Pappalysin-1
Details
- Name
- Pappalysin-1
- Synonyms
- 3.4.24.79
- IGF-dependent IGFBP-4 protease
- IGFBP-4ase
- Insulin-like growth factor-dependent IGF-binding protein 4 protease
- PAPP-A
- Pregnancy-associated plasma protein A
- Gene Name
- PAPPA
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049775|Pappalysin-1 MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGPATCATRAARGRRASPP PPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFT LQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRAR QVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLML GGSALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVKHAWSPM KDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQLSSFRQPKVVRYRVVNL YEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWELDVLEVSNSSLRRRLILANCDISKIG DENCDPECNHTLTGHDGGDCRHLRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITN VTQTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMH LGGIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEPSFETGDLC NDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYLD LVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRILV QYASNASSPMPCSPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQG CYLELEFLYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLT IRLWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVAS ILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQC DDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGFL DQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLA QTTFWLRAYFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCR NNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSP AEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQ TGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQL KGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPG YHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRI KCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIGS ECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEP FMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKD LRGYSHG
- Number of residues
- 1627
- Molecular Weight
- 180971.11
- Theoretical pI
- Not Available
- GO Classification
- Functionsmetalloendopeptidase activity / metallopeptidase activity / zinc ion bindingProcessescellular protein metabolic process / female pregnancy / response to follicle-stimulating hormone / response to glucocorticoidComponentsextracellular region / extracellular space
- General Function
- Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
- Specific Function
