14-3-3 protein eta
Details
- Name
- 14-3-3 protein eta
- Synonyms
- Protein AS1
- YWHA1
- Gene Name
- YWHAH
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049795|14-3-3 protein eta MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSW RVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESK VFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFS VFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDE EAGEGN
- Number of residues
- 246
- Molecular Weight
- 28218.445
- Theoretical pI
- Not Available
- GO Classification
- Functionsactin binding / enzyme binding / glucocorticoid receptor binding / insulin-like growth factor receptor binding / ion channel binding / protein domain specific binding / protein heterodimerization activity / sodium channel regulator activityProcessesglucocorticoid catabolic process / glucocorticoid receptor signaling pathway / intracellular protein transport / membrane depolarization during action potential / membrane organization / negative regulation of dendrite morphogenesis / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / positive regulation of transcription, DNA-templated / regulation of neuron differentiation / regulation of sodium ion transmembrane transporter activity / regulation of sodium ion transport / regulation of synaptic plasticity / substantia nigra developmentComponentscytoplasm / cytoplasmic vesicle membrane / cytosol / extracellular exosome / intercalated disc / mitochondrion / plasma membrane
- General Function
- Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
- Specific Function
- Actin binding
- Pfam Domain Function
- 14-3-3 (PF00244)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0049796|14-3-3 protein eta (YWHAH) ATGGGGGACCGGGAGCAGCTGCTGCAGCGGGCGCGGCTGGCCGAGCAGGCGGAGCGCTAC GACGACATGGCCTCCGCTATGAAGGCGGTGACAGAGCTGAATGAACCTCTCTCCAATGAA GATCGAAATCTCCTCTCTGTGGCCTACAAGAATGTGGTTGGTGCCAGGCGATCTTCCTGG AGGGTCATTAGCAGCATTGAGCAGAAAACCATGGCTGATGGAAACGAAAAGAAATTGGAG AAAGTTAAAGCTTACCGGGAGAAGATTGAGAAGGAGCTGGAGACAGTTTGCAATGATGTC CTGTCTCTGCTTGACAAGTTCCTGATCAAGAACTGCAATGATTTCCAGTATGAGAGCAAG GTGTTTTACCTGAAAATGAAGGGTGATTACTACCGCTACTTAGCAGAGGTCGCTTCTGGG GAGAAGAAAAACAGTGTGGTCGAAGCTTCTGAAGCTGCCTACAAGGAAGCCTTTGAAATC AGCAAAGAGCAGATGCAACCCACGCATCCCATCCGGCTGGGCCTGGCCCTCAACTTCTCC GTGTTCTACTATGAGATCCAGAATGCACCTGAGCAAGCCTGCCTCTTAGCCAAACAAGCC TTCGATGATGCCATAGCTGAGCTGGACACACTAAACGAGGATTCCTATAAGGACTCCACG CTGATCATGCAGTTGCTGCGAGACAACCTCACCCTCTGGACGAGCGACCAGCAGGATGAA GAAGCAGGAGAAGGCAACTGA
- Chromosome Location
- 22
- Locus
- 22q12.3
- External Identifiers
Resource Link UniProtKB ID Q04917 UniProtKB Entry Name 1433F_HUMAN HGNC ID HGNC:12853 - General References
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