Iron-dependent extradiol dioxygenase

Details

Name
Iron-dependent extradiol dioxygenase
Synonyms
  • 1.13.11.25
  • bphC
Gene Name
hsaC
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051272|Iron-dependent extradiol dioxygenase
MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYLRMDDFPARLVVVPGEHDR
LLEAGWECANAEGLQEIRNRLDLEGTPYKEATAAELADRRVDEMIRFADPSGNCLEVFHG
TALEHRRVVSPYGHRFVTGEQGMGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVG
RPADGPPAWLRFFGCNPRHHSLAFLPMPTSSGIVHLMVEVEQADDVGLCLDRALRRKVPM
SATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLWGHDFTVGARG
Number of residues
300
Molecular Weight
33581.985
Theoretical pI
Not Available
GO Classification
Functions
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity / ferrous iron binding / iron ion binding
Processes
aromatic compound catabolic process / cholesterol catabolic process / pathogenesis / response to cholesterol
General Function
Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).
Specific Function
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051273|Iron-dependent extradiol dioxygenase (hsaC)
ATGAGCATCCGGTCGCTGGGCTATCTGCGCATCGAGGCCACTGACATGGCTGCCTGGCGG
GAGTATGGACTGAAGGTCCTGGGCATGGTCGAGGGCAAAGGGGCCCCAGAAGGGGCCCTG
TATCTGCGGATGGATGACTTTCCGGCCCGGCTGGTGGTCGTGCCCGGTGAGCACGACAGG
CTGTTGGAGGCCGGTTGGGAATGCGCGAATGCCGAAGGCCTGCAGGAAATCCGGAACCGC
CTGGATTTGGAGGGCACGCCGTACAAAGAGGCCACCGCCGCCGAGCTGGCCGATCGCCGG
GTGGACGAGATGATCCGGTTTGCCGACCCTTCCGGCAATTGCCTGGAGGTCTTCCACGGT
ACCGCGCTGGAACACCGCCGAGTGGTCAGCCCGTATGGGCACAGGTTCGTCACCGGTGAG
CAGGGTATGGGCCATGTGGTGCTGTCCACCCGCGACGATGCTGAGGCGTTGCATTTCTAC
CGAGACGTGCTCGGCTTTCGGCTGCGTGACTCGATGCGGCTACCGCCACAGATGGTAGGG
CGGCCCGCCGACGGGCCGCCAGCCTGGCTGCGTTTCTTCGGCTGTAACCCGCGTCACCAC
TCGTTGGCCTTCCTGCCGATGCCGACGTCCAGCGGCATCGTGCACCTGATGGTCGAGGTC
GAGCAGGCCGACGACGTGGGCCTGTGCCTGGACCGGGCGTTGCGGCGCAAGGTGCCGATG
TCGGCCACCCTGGGCCGGCATGTCAACGACCTGATGCTGTCGTTCTACATGAAGACGCCC
GGTGGCTTCGACATCGAATTCGGTTGTGAGGGCAGGCAAGTCGACGATCGGGACTGGATC
GCCCGGGAGAGTACTGCGGTCAGCCTATGGGGTCACGATTTCACCGTAGGCGCTCGCGGC
TAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WNW7
UniProtKB Entry NameHSAC_MYCTU
General References
  1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  2. Kendall SL, Withers M, Soffair CN, Moreland NJ, Gurcha S, Sidders B, Frita R, Ten Bokum A, Besra GS, Lott JS, Stoker NG: A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol Microbiol. 2007 Aug;65(3):684-99. [Article]
  3. Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD: A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1947-52. Epub 2007 Jan 30. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  5. Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD: Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. PLoS Pathog. 2009 Mar;5(3):e1000344. doi: 10.1371/journal.ppat.1000344. Epub 2009 Mar 20. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB085423,4-dihydroxy-9,10-secoandrosta-1(10),2,4-triene-9,17-dioneexperimentalunknownDetails