- Metalloendopeptidase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049776|Pappalysin-1 (PAPPA) ATGCGGCTCTGGAGTTGGGTGCTGCACCTGGGGCTGCTGAGCGCCGCGCTGGGCTGCGGG CTGGCCGAGCGTCCCCGCCGGGCCCGGAGAGACCCGCGGGCCGGCCGACCCCCGCGCCCC GCCGCCGGCCCGGCCACCTGCGCCACCCGGGCGGCCCGCGGCCGCCGCGCCTCGCCGCCG CCGCCGCCGCCGCCGGGCGGTGCCTGGGAAGCCGTGCGCGTCCCCCGGCGGCGGCAGCAG CGGGAGGCGAGGGGCGCCACCGAGGAGCCGAGCCCGCCGAGCCGGGCGCTCTATTTCAGC GGGCGAGGCGAGCAGCTGCGCCTCCGGGCCGACCTCGAGCTGCCCCGGGACGCGTTCACG CTGCAAGTGTGGCTGCGAGCGGAGGGGGGCCAGAGGTCTCCGGCAGTGATCACAGGGCTG TATGACAAATGTTCTTATATCTCACGTGACCGAGGATGGGTCGTGGGCATTCACACCATC AGTGACCAAGACAACAAAGACCCACGCTACTTTTTCTCCTTGAAGACAGACCGAGCCCGG CAAGTGACCACCATCAATGCCCACCGCAGCTACCTCCCAGGCCAGTGGGTATACCTAGCT GCCACCTATGATGGGCAGTTCATGAAGCTCTATGTGAATGGTGCCCAGGTGGCCACCTCT GGGGAACAAGTGGGTGGCATATTCAGCCCACTGACCCAGAAGTGCAAAGTGCTCATGTTA GGGGGCAGTGCCCTGAATCACAACTACCGGGGCTACATCGAGCACTTCAGTCTGTGGAAG GTGGCCAGGACTCAGCGGGAGATACTGTCTGACATGGAAACCCATGGCGCCCACACTGCT CTACCTCAGCTCCTCCTCCAGGAGAACTGGGACAATGTGAAGCATGCCTGGTCCCCCATG AAGGATGGCAGCAGCCCCAAAGTGGAATTCAGCAATGCCCACGGCTTTCTGCTGGACACG AGTCTGGAGCCTCCTCTGTGCGGACAGACATTGTGTGACAACACAGAGGTCATTGCCAGC TACAATCAGCTCTCAAGTTTCCGCCAGCCCAAGGTGGTGCGCTACCGCGTGGTCAACCTC TATGAAGATGATCATAAGAACCCGACGGTGACGCGCGAGCAGGTGGACTTCCAGCACCAT CAGCTGGCTGAGGCCTTCAAGCAATACAACATCTCCTGGGAGCTGGACGTGCTGGAGGTG AGCAACTCCTCCCTTCGCCGCCGCCTCATCCTGGCCAACTGTGACATCAGCAAGATTGGG GATGAGAACTGTGACCCCGAGTGCAACCACACGCTGACGGGCCACGACGGCGGGGATTGC CGCCACCTGCGCCACCCTGCCTTCGTGAAGAAGCAGCACAACGGGGTGTGTGACATGGAC TGCAACTATGAACGGTTCAACTTTGATGGTGGAGAGTGCTGTGACCCTGAAATCACCAAT GTCACTCAGACTTGCTTTGACCCCGACTCTCCACACAGAGCCTACTTGGATGTTAATGAG CTGAAGAACATTCTTAAATTGGATGGATCAACACATCTCAATATTTTCTTTGCAAAATCC TCAGAGGAGGAGTTGGCAGGAGTAGCAACTTGGCCATGGGACAAGGAGGCCCTGATGCAC TTAGGTGGCATTGTCTTGAACCCATCTTTCTATGGCATGCCTGGGCACACCCACACCATG ATCCATGAGATTGGTCACAGCCTGGGCCTCTATCACGTCTTCCGAGGCATCTCAGAAATC CAGTCCTGCAGTGACCCCTGCATGGAGACAGAGCCCTCCTTCGAGACTGGAGACCTCTGC AATGATACCAACCCAGCCCCTAAACACAAGTCCTGTGGTGACCCAGGGCCAGGAAATGAC ACCTGTGGCTTTCATAGCTTCTTCAACACTCCTTACAACAACTTCATGAGCTATGCAGAT GACGACTGTACGGACTCCTTCACGCCCAATCAAGTCGCCAGAATGCACTGTTACCTGGAC CTGGTCTACCAGGGCTGGCAGCCCTCCAGGAAACCAGCGCCTGTTGCCCTCGCCCCCCAA GTTCTGGGCCACACAACGGACTCTGTGACACTGGAGTGGTTCCCACCTATAGATGGCCAT TTCTTTGAAAGAGAATTGGGATCAGCATGTCATCTTTGCCTGGAAGGGAGAATCCTGGTG CAGTATGCTTCCAACGCTTCCTCCCCAATGCCCTGCAGCCCATCAGGACACTGGAGCCCT CGTGAAGCAGAAGGTCATCCTGATGTTGAACAGCCCTGTAAGTCCAGTGTCCGCACCTGG AGCCCAAATTCAGCTGTCAACCCACACACGGTTCCTCCAGCCTGCCCTGAGCCTCAAGGC TGCTACCTCGAGCTGGAGTTCCTCTACCCCTTGGTCCCTGAGTCTCTGACCATTTGGGTG ACCTTTGTCTCCACTGACTGGGACTCTAGTGGAGCTGTCAATGACATCAAACTGTTGGCT GTCAGTGGGAAGAACATCTCCCTGGGTCCTCAGAATGTCTTCTGTGATGTCCCACTGACC ATCAGACTCTGGGACGTGGGCGAGGAGGTGTATGGCATCCAAATCTACACGCTGGATGAG CACCTGGAGATCGATGCTGCCATGTTGACCTCCACTGCAGACACCCCACTCTGTCTACAG TGTAAGCCCCTGAAGTATAAGGTGGTCCGGGACCCTCCTCTCCAGATGGATGTGGCCTCC ATCCTACATCTCAATAGGAAATTCGTAGACATGGATCTAAATCTTGGCAGTGTGTACCAG TATTGGGTCATAACTATTTCAGGAACTGAAGAGAGTGAGCCATCACCTGCTGTCACATAC ATCCATGGAAGTGGGTACTGTGGCGATGGCATTATACAAAAAGACCAAGGTGAACAATGC