Tyrosine-protein phosphatase non-receptor type 11

Details

Name
Tyrosine-protein phosphatase non-receptor type 11
Synonyms
  • 3.1.3.48
  • Protein-tyrosine phosphatase 1D
  • Protein-tyrosine phosphatase 2C
  • PTP-1D
  • PTP-2C
  • PTP2C
  • SH-PTP2
  • SH-PTP3
  • SHP-2
  • Shp2
  • SHPTP2
Gene Name
PTPN11
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002133|Tyrosine-protein phosphatase non-receptor type 11
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVW
QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI
DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK
RKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Number of residues
597
Molecular Weight
68436.0
Theoretical pI
7.31
GO Classification
Functions
insulin receptor binding / non-membrane spanning protein tyrosine phosphatase activity / phosphoprotein phosphatase activity / protein tyrosine phosphatase activity / SH3/SH2 adaptor activity
Processes
abortive mitotic cell cycle / activation of MAPK activity / atrioventricular canal development / axon guidance / blood coagulation / brain development / cytokine-mediated signaling pathway / DNA damage checkpoint / ephrin receptor signaling pathway / epidermal growth factor receptor signaling pathway / ERBB signaling pathway / face morphogenesis / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / genitalia development / glucose homeostasis / heart development / homeostasis of number of cells within a tissue / hormone metabolic process / hormone-mediated signaling pathway / innate immune response / inner ear development / insulin receptor signaling pathway / integrin-mediated signaling pathway / interferon-gamma-mediated signaling pathway / intestinal epithelial cell migration / leukocyte migration / megakaryocyte development / microvillus organization / multicellular organism growth / multicellular organismal reproductive process / negative regulation of cell adhesion mediated by integrin / negative regulation of cortisol secretion / negative regulation of growth hormone secretion / negative regulation of insulin secretion / neurotrophin TRK receptor signaling pathway / organ growth / peptidyl-tyrosine dephosphorylation / phosphatidylinositol-mediated signaling / platelet formation / platelet-derived growth factor receptor signaling pathway / positive regulation of ERK1 and ERK2 cascade / positive regulation of glucose import in response to insulin stimulus / positive regulation of hormone secretion / positive regulation of mitotic cell cycle / regulation of cell adhesion mediated by integrin / regulation of interferon-gamma-mediated signaling pathway / regulation of multicellular organism growth / regulation of protein complex assembly / regulation of protein export from nucleus / regulation of type I interferon-mediated signaling pathway / T cell costimulation / triglyceride metabolic process / type I interferon signaling pathway
Components
cytoplasm / cytosol / mitochondrion / nucleus / protein complex
General Function
Sh3/sh2 adaptor activity
Specific Function
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019058|Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)
ATGACATCGCGGAGATGGTTTCACCCAAATATCACTGGTGTGGAGGCAGAAAACCTACTG
TTGACAAGAGGAGTTGATGGCAGTTTTTTGGCAAGGCCTAGTAAAAGTAACCCTGGAGAC
TTCACACTTTCCGTTAGAAGAAATGGAGCTGTCACCCACATCAAGATTCAGAACACTGGT
GATTACTATGACCTGTATGGAGGGGAGAAATTTGCCACTTTGGCTGAGTTGGTCCAGTAT
TACATGGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTCATTGAGCTTAAATAT
CCTCTGAACTGTGCAGATCCTACCTCTGAAAGGTGGTTTCATGGACATCTCTCTGGGAAA
GAAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGTTTTCTTGTACGAGAGAGC
CAGAGCCACCCTGGAGATTTTGTTCTTTCTGTGCGCACTGGTGATGACAAAGGGGAGAGC
AATGACGGCAAGTCTAAAGTGACCCATGTTATGATTCGCTGTCAGGAACTGAAATACGAC
GTTGGTGGAGGAGAACGGTTTGATTCTTTGACAGATCTTGTGGAACATTATAAGAAGAAT
CCTATGGTGGAAACATTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACACGACTCGT
ATAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACA
GATAAAGTCAAACAAGGCTTTTGGGAAGAATTTGAGACACTACAACAACAGGAGTGCAAA
CTTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAA
AACATCCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGGTGATCCCAATGAGCCT
GTTTCAGATTACATCAATGCAAATATCATCATGCCTGAATTTGAAACCAAGTGCAACAAT
TCAAAGCCCAAAAAGAGTTACATTGCCACACAAGGCTGCCTGCAAAACACGGTGAATGAC
TTTTGGCGGATGGTGTTCCAAGAAAACTCCCGAGTGATTGTCATGACAACGAAAGAAGTG
GAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTCTAAAAGAATAT
GGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCCGCTCATGACTATACGCTAAGAGAA
CTTAAACTTTCAAAGGTTGGACAAGGGAATACGGAGAGAACGGTCTGGCAATACCACTTT
CGGACCTGGCCGGACCACGGCGTGCCCAGCGACCCTGGGGGCGTGCTGGACTTCCTGGAG
GAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAGGGCCGGTCGTGGTGCACTGCAGT
GCTGGAATTGGCCGGACAGGGACGTTCATTGTGATTGATATTCTTATTGACATCATCAGA
GAGAAAGGTGTTGACTGCGATATTGACGTTCCCAAAACCATCCAGATGGTGCGGTCTCAG
AGGTCAGGGATGGTCCAGACAGAAGCACAGTACCGATTTATCTATATGGCGGTCCAGCAT
TATATTGAAACACTACAGCGCAGGATTGAAGAAGAGCAGAAAAGCAAGAGGAAAGGGCAC
GAATATACAAATATTAAGTATTCTCTAGCGGACCAGACGAGTGGAGATCAGAGCCCTCTC
CCGCCTTGTACTCCAACGCCACCCTGTGCAGAAATGAGAGAAGACAGTGCTAGAGTCTAT
GAAAACGTGGGCCTGATGCAACAGCAGAAAAGTTTCAGATGA
Chromosome Location
12
Locus
12q24
External Identifiers
ResourceLink
UniProtKB IDQ06124
UniProtKB Entry NamePTN11_HUMAN
GenBank Protein ID4519425
GenBank Gene IDD13540
GenAtlas IDPTPN11
HGNC IDHGNC:9644
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02779DodecyltrimethylammoniumexperimentalunknownDetails