DNA repair protein RAD51 homolog 1

Details

Name
DNA repair protein RAD51 homolog 1
Synonyms
  • HsRAD51
  • RAD51 homolog A
  • RAD51A
  • RECA
Gene Name
RAD51
Organism
Humans
Amino acid sequence
>lcl|BSEQ0004737|DNA repair protein RAD51 homolog 1
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKEL
INIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGL
SGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSA
RQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRL
YLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
Number of residues
339
Molecular Weight
36965.82
Theoretical pI
5.29
GO Classification
Functions
ATP binding / chromatin binding / DNA polymerase binding / double-stranded DNA binding / four-way junction DNA binding / identical protein binding / protein C-terminus binding / recombinase activity / single-stranded DNA binding / single-stranded DNA-dependent ATPase activity
Processes
cellular response to camptothecin / cellular response to cisplatin / cellular response to DNA damage stimulus / cellular response to gamma radiation / cellular response to hydroxyurea / cellular response to ionizing radiation / chromosome organization involved in meiotic cell cycle / DNA recombination / DNA repair / DNA unwinding involved in DNA replication / double-strand break repair / double-strand break repair via homologous recombination / double-strand break repair via synthesis-dependent strand annealing / homologous recombination-dependent replication fork processing / meiotic nuclear division / mitotic recombination / positive regulation of DNA ligation / protein homooligomerization / reciprocal meiotic recombination / regulation of double-strand break repair via homologous recombination / regulation of protein phosphorylation / replication fork processing / replication-born double-strand break repair via sister chromatid exchange / response to drug / response to etoposide / response to toxic substance / response to X-ray / strand invasion / telomere organization
Components
chromatin / condensed chromosome / condensed nuclear chromosome / cytoplasm / lateral element / microtubule organizing center / mitochondrial matrix / mitochondrion / nuclear chromosome / nucleolus / nucleoplasm / nucleus / perinuclear region of cytoplasm / PML body / site of double-strand break
General Function
Single-stranded dna-dependent atpase activity
Specific Function
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0016783|DNA repair protein RAD51 homolog 1 (RAD51)
ATGGCAATGCAGATGCAGCTTGAAGCAAATGCAGATACTTCAGTGGAAGAAGAAAGCTTT
GGCCCACAACCCATTTCACGGTTAGAGCAGTGTGGCATAAATGCCAACGATGTGAAGAAA
TTGGAAGAAGCTGGATTCCATACTGTGGAGGCTGTTGCCTATGCGCCAAAGAAGGAGCTA
ATAAATATTAAGGGAATTAGTGAAGCCAAAGCTGATAAAATTCTGACGGAGTCTCGCTCT
GTTGCCAGGCTGGAGTGCAATAGCGTGATCTTGGTCTACTGCACCCTCCGCCTCTCAGGT
TCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGTTGGGACTACAGGTGGAATTGAGACT
GGATCTATCACAGAAATGTTTGGAGAATTCCGAACTGGGAAGACCCAGATCTGTCATACG
CTAGCTGTCACCTGCCAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTAC
ATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGT
CTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGACCAC
CAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTT
ATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCA
GCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAGTTT
GGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTT
GCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGA
TTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGT
CTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGAC
TGA
Chromosome Location
15
Locus
15q15.1
External Identifiers
ResourceLink
UniProtKB IDQ06609
UniProtKB Entry NameRAD51_HUMAN
GenBank Gene IDD13804
GenAtlas IDRAD51
HGNC IDHGNC:9817
General References
  1. Shinohara A, Ogawa H, Matsuda Y, Ushio N, Ikeo K, Ogawa T: Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. Nat Genet. 1993 Jul;4(3):239-43. [Article]
  2. Yoshimura Y, Morita T, Yamamoto A, Matsushiro A: Cloning and sequence of the human RecA-like gene cDNA. Nucleic Acids Res. 1993 Apr 11;21(7):1665. [Article]
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  4. Wang WW, Spurdle AB, Kolachana P, Bove B, Modan B, Ebbers SM, Suthers G, Tucker MA, Kaufman DJ, Doody MM, Tarone RE, Daly M, Levavi H, Pierce H, Chetrit A, Yechezkel GH, Chenevix-Trench G, Offit K, Godwin AK, Struewing JP: A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. Cancer Epidemiol Biomarkers Prev. 2001 Sep;10(9):955-60. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12742AmuvatinibinvestigationalunknownDetails
DB04395Phosphoaminophosphonic Acid-Adenylate EsterexperimentalunknownDetails