High affinity immunoglobulin epsilon receptor subunit beta
Details
- Name
- High affinity immunoglobulin epsilon receptor subunit beta
- Synonyms
- APY
- Fc epsilon receptor I beta-chain
- FCER1B
- FcERI
- IgE Fc receptor subunit beta
- IGER
- Membrane-spanning 4-domains subfamily A member 2
- Gene Name
- MS4A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011551|High affinity immunoglobulin epsilon receptor subunit beta MDTESNRRANLALPQEPSSVPAFEVLEISPQEVSSGRLLKSASSPPLHTWLTVLKKEQEF LGVTQILTAMICLCFGTVVCSVLDISHIEGDIFSSFKAGYPFWGAIFFSISGMLSIISER RNATYLVRGSLGANTASSIAGGTGITILIINLKKSLAYIHIHSCQKFFETKCFMASFSTE IVVMMLFLTILGLGSAVSLTICGAGEELKGNKVPEDRVYEELNIYSATYSELEDPGEMSP PIDL
- Number of residues
- 244
- Molecular Weight
- 26533.365
- Theoretical pI
- 4.78
- GO Classification
- FunctionsIgE receptor activityProcessesactivation of phospholipase C activity / cytokine secretion / Fc-epsilon receptor signaling pathway / immune response / inflammatory response / innate immune response / positive regulation of mast cell degranulation / protein kinase C-activating G-protein coupled receptor signaling pathway / regulation of release of sequestered calcium ion into cytosolComponentsendosome / external side of plasma membrane / Fc-epsilon receptor I complex / integral component of plasma membrane / membrane raft / plasma membrane
- General Function
- Ige receptor activity
- Specific Function
- High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
- Pfam Domain Function
- CD20 (PF04103)
- Transmembrane Regions
- 60-79 98-117 131-150 181-200
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0011552|High affinity immunoglobulin epsilon receptor subunit beta (MS4A2) ATGGACACAGAAAGTAATAGGAGAGCAAATCTTGCTCTCCCACAGGAGCCTTCCAGTGTG CCTGCATTTGAAGTCTTGGAAATATCTCCCCAGGAAGTATCTTCAGGCAGACTATTGAAG TCGGCCTCATCCCCACCACTGCATACATGGCTGACAGTTTTGAAAAAAGAGCAGGAGTTC CTGGGGGTAACACAAATTCTGACTGCTATGATATGCCTTTGTTTTGGAACAGTTGTCTGC TCTGTACTTGATATTTCACACATTGAGGGAGACATTTTTTCATCATTTAAAGCAGGTTAT CCATTCTGGGGAGCCATATTTTTTTCTATTTCTGGAATGTTGTCAATTATATCTGAAAGG AGAAATGCAACATATCTGGTGAGAGGAAGCCTGGGAGCAAACACTGCCAGCAGCATAGCT GGGGGAACGGGAATTACCATCCTGATCATCAACCTGAAGAAGAGCTTGGCCTATATCCAC ATCCACAGTTGCCAGAAATTTTTTGAGACCAAGTGCTTTATGGCTTCCTTTTCCACTGAA ATTGTAGTGATGATGCTGTTTCTCACCATTCTGGGACTTGGTAGTGCTGTGTCACTCACA ATCTGTGGAGCTGGGGAAGAACTCAAAGGAAACAAGGTTCCAGAGGATCGTGTTTATGAA GAATTAAACATATATTCAGCTACTTACAGTGAGTTGGAAGACCCAGGGGAAATGTCTCCT CCCATTGATTTATAA
- Chromosome Location
- 11
- Locus
- 11q13
- External Identifiers
Resource Link UniProtKB ID Q01362 UniProtKB Entry Name FCERB_HUMAN GenBank Protein ID 219882 GenBank Gene ID D10583 GenAtlas ID MS4A2 HGNC ID HGNC:7316 - General References
- Kuster H, Zhang L, Brini AT, MacGlashan DW, Kinet JP: The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor. J Biol Chem. 1992 Jun 25;267(18):12782-7. [Article]
- Maekawa K, Imagawa N, Tanaka Y, Harada S: Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor. FEBS Lett. 1992 May 11;302(2):161-5. [Article]
- Akizawa Y, Nishiyama C, Hasegawa M, Maeda K, Nakahata T, Okumura K, Ra C, Ogawa H: Regulation of human FcepsilonRI beta chain gene expression by Oct-1. Int Immunol. 2003 May;15(5):549-56. [Article]
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- Hill MR, Cookson WO: A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum Mol Genet. 1996 Jul;5(7):959-62. [Article]
- Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, Hopkin J: Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum Mol Genet. 1996 Aug;5(8):1129-30. [Article]
- Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, Hopkin J: Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum Mol Genet. 1996 Dec;5(12):2068. [Article]