Splicing factor 3A subunit 3

Details

Name
Splicing factor 3A subunit 3
Synonyms
  • SAP 61
  • SAP61
  • SF3a60
  • Spliceosome-associated protein 61
Gene Name
SF3A3
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049781|Splicing factor 3A subunit 3
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDL
YDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENP
SEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNA
EYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQAEFEKKWENGTFPGWPKETSSALTHA
GAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSL
FAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEE
EEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPK
AFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYE
DSSGNVVNKKTYEDLKRQGLL
Number of residues
501
Molecular Weight
58848.42
Theoretical pI
Not Available
GO Classification
Functions
RNA binding / zinc ion binding
Processes
mRNA 3'-splice site recognition / mRNA processing / mRNA splicing, via spliceosome / RNA splicing / RNA splicing, via transesterification reactions
Components
catalytic step 2 spliceosome / nuclear speck / nucleoplasm / spliceosomal complex
General Function
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Specific Function
Rna binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus speckle
Gene sequence
>lcl|BSEQ0049782|Splicing factor 3A subunit 3 (SF3A3)
ATGGAGACAATACTGGAGCAGCAGCGGCGCTATCATGAGGAGAAGGAACGGCTCATGGAC
GTCATGGCTAAAGAGATGCTCACCAAGAAGTCCACGCTCCGGGACCAGATCAATTCTGAT
CACCGCACTCGGGCCATGCAAGATAGGTATATGGAGGTCAGTGGGAACCTGAGGGATTTG
TATGATGATAAGGATGGATTACGAAAGGAGGAGCTCAATGCCATTTCAGGACCCAATGAG
TTTGCTGAATTCTATAATAGACTCAAGCAAATAAAGGAATTCCACCGGAAGCACCCAAAT
GAGATCTGTGTGCCAATGTCAGTGGAATTTGAGGAACTCCTGAAGGCTCGAGAGAATCCA
AGTGAAGAGGCACAAAACTTGGTGGAGTTCACAGATGAAGAGGGATATGGTCGTTATCTC
GATCTCCATGACTGTTACCTCAAGTACATTAACCTGAAGGCATCTGAGAAGCTGGATTAT
ATCACATACCTGTCCATCTTTGACCAATTATTTGACATTCCTAAAGAAAGGAAGAATGCA
GAGTATAAGAGATACCTAGAGATGCTGCTTGAGTACCTTCAGGATTACACAGATAGAGTG
AAGCCTCTCCAAGATCAGAATGAACTTTTTGGGAAGATTCAGGCTGAGTTTGAGAAGAAA
TGGGAGAATGGGACCTTTCCTGGATGGCCGAAAGAGACAAGCAGTGCCCTGACCCATGCT
GGAGCCCATCTTGACCTCTCTGCATTCTCCTCCTGGGAGGAGTTGGCTTCTCTGGGTTTG
GACAGATTGAAATCTGCTCTCTTAGCTTTAGGCTTGAAATGTGGCGGGACCCTAGAAGAG
CGAGCCCAGAGACTATTCAGTACCAAAGGAAAGTCCCTGGAGTCACTTGATACCTCTTTG
TTTGCCAAAAATCCCAAGTCAAAGGGCACCAAGCGAGACACTGAAAGGAACAAAGACATT
GCTTTTCTAGAAGCCCAGATCTATGAATATGTAGAGATTCTCGGGGAACAGCGACATCTC
ACTCATGAAAATGTACAGCGCAAGCAAGCCAGGACAGGAGAAGAGCGAGAAGAAGAGGAA
GAAGAGCAGATCAGTGAGAGTGAGAGTGAAGATGAAGAGAACGAGATCATTTACAACCCC
AAAAACCTGCCACTTGGCTGGGATGGCAAACCTATTCCCTACTGGCTGTATAAGCTTCAT
GGCCTAAATATCAACTACAACTGTGAGATTTGTGGAAACTACACCTACCGAGGGCCCAAA
GCCTTCCAGCGACACTTTGCTGAATGGCGTCATGCTCATGGCATGAGGTGTTTGGGCATC
CCAAACACTGCTCACTTTGCTAATGTGACACAGATTGAAGATGCTGTCTCCTTGTGGGCC
AAACTGAAATTGCAGAAGGCTTCAGAACGATGGCAGCCTGACACTGAGGAAGAATATGAA
GACTCAAGTGGGAATGTTGTGAATAAGAAGACATACGAGGATCTGAAAAGACAAGGACTG
CTCTAG
Chromosome Location
1
Locus
1p34.3
External Identifiers
ResourceLink
UniProtKB IDQ12874
UniProtKB Entry NameSF3A3_HUMAN
HGNC IDHGNC:10767
General References
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  2. Kramer A, Legrain P, Mulhauser F, Groning K, Brosi R, Bilbe G: Splicing factor SF3a60 is the mammalian homologue of PRP9 of S.cerevisiae: the conserved zinc finger-like motif is functionally exchangeable in vivo. Nucleic Acids Res. 1994 Dec 11;22(24):5223-8. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12695Phenethyl IsothiocyanateinvestigationalunknownDetails