Kinesin-like protein KIF1A

Details

Name
Kinesin-like protein KIF1A
Synonyms
  • ATSV
  • Axonal transporter of synaptic vesicles
  • C2orf20
  • hUnc-104
  • Microtubule-based motor KIF1A
  • Unc-104- and KIF1A-related protein
Gene Name
KIF1A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006080|Kinesin-like protein KIF1A
MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHT
SPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIP
QLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVED
LSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK
VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKK
TDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVI
NEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVGMSPSSSLSALSSRAASVSSL
HERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG
GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGREDGERRQDIVLSGHFIKEEH
CVFRSDSRGGSEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQA
RQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQRLQELEDQYRREREEATYLL
EQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT
SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF
PRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVIEDCDNVVTGGDPF
YDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYG
SGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADVGPSADEV
NNNTCSAVPPEGLLLDSSEKAALDGPLDAALDHLRLGNTFTFRVTVLQASSISAEYADIF
CQFNFIHRHDEAFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHY
QQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTLTRPCPGPCHCKYDLLVYFE
ICELEANGDYIPAVVDHRGGMPCMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVG
RIRNTPETDESLIDPNILSLNILSSGYIHPAQDDRTFYQFEAAWDSSMHNSLLLNRVTPY
REKIYMTLSAYIEMENCTQPAVVTKDFCMVFYSRDAKLPASRSIRNLFGSGSLRASESNR
VTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELE
KLSLLQEVEKTRHYLLLREKLETAQRPVPEALSPAFSEDSESHGSSSASSPLSAEGRPSP
LEAPNERQRELAVKCLRLLTHTFNREYTHSHVCVSASESKLSEMSVTLLRDPSMSPLGVA
TLTPSSTCPSLVEGRYGATDLRTPQPCSRPASPEPELLPEADSKKLPSPARATETDKEPQ
RLLVPDIQEIRVSPIVSKKGYLHFLEPHTSGWARRFVVVRRPYAYMYNSDKDTVERFVLN
LATAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQAASDKDMHDWLYAFNPLLAGTIRSKL
SRRRSAQMRV
Number of residues
1690
Molecular Weight
191062.325
Theoretical pI
6.13
GO Classification
Functions
ATP binding / ATP-dependent microtubule motor activity, plus-end-directed / motor activity
Processes
anterograde axon cargo transport / vesicle-mediated transport
Components
cytoplasm / kinesin complex / microtubule / neuron projection / neuronal cell body
General Function
Motor activity
