Hyaluronidase-1
Details
- Name
- Hyaluronidase-1
- Synonyms
- 3.2.1.35
- Hyal-1
- Hyaluronoglucosaminidase-1
- LuCa-1
- LUCA1
- Lung carcinoma protein 1
- Gene Name
- HYAL1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052543|Hyaluronidase-1 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC YPGWQAPWCERKSMW
- Number of residues
- 435
- Molecular Weight
- 48367.73
- Theoretical pI
- Not Available
- GO Classification
- Functionshyaluronan synthase activity / hyalurononglucosaminidase activity / transcription factor bindingProcessescarbohydrate metabolic process / cartilage development / cellular response to fibroblast growth factor stimulus / cellular response to interleukin-1 / cellular response to pH / cellular response to platelet-derived growth factor stimulus / cellular response to tumor necrosis factor / cellular response to UV-B / chondroitin sulfate catabolic process / embryonic skeletal joint morphogenesis / hyaluronan biosynthetic process / hyaluronan catabolic process / hyaluronan metabolic process / inflammatory response / negative regulation of cell growth / positive regulation of angiogenesis / positive regulation of cell adhesion / positive regulation of cell growth / positive regulation of epithelial cell migration / positive regulation of epithelial cell proliferation / positive regulation of G1/S transition of mitotic cell cycle / positive regulation of growth / positive regulation of hyaluranon cable assembly / response to antibiotic / response to reactive oxygen species / response to virus / viral entry into host cellComponentscytoplasm / cytoplasmic vesicle / extracellular exosome / extracellular space / hyaluranon cable / lysosomal lumen / lysosome
- General Function
- May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
- Specific Function
- Hyaluronan synthase activity
- Pfam Domain Function
- Glyco_hydro_56 (PF01630)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0052544|Hyaluronidase-1 (HYAL1) ATGGCAGCCCACCTGCTTCCCATCTGCGCCCTCTTCCTGACCTTACTCGATATGGCCCAA GGCTTTAGGGGCCCCTTGCTACCCAACCGGCCCTTCACCACCGTCTGGAATGCAAACACC CAGTGGTGCCTGGAGAGGCACGGTGTGGACGTGGATGTCAGTGTCTTCGATGTGGTAGCC AACCCAGGGCAGACCTTCCGCGGCCCTGACATGACAATTTTCTATAGCTCCCAGCTGGGC ACCTACCCCTACTACACGCCCACTGGGGAGCCTGTGTTTGGTGGTCTGCCCCAGAATGCC AGCCTGATTGCCCACCTGGCCCGCACATTCCAGGACATCCTGGCTGCCATACCTGCTCCT GACTTCTCAGGGCTGGCAGTCATCGACTGGGAGGCATGGCGCCCACGCTGGGCCTTCAAC TGGGACACCAAGGACATTTACCGGCAGCGCTCACGGGCACTGGTACAGGCACAGCACCCT GATTGGCCAGCTCCTCAGGTGGAGGCAGTAGCCCAGGACCAGTTCCAGGGAGCTGCACGG GCCTGGATGGCAGGCACCCTCCAGCTGGGGCGGGCACTGCGTCCTCGCGGCCTCTGGGGC TTCTATGGCTTCCCTGACTGCTACAACTATGACTTTCTAAGCCCCAACTACACCGGCCAG TGCCCATCAGGCATCCGTGCCCAAAATGACCAGCTAGGGTGGCTGTGGGGCCAGAGCCGT GCCCTCTATCCCAGCATCTACATGCCCGCAGTGCTGGAGGGCACAGGGAAGTCACAGATG TATGTGCAACACCGTGTGGCCGAGGCATTCCGTGTGGCTGTGGCTGCTGGTGACCCCAAT CTGCCGGTGCTGCCCTATGTCCAGATCTTCTATGACACGACAAACCACTTTCTGCCCCTG GATGAGCTGGAGCACAGCCTGGGGGAGAGTGCGGCCCAGGGGGCAGCTGGAGTGGTGCTC TGGGTGAGCTGGGAAAATACAAGAACCAAGGAATCATGTCAGGCCATCAAGGAGTATATG GACACTACACTGGGGCCCTTCATCCTGAACGTGACCAGTGGGGCCCTTCTCTGCAGTCAA GCCCTGTGCTCCGGCCATGGCCGCTGTGTCCGCCGCACCAGCCACCCCAAAGCCCTCCTC CTCCTTAACCCTGCCAGTTTCTCCATCCAGCTCACGCCTGGTGGTGGGCCCCTGAGCCTG CGGGGTGCCCTCTCACTTGAAGATCAGGCACAGATGGCTGTGGAGTTCAAATGTCGATGC TACCCTGGCTGGCAGGCACCGTGGTGTGAGCGGAAGAGCATGTGGTGA
- Chromosome Location
- 3
- Locus
- 3p21.31
- External Identifiers
Resource Link UniProtKB ID Q12794 UniProtKB Entry Name HYAL1_HUMAN HGNC ID HGNC:5320 - General References
- Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI: Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. Cancer Res. 1996 Apr 1;56(7):1487-92. [Article]
- Frost GI, Csoka AB, Wong T, Stern R: Purification, cloning, and expression of human plasma hyaluronidase. Biochem Biophys Res Commun. 1997 Jul 9;236(1):10-5. [Article]
- Frost GI, Mohapatra G, Wong TM, Csoka AB, Gray JW, Stern R: HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. Oncogene. 2000 Feb 17;19(7):870-7. [Article]
- Lokeshwar VB, Schroeder GL, Carey RI, Soloway MS, Iida N: Regulation of hyaluronidase activity by alternative mRNA splicing. J Biol Chem. 2002 Sep 13;277(37):33654-63. Epub 2002 Jun 25. [Article]
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- Chao KL, Muthukumar L, Herzberg O: Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis. Biochemistry. 2007 Jun 12;46(23):6911-20. Epub 2007 May 16. [Article]
- Triggs-Raine B, Salo TJ, Zhang H, Wicklow BA, Natowicz MR: Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6296-300. [Article]