Uncharacterized MFS-type transporter EfpA

Details

Name
Uncharacterized MFS-type transporter EfpA
Synonyms
  • Efflux protein A
Gene Name
efpA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0052073|Uncharacterized MFS-type transporter EfpA
MTALNDTERAVRNWTAGRPHRPAPMRPPRSEETASERPSRYYPTWLPSRSFIAAVIAIGG
MQLLATMDSTVAIVALPKIQNELSLSDAGRSWVITAYVLTFGGLMLLGGRLGDTIGRKRT
FIVGVALFTISSVLCAVAWDEATLVIARLSQGVGSAIASPTGLALVATTFPKGPARNAAT
AVFAAMTAIGSVMGLVVGGALTEVSWRWAFLVNVPIGLVMIYLARTALRETNKERMKLDA
TGAILATLACTAAVFAFSIGPEKGWMSGITIGSGLVALAAAVAFVIVERTAENPVVPFHL
FRDRNRLVTFSAILLAGGVMFSLTVCIGLYVQDILGYSALRAGVGFIPFVIAMGIGLGVS
SQLVSRFSPRVLTIGGGYLLFGAMLYGSFFMHRGVPYFPNLVMPIVVGGIGIGMAVVPLT
LSAIAGVGFDQIGPVSAIALMLQSLGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDVQL
AALDHAYTYGLLWVAGAAIIVGGMALFIGYTPQQVAHAQEVKEAIDAGEL
Number of residues
530
Molecular Weight
55578.955
Theoretical pI
Not Available
GO Classification
Processes
transmembrane transport
Components
integral component of membrane / plasma membrane
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
51-71 92-112 120-140 151-171 181-201 204-224 240-260 267-287 307-327 344-364 371-391 401-421 438-458 489-509
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052074|Uncharacterized MFS-type transporter EfpA (efpA)
ATGACGGCTCTCAACGACACAGAGCGGGCGGTCCGTAACTGGACAGCCGGACGCCCACAC
CGTCCGGCCCCGATGCGCCCGCCGCGCTCGGAGGAGACCGCTTCAGAGCGCCCCAGCAGG
TACTACCCGACTTGGCTGCCCTCGCGCAGCTTTATCGCTGCGGTTATTGCTATCGGCGGG
ATGCAGCTGCTGGCGACCATGGACAGCACCGTCGCCATCGTCGCGCTACCTAAGATTCAA
AACGAGCTGAGCTTGTCTGATGCCGGCCGCAGCTGGGTGATCACCGCCTACGTGCTGACC
TTCGGCGGGCTGATGCTGCTCGGCGGCCGGCTTGGCGACACCATCGGGCGCAAACGCACC
TTCATTGTTGGCGTTGCGCTATTCACCATCTCGTCGGTGCTGTGCGCGGTCGCCTGGGAC
GAGGCGACGTTGGTGATCGCCCGGTTGTCCCAGGGTGTGGGGTCGGCCATCGCATCTCCG
ACCGGTCTGGCGCTGGTGGCGACCACGTTCCCCAAGGGACCTGCCCGCAACGCCGCGACG
GCGGTGTTCGCCGCGATGACCGCGATCGGGTCGGTGATGGGGCTGGTGGTCGGCGGAGCA
CTGACCGAGGTGTCATGGCGGTGGGCGTTCCTGGTGAACGTGCCGATCGGGCTGGTGATG
ATCTACCTGGCCCGCACCGCCCTACGGGAAACCAACAAAGAACGGATGAAGCTCGACGCC
ACCGGGGCCATACTGGCCACGCTGGCATGCACCGCGGCGGTTTTCGCCTTCTCGATCGGT
CCTGAAAAGGGCTGGATGTCAGGCATTACCATCGGTTCGGGCCTGGTGGCCTTGGCGGCC
GCTGTCGCGTTTGTCATCGTGGAGCGCACTGCCGAGAACCCCGTCGTGCCGTTCCACTTG
TTCCGCGACCGCAACCGGTTGGTCACGTTCAGCGCGATCCTGTTGGCCGGCGGCGTCATG
TTCAGCCTGACCGTCTGCATCGGCCTGTACGTGCAGGACATCTTGGGCTACAGCGCGCTA
CGCGCGGGCGTAGGTTTCATCCCGTTCGTCATCGCGATGGGAATCGGCCTAGGTGTGTCC
TCGCAGCTGGTGTCCCGGTTTTCGCCACGGGTGTTGACCATCGGCGGCGGATATCTGCTA
TTCGGCGCCATGCTGTACGGCTCATTTTTCATGCACCGTGGTGTGCCCTACTTCCCCAAC
CTGGTCATGCCGATCGTCGTCGGCGGGATTGGCATCGGCATGGCCGTCGTCCCGCTGACT
CTGTCGGCGATCGCTGGCGTCGGCTTCGACCAGATCGGTCCGGTATCGGCAATTGCGCTG
ATGCTGCAGAGCCTGGGCGGTCCGCTGGTGCTCGCCGTCATCCAGGCTGTGATCACGTCG
CGCACGCTGTACCTGGGCGGTACCACCGGTCCGGTGAAGTTCATGAACGACGTGCAGTTG
GCCGCGCTTGACCACGCCTACACCTACGGCCTGCTGTGGGTGGCCGGAGCGGCCATCATC
GTCGGCGGTATGGCGCTGTTTATCGGGTATACGCCGCAGCAGGTTGCCCATGCGCAGGAG
GTCAAGGAAGCGATCGACGCCGGCGAGCTGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WJY5
UniProtKB Entry NameEFPA_MYCTU
General References
  1. Doran JL, Pang Y, Mdluli KE, Moran AJ, Victor TC, Stokes RW, Mahenthiralingam E, Kreiswirth BN, Butt JL, Baron GS, Treit JD, Kerr VJ, Van Helden PD, Roberts MC, Nano FE: Mycobacterium tuberculosis efpA encodes an efflux protein of the QacA transporter family. Clin Diagn Lab Immunol. 1997 Jan;4(1):23-32. [Article]
  2. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  3. Colangeli R, Helb D, Vilcheze C, Hazbon MH, Lee CG, Safi H, Sayers B, Sardone I, Jones MB, Fleischmann RD, Peterson SN, Jacobs WR Jr, Alland D: Transcriptional regulation of multi-drug tolerance and antibiotic-induced responses by the histone-like protein Lsr2 in M. tuberculosis. PLoS Pathog. 2007 Jun;3(6):e87. doi: 10.1371/journal.ppat.0030087. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05154Pretomanidapprovedunknownother/unknownDetails