Specific Function
Motor for anterograde axonal transport of synaptic vesicle precursors.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012181|Kinesin-like protein KIF1A (KIF1A)
ATGGCCGGGGCTTCGGTGAAGGTGGCGGTGCGGGTCCGCCCCTTCAATTCCCGGGAAATG
AGCCGTGACTCCAAGTGCATCATTCAGATGTCTGGAAGCACCACCACCATTGTTAACCCC
AAACAGCCCAAGGAGACGCCCAAAAGCTTCAGCTTTGACTACTCCTACTGGTCGCACACC
TCACCTGAGGACATCAACTACGCGTCGCAGAAGCAGGTGTACCGGGACATCGGCGAGGAG
ATGCTGCAGCATGCCTTTGAGGGATACAACGTGTGCATCTTCGCCTATGGGCAGACGGGT
GCCGGCAAGTCCTACACCATGATGGGCAAGCAGGAGAAGGACCAGCAGGGCATCATCCCA
CAGCTCTGCGAGGACCTCTTCTCTCGGATCAACGACACGACCAACGACAACATGTCCTAC
TCCGTGGAGGTCAGCTACATGGAGATTTACTGTGAGCGCGTCCGTGACCTCCTGAACCCC
AAGAACAAGGGCAACCTTCGCGTGAGGGAGCACCCACTGCTGGGGCCCTACGTGGAGGAC
CTCTCCAAGCTGGCTGTCACCTCCTACAATGACATCCAGGACCTCATGGACTCAGGGAAC
AAGGCCAGGACCGTGGCGGCCACCAACATGAATGAGACCAGCAGTCGCTCCCACGCCGTC
TTCAACATCATCTTCACCCAGAAGCGCCATGACGCAGAGACCAATATCACCACGGAGAAG
GTGAGCAAAATCAGCCTGGTGGACCTGGCTGGGAGCGAGCGGGCTGACTCCACGGGAGCC
AAGGGCACGCGCCTCAAGGAGGGGGCCAACATCAACAAGTCGCTGACCACCCTGGGCAAG
GTCATCTCCGCCCTGGCTGAAATGGACTCCGGACCCAACAAGAACAAGAAAAAGAAGAAG
ACAGATTTCATTCCGTACCGAGATTCCGTGTTGACCTGGCTCCTCCGGGAAAACCTGGGC
GGTAACTCAAGGACAGCTATGGTGGCAGCCTTGAGTCCTGCAGACATCAACTACGATGAG
ACCCTTAGCACGCTGAGGTATGCTGACCGGGCCAAGCAGATCCGCTGCAATGCTGTCATC
AATGAGGACCCCAACAACAAGCTGATCCGCGAGCTGAAGGATGAGGTGACCCGGCTGCGG
GACCTTCTGTACGCCCAGGGTCTTGGCGACATCACTGACACCAACACTGTGCCTGGAGGA
CCCAAATTGACCAATGCCCTGGTGGGTATGAGCCCCTCATCCTCGCTCTCAGCCCTGTCC
AGCCGCGCGGCCTCCGTGTCCAGCCTCCACGAGCGCATCTTGTTTGCCCCGGGCAGCGAG
GAGGCCATTGAAAGACTGAAGGAAACAGAGAAGATCATAGCTGAGCTCAATGAGACCTGG
GAGGAGAAGCTGCGGCGGACAGAAGCCATCCGGATGGAGAGGGAAGCCCTGCTGGCCGAG
ATGGGTGTGGCCATGAGGGAGGATGGCGGCACCTTGGGCGTATTCTCTCCCAAAAAGACA
CCACACCTCGTCAACCTGAACGAGGACCCGCTGATGTCTGAGTGCCTGCTCTACTACATC
AAGGATGGGATCACCAGAGTGGGCAGGGAGGATGGCGAGAGGCGGCAGGACATTGTTCTG
AGTGGGCACTTCATCAAGGAGGAGCACTGCGTCTTCCGGAGCGACTCCAGGGGAGGCAGC
GAAGCTGTGGTGACCTTGGAGCCCTGTGAGGGGGCAGACACCTACGTCAATGGCAAGAAA
GTCACAGAGCCCAGCATCCTGCGTTCAGGAAACCGCATCATCATGGGTAAGAGCCATGTG
TTCCGGTTCAACCACCCCGAGCAGGCCCGGCAGGAGCGTGAGCGCACGCCTTGTGCGGAG
ACGCCAGCTGAGCCTGTGGACTGGGCCTTCGCCCAGCGTGAGCTGCTGGAGAAGCAGGGC
ATCGACATGAAGCAGGAGATGGAGCAGAGGCTCCAGGAACTGGAGGACCAGTACCGCCGC
GAGCGGGAGGAGGCCACCTACCTGCTGGAGCAGCAGCGGCTGGACTATGAGAGCAAGCTG
GAGGCTCTGCAGAAGCAGATGGACTCCAGGTACTACCCGGAGGTGAACGAGGAGGAGGAG
GAGCCCGAGGATGAAGTCCAGTGGACAGAGCGGGAGTGTGAGCTGGCGCTCTGGGCCTTC
CGGAAGTGGAAGTGGTACCAGTTCACGTCTCTGCGGGACCTGCTGTGGGGCAACGCCATC
TTCCTCAAGGAGGCCAATGCCATCAGCGTGGAGCTGAAAAAGAAGGTACAATTCCAGTTT
