Serine/arginine-rich splicing factor 4

Details

Name
Serine/arginine-rich splicing factor 4
Synonyms
  • Pre-mRNA-splicing factor SRP75
  • SFRS4
  • Splicing factor, arginine/serine-rich 4
  • SRP001LB
  • SRP75
Gene Name
SRSF4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049948|Serine/arginine-rich splicing factor 4
MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDL
CGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDL
KDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSR
RRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRS
RSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKS
RSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRS
REESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKS
ESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSAS
RSPSRSRSRSHSRS
Number of residues
494
Molecular Weight
56677.745
Theoretical pI
Not Available
GO Classification
Functions
RNA binding / sequence-specific mRNA binding
Processes
mRNA 3'-end processing / mRNA export from nucleus / mRNA processing / mRNA splicing, via spliceosome / negative regulation of mRNA splicing, via spliceosome / response to insulin / RNA export from nucleus / RNA splicing / RNA splicing, via transesterification reactions / termination of RNA polymerase II transcription
Components
nuclear speck / nucleoplasm / nucleus
General Function
Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
Specific Function
Rna binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus speckle
Gene sequence
>lcl|BSEQ0049949|Serine/arginine-rich splicing factor 4 (SRSF4)
ATGCCGCGGGTGTACATCGGCCGCCTGAGCTACCAGGCCCGGGAGCGCGATGTGGAGCGC
TTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGATATGGTTTTGTG
GAGTTTGATGATCTGCGTGATGCAGATGATGCTGTTTATGAACTGAATGGCAAAGACCTT
TGTGGTGAGCGAGTAATTGTTGAGCATGCCCGCGGCCCACGGCGAGATGGCAGTTACGGT
TCTGGACGCAGTGGATATGGTTATAGAAGAAGTGGCCGAGATAAATATGGCCCTCCTACT
CGCACAGAGTACAGACTTATTGTGGAGAATTTGTCAAGTCGGTGCAGCTGGCAAGACCTA
AAGGATTATATGCGTCAGGCAGGAGAAGTGACTTATGCAGATGCTCACAAGGGACGCAAA
AATGAAGGGGTGATTGAATTTGTATCTTATTCTGATATGAAAAGAGCTTTGGAAAAGTTG
GATGGAACTGAAGTCAATGGGAGAAAAATCAGATTAGTTGAAGACAAGCCAGGTTCCAGA
CGACGCCGGTCCTACTCCAGAAGCCGGAGTCATTCAAGGTCTCGCTCTCGAAGCAGACAT
TCCCGTAAGAGCAGAAGCCGAAGTGGCAGCAGCAAAAGCAGTCATTCTAAGAGTAGATCT
CGGTCCAGGTCGGGCTCCCGCTCCCGGAGCAAGAGCCGGAGCCGGAGCCAGAGTCGGAGC
CGGAGCAAGAAAGAGAAAAGCAGGAGCCCCAGCAAGGAAAAGAGCCGCAGCCGCAGCCAT
AGCGCTGGCAAGAGCCGCAGCAAGAGCAAAGACCAAGCTGAAGAGAAGATCCAAAACAAT
GACAATGTCGGGAAACCCAAGAGCCGGAGTCCTAGCAGGCATAAAAGTAAGAGCAAAAGT
CGGAGCAGGAGTCAGGAGAGGAGAGTGGAGGAGGAGAAGCGAGGGAGTGTGAGCAGGGGC
AGGAGCCAGGAGAAGAGCCTCCGCCAGAGTCGGAGCCGGAGCAGGAGCAAAGGGGGCAGC
AGGAGCCGGAGCAGGAGCCGCAGCAAGAGCAAGGACAAGAGGAAGGGCAGGAAGAGAAGC
AGAGAGGAGAGCCGCAGTCGCAGTCGCAGCCGCAGCAAGAGTGAGAGGAGCAGAAAGCGA
GGCAGCAAGCGAGACAGCAAGGCGGGCAGCAGCAAGAAGAAGAAGAAGGAAGACACTGAC
CGCTCCCAGTCCAGATCTCCATCCCGCTCCGTGTCAAAGGAGCGGGAACATGCCAAGTCT
GAATCCAGCCAGAGGGAAGGTCGAGGAGAGAGTGAGAATGCTGGCACCAATCAGGAGACC
CGGTCCAGGTCGAGATCCAATTCCAAATCGAAACCAAACCTTCCATCAGAATCACGCTCC
AGATCAAAGTCAGCTTCAAAAACCCGATCTCGGTCCAAGTCTAGATCCAGGTCTGCTTCC
AGATCGCCCTCCCGATCTAGATCTAGGTCCCACTCAAGGTCCTAA
Chromosome Location
1
Locus
1p35.3
External Identifiers
ResourceLink
UniProtKB IDQ08170
UniProtKB Entry NameSRSF4_HUMAN
HGNC IDHGNC:10786
General References
  1. Zahler AM, Neugebauer KM, Stolk JA, Roth MB: Human SR proteins and isolation of a cDNA encoding SRp75. Mol Cell Biol. 1993 Jul;13(7):4023-8. [Article]
  2. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Zahler AM, Lane WS, Stolk JA, Roth MB: SR proteins: a conserved family of pre-mRNA splicing factors. Genes Dev. 1992 May;6(5):837-47. [Article]
  5. Blencowe BJ, Issner R, Nickerson JA, Sharp PA: A coactivator of pre-mRNA splicing. Genes Dev. 1998 Apr 1;12(7):996-1009. [Article]
  6. Wang J, Gao QS, Wang Y, Lafyatis R, Stamm S, Andreadis A: Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem. 2004 Mar;88(5):1078-90. [Article]
  7. Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP: Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4715-23. [Article]
  8. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
  9. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  10. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  11. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
  12. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
  13. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11638Artenimolapproved, experimental, investigationalunknownligandDetails