Hyaluronidase-2
Details
- Name
- Hyaluronidase-2
- Synonyms
- 3.2.1.35
- Hyal-2
- Hyaluronoglucosaminidase-2
- LuCa-2
- LUCA2
- Lung carcinoma protein 2
- Gene Name
- HYAL2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052545|Hyaluronidase-2 MRAGPGPTVTLALVLAVSWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAW LWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSR RLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSW ATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDH LQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
- Number of residues
- 473
- Molecular Weight
- 53859.61
- Theoretical pI
- Not Available
- GO Classification
- Functionsenzyme binding / hyaluronic acid binding / hyaluronoglucuronidase activity / hyalurononglucosaminidase activity / receptor signaling protein tyrosine kinase inhibitor activity / receptor tyrosine kinase binding / transcription coactivator activity / transforming growth factor beta binding / virus receptor activityProcessescarbohydrate metabolic process / cartilage development / cellular response to fibroblast growth factor stimulus / cellular response to interleukin-1 / cellular response to transforming growth factor beta stimulus / cellular response to tumor necrosis factor / cellular response to UV-B / defense response to virus / fusion of virus membrane with host plasma membrane / glycosaminoglycan catabolic process / hematopoietic progenitor cell differentiation / hyaluronan catabolic process / kidney development / monocyte activation / multicellular organism aging / multicellular organismal iron ion homeostasis / negative regulation of cell growth / negative regulation of fibroblast migration / negative regulation of MAP kinase activity / negative regulation of protein kinase B signaling / negative regulation of protein tyrosine kinase activity / positive regulation of extrinsic apoptotic signaling pathway / positive regulation of inflammatory response / positive regulation of interleukin-6 production / positive regulation of interleukin-8 production / positive regulation of protein import into nucleus / positive regulation of transcription by RNA polymerase II / positive regulation of urine volume / renal water absorption / response to antibiotic / response to reactive oxygen species / response to virus / skeletal system morphogenesis / transformation of host cell by virus / viral entry into host cellComponentsanchored component of external side of plasma membrane / anchored component of plasma membrane / apical plasma membrane / cell surface / cytoplasm / cytoplasmic vesicle / cytosol / endocytic vesicle / endoplasmic reticulum / Golgi membrane / lysosome / membrane raft / microvillus / perinuclear region of cytoplasm / plasma membrane / RNA polymerase II transcription regulator complex
- General Function
- Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
- Specific Function
- Enzyme binding
- Pfam Domain Function
- Glyco_hydro_56 (PF01630)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052546|Hyaluronidase-2 (HYAL2) ATGCGGGCAGGCCCAGGCCCCACCGTTACATTGGCCCTGGTGCTGGCGGTGTCATGGGCC ATGGAGCTCAAGCCCACAGCACCACCCATCTTCACTGGCCGGCCCTTTGTGGTAGCGTGG GACGTGCCCACACAGGACTGTGGCCCACGCCTCAAGGTGCCACTGGACCTGAATGCCTTT GATGTGCAGGCCTCACCTAATGAGGGTTTTGTGAACCAGAATATTACCATCTTCTACCGC GACCGTCTAGGCCTGTATCCACGCTTCGATTCTGCCGGAAGGTCTGTGCATGGTGGTGTG CCACAGAATGTCAGCCTTTGGGCACACCGGAAGATGCTGCAGAAACGTGTGGAGCACTAC ATTCGGACACAGGAGTCTGCGGGGCTGGCGGTCATCGACTGGGAGGACTGGCGACCTGTG TGGGTGCGCAACTGGCAGGACAAAGATGTGTATCGCCGGTTATCACGCCAGCTAGTGGCC AGTCGTCACCCTGACTGGCCTCCAGACCGCATAGTCAAACAGGCACAATATGAGTTTGAG TTCGCAGCACAGCAGTTCATGCTGGAGACACTGCGTTATGTCAAGGCAGTGCGGCCCCGG CACCTCTGGGGCTTCTACCTCTTTCCTGACTGCTACAATCATGATTATGTGCAGAACTGG GAGAGCTACACAGGCCGCTGCCCTGATGTTGAGGTGGCCCGCAATGACCAGCTGGCCTGG CTGTGGGCTGAGAGCACGGCCCTCTTCCCGTCTGTCTACCTGGACGAGACACTTGCTTCC TCCCGCCATGGCCGCAACTTTGTGAGCTTCCGTGTTCAGGAGGCCCTTCGTGTGGCTCGC ACCCACCATGCCAACCATGCACTCCCAGTCTACGTCTTCACACGACCCACCTACAGCCGC AGGCTCACGGGGCTTAGTGAGATGGACCTCATCTCTACCATTGGCGAGAGTGCGGCCCTG GGCGCAGCTGGTGTCATCCTCTGGGGTGACGCGGGGTACACCACAAGCACGGAGACCTGC CAGTACCTCAAAGATTACCTGACACGGCTGCTGGTCCCCTACGTGGTCAATGTGTCCTGG GCCACCCAATATTGCAGCCGGGCCCAGTGCCATGGCCATGGGCGCTGTGTGCGCCGCAAC CCCAGTGCCAGTACCTTCCTGCATCTCAGCACCAACAGTTTCCGCCTAGTGCCTGGCCAT GCACCTGGTGAACCCCAGCTGCGACCTGTGGGGGAGCTCAGTTGGGCCGACATTGACCAC CTGCAGACACACTTCCGCTGCCAGTGCTACTTGGGCTGGAGTGGTGAGCAATGCCAGTGG GACCATAGGCAGGCAGCTGGAGGTGCCAGCGAGGCCTGGGCTGGGTCCCACCTCACCAGT CTGCTGGCTCTGGCAGCCCTGGCCTTTACCTGGACCTTGTAG
- Chromosome Location
- 3
- Locus
- 3p21.31
- External Identifiers
Resource Link UniProtKB ID Q12891 UniProtKB Entry Name HYAL2_HUMAN HGNC ID HGNC:5321 - General References
- Lepperdinger G, Strobl B, Kreil G: HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity. J Biol Chem. 1998 Aug 28;273(35):22466-70. [Article]
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- Lepperdinger G, Mullegger J, Kreil G: Hyal2--less active, but more versatile? Matrix Biol. 2001 Dec;20(8):509-14. [Article]
- Rai SK, Duh FM, Vigdorovich V, Danilkovitch-Miagkova A, Lerman MI, Miller AD: Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4443-8. [Article]
- Danilkovitch-Miagkova A, Duh FM, Kuzmin I, Angeloni D, Liu SL, Miller AD, Lerman MI: Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4580-5. Epub 2003 Apr 3. [Article]