GTCCTCCTGACGGACACACTCTACTCCCCTCTGCCACCCGACCTGCTGCCCCCAGAGGCC
GCCAAAGACCGAGAGACGCGGCCCTTCCCCCGCACCATTGTGGCCGTGGAGGTCCAGGAC
CAGAAGAACGGGGCCACCCACTACTGGACGCTGGAGAAGCTCAGGCAGCGTCTGGACCTG
ATGCGGGAGATGTACGACCGCGCTGCAGAGGTGCCCTCCAGTGTCATCGAGGACTGTGAC
AACGTGGTGACCGGCGGAGACCCCTTCTATGACCGCTTCCCCTGGTTCCGGCTGGTGGGC
AGTTCAGCCATCTCTGGCTGCAACAGCTACCCTCTTCTCAACACATGCATGAGCGAGCGC
ATGGCTGCTCTCACCCCCTCCCCCACCTTCTCGAGCCCCGACTCCGACGCCACCGAGCCT
GCCGAGGAGCAGAGCGTGGGGGAGGAGGAGGAGGAGGAGGAGGAGGAGGAGGATGAGGAG
GAGGAGGACCTGGAGGACGACGTCTTTCCGGAGCACGCGCTGTGCGACGGCCGGGACCCG
TTTTACGACCGGCCCCCCCTGTTCAGTTTAGTAGGAAGGGCCTTCGTGTACCTGAGCAAC
CTGCTGTACCCCGTTCCCCTGGTACACCGTGTGGCAATCGTCAGCGAGAAGGGCGAGGTG
AAGGGCTTCCTCCGCGTGGCCGTCCAGGCCATCTCAGCCGATGAAGAGGCCCCTGATTAT
GGCTCTGGCGTCCGCCAGTCGGGAACTGCTAAAATCTCCTTTGATGACCAGCATTTTGAA
AAGTTCCAGTCCGAGTCTTGCCCCGTGGTGGGGATGTCCCGCTCGGGAACCTCCCAGGAA
GAGCTTCGCATCGTGGAGGGCCAGGGCCAGGGTGCAGACGTGGGGCCCTCAGCCGATGAA
GTCAACAACAACACCTGTTCAGCAGTGCCCCCAGAAGGCCTCCTCCTAGACAGCTCTGAG
AAAGCCGCCCTGGATGGGCCCCTGGATGCTGCCCTGGACCACCTCCGCCTGGGCAACACC
TTCACCTTCCGTGTGACAGTCCTGCAGGCGTCCAGCATCTCTGCCGAATATGCCGACATC
TTCTGCCAGTTCAACTTCATCCACCGCCACGACGAGGCCTTCTCCACAGAGCCCCTGAAG
AACACAGGCAGAGGCCCCCCACTTGGCTTCTACCACGTCCAGAACATCGCAGTGGAGGTG
ACCAAGTCCTTCATTGAGTACATCAAGAGCCAGCCCATTGTTTTCGAGGTCTTTGGCCAC
TACCAGCAGCACCCGTTCCCGCCCCTCTGCAAGGACGTGCTCAGCCCCCTGAGGCCCTCG
CGCCGCCACTTCCCTCGGGTCATGCCACTGTCCAAGCCAGTGCCCGCCACCAAGCTCAGC
ACACTGACGCGGCCCTGTCCGGGACCCTGCCACTGCAAGTACGACCTGCTGGTCTACTTC
GAGATCTGTGAGCTGGAGGCCAACGGCGATTACATCCCGGCCGTGGTGGACCACCGTGGG
GGCATGCCATGCATGGGGACCTTCCTCCTCCACCAGGGCATCCAGCGACGGATTACGGTG
ACACTACTGCATGAGACAGGCAGCCATATCCGCTGGAAGGAAGTGCGCGAGCTGGTCGTG
GGCCGCATCCGAAACACTCCAGAGACCGACGAGTCCCTGATCGACCCCAACATCTTGTCT
CTCAACATCCTCTCTTCCGGATACATCCACCCAGCCCAAGATGACCGGACCTTTTACCAA
TTTGAGGCTGCGTGGGACAGCTCCATGCACAACTCTCTCCTGCTGAACCGGGTCACCCCT
TATCGAGAGAAAATCTACATGACACTCTCCGCTTATATCGAGATGGAGAACTGCACCCAG
CCGGCTGTTGTCACCAAGGACTTCTGCATGGTCTTCTATTCCCGTGATGCCAAGCTGCCA
GCCTCGCGCTCCATCCGCAACCTCTTTGGCAGTGGGAGCCTTCGGGCCTCAGAGAGTAAC
CGTGTGACTGGTGTGTACGAGCTCAGCCTGTGCCACGTGGCTGACGCGGGCAGCCCAGGG
ATGCAGCGCCGGCGCCGACGAGTCCTGGACACATCTGTGGCCTATGTCCGGGGCGAGGAG
AACCTGGCAGGCTGGAGGCCCCGGAGTGACAGTCTCATTCTGGACCACCAGTGGGAGCTG
GAGAAGCTGAGCCTCCTGCAGGAGGTGGAGAAGACTAGGCACTACCTGCTCCTGCGGGAG
AAGCTGGAGACCGCCCAGCGGCCTGTCCCGGAGGCACTGTCCCCGGCCTTCAGCGAGGAC
TCTGAGTCCCATGGCTCCTCCAGCGCCTCCTCCCCGCTCTCGGCTGAGGGCCGCCCATCA
CCCCTGGAGGCTCCCAACGAGAGGCAGCGGGAGCTGGCCGTCAAGTGCTTGCGCCTGCTC
ACGCACACATTCAACAGAGAGTACACACACAGCCACGTCTGCGTCAGTGCCAGCGAGAGC
AAGCTCTCCGAGATGTCTGTCACCCTGCTCCGGGACCCGTCGATGTCCCCTCTAGGGGTG
