACACGCGCATCCACGAGTTCCGCCACTTCCAC CCCGAGCGTGACTACCCAACGGACAAAACGGTGATCATGCGGGAATACTCCCGGTTCGCC GAGGACGACGACGAGCCATACTATCCGATCAACACCGAGGCTGACCGCGCCCTGTTGGCC ACCTATCGGGCCAGGGCGAAGTCCGAGACCGCGTCATCGAAGGTACTGTTCGGCGGCCGG TTGGGCACCTACCAATATCTGGATATGCATATGGCCATTGCCAGCGCCTTGAACATGTAC GACAACGTCCTCGCGCCGCATCTGCGCGACGGCGTCCCACTGCTTCAGGACGGCGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WIQ1 UniProtKB Entry Name GLF_MYCTU - General References
- Weston A, Stern RJ, Lee RE, Nassau PM, Monsey D, Martin SL, Scherman MS, Besra GS, Duncan K, McNeil MR: Biosynthetic origin of mycobacterial cell wall galactofuranosyl residues. Tuber Lung Dis. 1997;78(2):123-31. [Article]
- Chen P, Bishai WR: Novel selection for isoniazid (INH) resistance genes supports a role for NAD+-binding proteins in mycobacterial INH resistance. Infect Immun. 1998 Nov;66(11):5099-106. [Article]
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Beis K, Srikannathasan V, Liu H, Fullerton SW, Bamford VA, Sanders DA, Whitfield C, McNeil MR, Naismith JH: Crystal structures of Mycobacteria tuberculosis and Klebsiella pneumoniae UDP-galactopyranose mutase in the oxidised state and Klebsiella pneumoniae UDP-galactopyranose mutase in the (active) reduced state. J Mol Biol. 2005 May 13;348(4):971-82. [Article]