3-dehydroquinate dehydratase

Details

Name
3-dehydroquinate dehydratase
Synonyms
  • 3-dehydroquinase
  • 4.2.1.10
  • aroD
  • Type II DHQase
Gene Name
aroQ
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051126|3-dehydroquinate dehydratase
MSELIVNVINGPNLGRLGRREPAVYGGTTHDELVALIEREAAELGLKAVVRQSDSEAQLL
DWIHQAADAAEPVILNAGGLTHTSVALRDACAELSAPLIEVHISNVHAREEFRRHSYLSP
IATGVIVGLGIQGYLLALRYLAEHVGT
Number of residues
147
Molecular Weight
15789.81
Theoretical pI
Not Available
GO Classification
Functions
3-dehydroquinate dehydratase activity
Processes
aromatic amino acid family biosynthetic process / chorismate biosynthetic process / growth
Components
cytosol
General Function
Catalyzes a trans-dehydration via an enolate intermediate.
Specific Function
3-dehydroquinate dehydratase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051127|3-dehydroquinate dehydratase (aroQ)
ATGAGCGAACTGATCGTGAACGTGATCAACGGCCCCAACCTGGGCCGGTTGGGCCGGCGC
GAGCCCGCCGTCTATGGCGGCACCACCCACGACGAGCTGGTCGCTCTGATCGAGCGTGAG
GCCGCCGAGCTCGGACTCAAAGCCGTTGTGCGGCAAAGTGATAGCGAAGCCCAGCTGCTG
GACTGGATTCATCAGGCCGCCGATGCGGCCGAACCCGTGATCCTCAACGCCGGCGGTCTG
ACGCACACGTCGGTGGCACTGCGCGATGCCTGCGCGGAGCTGAGCGCTCCGCTGATCGAG
GTGCATATCTCCAACGTGCATGCGCGTGAGGAGTTCCGCCGCCACTCCTACCTCAGCCCC
ATCGCGACCGGGGTGATCGTCGGGCTCGGCATCCAGGGCTACCTGCTGGCCCTGCGGTAC
CTAGCTGAGCATGTCGGGACGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WPX7
UniProtKB Entry NameAROQ_MYCTU
General References
  1. Garbe T, Servos S, Hawkins A, Dimitriadis G, Young D, Dougan G, Charles I: The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Mol Gen Genet. 1991 Sep;228(3):385-92. [Article]
  2. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  3. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
  5. Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR, Hawkins AR, Isaacs NW, Sawyer L: The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Nat Struct Biol. 1999 Jun;6(6):521-5. [Article]
  6. Evans LD, Roszak AW, Noble LJ, Robinson DA, Chalk PA, Matthews JL, Coggins JR, Price NC, Lapthorn AJ: Specificity of substrate recognition by type II dehydroquinases as revealed by binding of polyanions. FEBS Lett. 2002 Oct 23;530(1-3):24-30. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB028012,3-Anhydro-quinic acidexperimentalunknownDetails
DB037393-Hydroxyimino Quinic AcidexperimentalunknownDetails