GACGACATGAATAAGATCAATGGTGATGGCTGCTCCCTTTTCTGCCGACAAGAAGTCTCC TTCAATTGTATTGATGAACCCAGCCGGTGCTATTTCCATGATGGTGATGGGGTATGTGAG GAGTTTGAACAAAAAACCAGCATTAAGGACTGTGGTGTCTACACGCCCCAGGGATTCCTG GATCAGTGGGCATCCAATGCTTCAGTATCTCATCAAGACCAGCAATGCCCAGGCTGGGTC ATCATCGGACAGCCAGCAGCATCCCAGGTGTGTCGAACCAAGGTGATAGATCTCAGTGAA GGCATTTCCCAGCATGCCTGGTACCCTTGCACCATCAGCTACCCATATTCCCAGCTGGCT CAGACCACTTTTTGGCTCCGGGCGTATTTTTCTCAACCAATGGTTGCCGCAGCTGTCATT GTCCACCTGGTGACGGATGGGACATATTATGGGGACCAAAAGCAGGAGACCATCAGCGTG CAGCTGCTTGATACCAAAGATCAGAGCCACGATCTAGGCCTCCATGTCCTGAGCTGCAGG AACAATCCCCTGATTATCCCTGTGGTCCATGACCTCAGCCAGCCCTTCTACCACAGCCAG GCGGTACGTGTGAGCTTCAGTTCGCCCCTGGTCGCCATCTCGGGGGTGGCCCTCCGTTCC TTCGACAACTTTGACCCCGTCACCCTGAGCAGCTGCCAGAGAGGGGAGACCTACAGCCCT GCCGAGCAGAGCTGCGTGCACTTCGCATGTGAGAAAACTGACTGTCCAGAGCTGGCTGTG GAGAATGCTTCTCTCAATTGCTCCAGCAGCGACCGCTACCACGGTGCCCAGTGTACTGTG AGCTGCCGGACAGGCTACGTGCTCCAGATACGGCGGGATGATGAGCTGATCAAGAGCCAG ACGGGACCCAGCGTCACAGTGACCTGTACAGAGGGCAAGTGGAATAAGCAGGTGGCCTGT GAGCCAGTCGACTGCAGCATCCCAGATCACCATCAAGTCTATGCTGCCTCCTTCTCCTGC CCTGAGGGCACCACCTTTGGCAGTCAATGTTCCTTCCAGTGCCGTCACCCTGCACAATTG AAAGGCAACAACAGCCTCCTGACCTGCATGGAGGATGGGCTGTGGTCCTTCCCAGAGGCC CTGTGTGAGCTCATGTGCCTCGCTCCACCCCCTGTGCCCAATGCAGACCTCCAGACCGCC CGGTGCCGAGAGAATAAGCACAAGGTGGGCTCCTTCTGCAAATACAAATGCAAGCCTGGA TACCATGTGCCTGGATCCTCTCGGAAGTCAAAGAAACGGGCCTTCAAGACTCAGTGTACC CAGGATGGCAGCTGGCAGGAGGGAGCTTGTGTTCCTGTGACCTGTGACCCACCTCCACCA AAATTCCATGGGCTCTACCAGTGTACTAATGGCTTCCAGTTCAACAGTGAGTGTAGGATC AAGTGTGAAGACAGTGATGCCTCCCAGGGACTTGGGAGCAATGTCATTCATTGCCGGAAA GATGGCACCTGGAACGGCTCCTTCCATGTCTGCCAGGAGATGCAAGGCCAGTGCTCGGTT CCAAACGAGCTCAACAGCAACCTCAAACTGCAGTGCCCTGATGGCTATGCCATAGGGTCG GAGTGTGCCACCTCGTGCCTGGACCACAACAGCGAGTCCATCATCCTGCCAATGAACGTG ACCGTGCGTGACATCCCCCACTGGCTGAACCCCACACGGGTAGAGAGAGTTGTCTGCACT GCTGGTCTCAAGTGGTATCCTCACCCTGCTCTGATTCACTGTGTCAAAGGCTGTGAGCCC TTCATGGGAGACAATTATTGTGATGCCATCAACAACCGAGCCTTTTGCAACTATGACGGT GGGGATTGCTGCACCTCCACAGTGAAGACCAAAAAGGTCACCCCATTCCCTATGTCCTGT GATCTACAAGGTGACTGTGCTTGTCGGGACCCCCAGGCCCAAGAACACAGCCGGAAAGAC CTCCGGGGATACAGCCATGGCTAA
- Chromosome Location
- 9
- Locus
- 9q33.1
- External Identifiers
Resource Link UniProtKB ID Q13219 UniProtKB Entry Name PAPP1_HUMAN HGNC ID HGNC:8602 - General References
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- Lawrence JB, Oxvig C, Overgaard MT, Sottrup-Jensen L, Gleich GJ, Hays LG, Yates JR 3rd, Conover CA: The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3149-53. [Article]
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- Laursen LS, Overgaard MT, Soe R, Boldt HB, Sottrup-Jensen L, Giudice LC, Conover CA, Oxvig C: Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A. FEBS Lett. 2001 Aug 24;504(1-2):36-40. [Article]
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