Serine/arginine-rich splicing factor 1
Details
- Name
- Serine/arginine-rich splicing factor 1
- Synonyms
- Alternative-splicing factor 1
- ASF
- ASF-1
- pre-mRNA-splicing factor SF2, P33 subunit
- SF2
- SF2P33
- SFRS1
- Splicing factor, arginine/serine-rich 1
- Gene Name
- SRSF1
- UniProtKB Entry
- Q07955Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0051314|Serine/arginine-rich splicing factor 1 MSGGGVIRGPAGNNDCRIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVE FEDPRDAEDAVYGRDGYDYDGYRLRVEFPRSGRGTGRGGGGGGGGGAPRGRYGPPSRRSE NRVVVSGLPPSGSWQDLKDHMREAGDVCYADVYRDGTGVVEFVRKEDMTYAVRKLDNTKF RSHEGETAYIRVKVDGPRSPSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRGSPRYSPR HSRSRSRT
- Number of residues
- 248
- Molecular Weight
- 27744.335
- Theoretical pI
- Not Available
- GO Classification
- ProcessesmRNA splice site recognition / mRNA transport / regulation of RNA splicingComponentsnuclear envelope
- General Function
- Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway
- Specific Function
- DNA topoisomerase binding
- Pfam Domain Function
- RRM_1 (PF00076)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051315|Serine/arginine-rich splicing factor 1 (SRSF1) ATGTCGGGAGGTGGTGTGATTCGTGGCCCCGCAGGGAACAACGATTGCCGCATCTACGTG GGTAACTTACCTCCAGACATCCGAACCAAGGACATTGAGGACGTGTTCTACAAATACGGC GCTATCCGCGACATCGACCTCAAGAATCGCCGCGGGGGACCGCCCTTCGCCTTCGTTGAG TTCGAGGACCCGCGAGACGCGGAAGACGCGGTGTATGGTCGCGACGGCTATGATTACGAT GGGTACCGTCTGCGGGTGGAGTTTCCTCGAAGCGGCCGTGGAACAGGCCGAGGCGGCGGC GGGGGTGGAGGTGGCGGAGCTCCCCGAGGTCGCTATGGCCCCCCATCCAGGCGGTCTGAA AACAGAGTGGTTGTCTCTGGACTGCCTCCAAGTGGAAGTTGGCAGGATTTAAAGGATCAC ATGCGTGAAGCAGGTGATGTATGTTATGCTGATGTTTACCGAGATGGCACTGGTGTCGTG GAGTTTGTACGGAAAGAAGATATGACCTATGCAGTTCGAAAACTGGATAACACTAAGTTT AGATCTCATGAGGGAGAAACTGCCTACATCCGGGTTAAAGTTGATGGGCCCAGAAGTCCA AGTTATGGAAGATCTCGATCTCGAAGCCGTAGTCGTAGCAGAAGCCGTAGCAGAAGCAAC AGCAGGAGTCGCAGTTACTCCCCAAGGAGAAGCAGAGGATCACCACGCTATTCTCCCCGT CATAGCAGATCTCGCTCTCGTACATAA
- Chromosome Location
- 17
- Locus
- 17q22
- External Identifiers
Resource Link UniProtKB ID Q07955 UniProtKB Entry Name SRSF1_HUMAN GeneCard ID SRSF1 HGNC ID HGNC:10780 PDB ID(s) 1X4A, 2M7S, 2M8D, 2O3D, 3BEG, 4C0O, 6HPJ, 7ABG, 8QO9 KEGG ID hsa:6426 NCBI Gene ID 6426 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Serine/arginine-rich splicing factor 1 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Copper approved, investigational unknown target Details