High affinity immunoglobulin epsilon receptor subunit beta

Details

Name
High affinity immunoglobulin epsilon receptor subunit beta
Synonyms
  • APY
  • Fc epsilon receptor I beta-chain
  • FCER1B
  • FcERI
  • IgE Fc receptor subunit beta
  • IGER
  • Membrane-spanning 4-domains subfamily A member 2
Gene Name
MS4A2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0011551|High affinity immunoglobulin epsilon receptor subunit beta
MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF
LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER
RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTE
IVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSP
PIDL
Number of residues
244
Molecular Weight
26533.365
Theoretical pI
4.78
GO Classification
Functions
IgE receptor activity
Processes
activation of phospholipase C activity / cytokine secretion / Fc-epsilon receptor signaling pathway / immune response / inflammatory response / innate immune response / positive regulation of mast cell degranulation / protein kinase C-activating G-protein coupled receptor signaling pathway / regulation of release of sequestered calcium ion into cytosol
Components
endosome / external side of plasma membrane / Fc-epsilon receptor I complex / integral component of plasma membrane / membrane raft / plasma membrane
General Function
Ige receptor activity
Specific Function
High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
Pfam Domain Function
Transmembrane Regions
60-79 98-117 131-150 181-200
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0011552|High affinity immunoglobulin epsilon receptor subunit beta (MS4A2)
ATGGACACAGAAAGTAATAGGAGAGCAAATCTTGCTCTCCCACAGGAGCCTTCCAGTGTG
CCTGCATTTGAAGTCTTGGAAATATCTCCCCAGGAAGTATCTTCAGGCAGACTATTGAAG
TCGGCCTCATCCCCACCACTGCATACATGGCTGACAGTTTTGAAAAAAGAGCAGGAGTTC
CTGGGGGTAACACAAATTCTGACTGCTATGATATGCCTTTGTTTTGGAACAGTTGTCTGC
TCTGTACTTGATATTTCACACATTGAGGGAGACATTTTTTCATCATTTAAAGCAGGTTAT
CCATTCTGGGGAGCCATATTTTTTTCTATTTCTGGAATGTTGTCAATTATATCTGAAAGG
AGAAATGCAACATATCTGGTGAGAGGAAGCCTGGGAGCAAACACTGCCAGCAGCATAGCT
GGGGGAACGGGAATTACCATCCTGATCATCAACCTGAAGAAGAGCTTGGCCTATATCCAC
ATCCACAGTTGCCAGAAATTTTTTGAGACCAAGTGCTTTATGGCTTCCTTTTCCACTGAA
ATTGTAGTGATGATGCTGTTTCTCACCATTCTGGGACTTGGTAGTGCTGTGTCACTCACA
ATCTGTGGAGCTGGGGAAGAACTCAAAGGAAACAAGGTTCCAGAGGATCGTGTTTATGAA
GAATTAAACATATATTCAGCTACTTACAGTGAGTTGGAAGACCCAGGGGAAATGTCTCCT
CCCATTGATTTATAA
Chromosome Location
11
Locus
11q13
External Identifiers
ResourceLink
UniProtKB IDQ01362
UniProtKB Entry NameFCERB_HUMAN
GenBank Protein ID219882
GenBank Gene IDD10583
GenAtlas IDMS4A2
HGNC IDHGNC:7316
General References
  1. Kuster H, Zhang L, Brini AT, MacGlashan DW, Kinet JP: The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. J Biol Chem. 1992 Jun 25;267(18):12782-7. [Article]
  2. Maekawa K, Imagawa N, Tanaka Y, Harada S: Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. FEBS Lett. 1992 May 11;302(2):161-5. [Article]
  3. Akizawa Y, Nishiyama C, Hasegawa M, Maeda K, Nakahata T, Okumura K, Ra C, Ogawa H: Regulation of human FcepsilonRI beta chain gene expression by Oct-1. Int Immunol. 2003 May;15(5):549-56. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Hill MR, Cookson WO: A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet. 1996 Jul;5(7):959-62. [Article]
  6. Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, Hopkin J: Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum Mol Genet. 1996 Aug;5(8):1129-30. [Article]
  7. Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, Hopkin J: Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum Mol Genet. 1996 Dec;5(12):2068. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00043Omalizumabapproved, investigationalyesinhibitorDetails