GCCACTCTCACCCCCTCCTCCACTTGCCCCTCTCTGGTTGAAGGGCGGTACGGTGCCACT
GACCTGAGGACCCCGCAGCCCTGCTCCCGGCCAGCCAGCCCAGAGCCCGAGCTGCTGCCA
GAGGCCGACTCCAAGAAGCTCCCTTCCCCTGCCCGGGCAACAGAGACAGACAAGGAGCCC
CAGCGCCTGCTGGTCCCTGACATCCAGGAGATCCGAGTCAGCCCGATCGTTTCCAAGAAG
GGGTACCTGCACTTCCTGGAGCCGCACACGTCAGGCTGGGCCAGGCGCTTCGTGGTGGTG
CGGCGCCCCTATGCCTACATGTACAACAGCGACAAGGACACCGTGGAGCGGTTCGTGCTC
AACCTGGCCACTGCCCAGGTGGAGTACAGTGAGGACCAGCAGGCTATGCTCAAGACACCC
AACACATTCGCGGTGTGCACGGAACACCGCGGCATCCTGCTGCAGGCCGCCAGCGACAAG
GACATGCATGACTGGCTGTACGCCTTCAACCCCCTCCTGGCCGGGACCATACGGTCCAAG
CTCTCCAGAAGGAGGTCTGCCCAGATGCGGGTCTGA
Chromosome Location
2
Locus
2q37.3
External Identifiers
ResourceLink
UniProtKB IDQ12756
UniProtKB Entry NameKIF1A_HUMAN
GenBank Gene IDX90840
GenAtlas IDKIF1A
HGNC IDHGNC:888
General References
  1. Furlong RA, Zhou CY, Ferguson-Smith MA, Affara NA: Characterization of a kinesin-related gene ATSV, within the tuberous sclerosis locus (TSC1) candidate region on chromosome 9Q34. Genomics. 1996 May 1;33(3):421-9. [Article]
  2. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  5. Riviere JB, Ramalingam S, Lavastre V, Shekarabi M, Holbert S, Lafontaine J, Srour M, Merner N, Rochefort D, Hince P, Gaudet R, Mes-Masson AM, Baets J, Houlden H, Brais B, Nicholson GA, Van Esch H, Nafissi S, De Jonghe P, Reilly MM, Timmerman V, Dion PA, Rouleau GA: KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. Am J Hum Genet. 2011 Aug 12;89(2):219-30. doi: 10.1016/j.ajhg.2011.06.013. Epub 2011 Aug 4. [Article]
  6. Hamdan FF, Gauthier J, Araki Y, Lin DT, Yoshizawa Y, Higashi K, Park AR, Spiegelman D, Dobrzeniecka S, Piton A, Tomitori H, Daoud H, Massicotte C, Henrion E, Diallo O, Shekarabi M, Marineau C, Shevell M, Maranda B, Mitchell G, Nadeau A, D'Anjou G, Vanasse M, Srour M, Lafreniere RG, Drapeau P, Lacaille JC, Kim E, Lee JR, Igarashi K, Huganir RL, Rouleau GA, Michaud JL: Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability. Am J Hum Genet. 2011 Mar 11;88(3):306-16. doi: 10.1016/j.ajhg.2011.02.001. Epub 2011 Mar 3. [Article]
  7. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
  8. Erlich Y, Edvardson S, Hodges E, Zenvirt S, Thekkat P, Shaag A, Dor T, Hannon GJ, Elpeleg O: Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis. Genome Res. 2011 May;21(5):658-64. doi: 10.1101/gr.117143.110. Epub 2011 Apr 12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03909Adenosine-5'-[Beta, Gamma-Methylene]TriphosphateexperimentalunknownDetails
DB04395Phosphoaminophosphonic Acid-Adenylate EsterexperimentalunknownDetails