Voltage-gated potassium channel subunit beta-2
Details
- Name
- Voltage-gated potassium channel subunit beta-2
- Synonyms
- 1.1.1.-
- hKvbeta2
- K(+) channel subunit beta-2
- KCNA2B
- KCNK2
- Kv-beta-2
- Gene Name
- KCNAB2
- UniProtKB Entry
- Q13303Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052267|Voltage-gated potassium channel subunit beta-2 MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY SKKDYRS
- Number of residues
- 367
- Molecular Weight
- 40999.88
- Theoretical pI
- Not Available
- GO Classification
- Functionspotassium channel regulator activity / voltage-gated potassium channel activityProcessesNADPH oxidation / regulation of potassium ion transmembrane transport / regulation of protein localization to cell surfaceComponentscytoskeleton / cytosol / juxtaparanode region of axon / membrane / pinceau fiber / plasma membrane / specific granule membrane / tertiary granule membrane / voltage-gated potassium channel complex
- General Function
- Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity)
- Specific Function
- aldo-keto reductase (NADPH) activity
- Pfam Domain Function
- Aldo_ket_red (PF00248)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052268|Voltage-gated potassium channel subunit beta-2 (KCNAB2) ATGTATCCAGAATCAACGACGGGCTCCCCGGCTCGGCTCTCGCTGCGGCAGACGGGCTCC CCCGGGATGATCTACAGTACTCGGTATGGGAGTCCCAAAAGACAGCTCCAGTTTTACAGG AACCTGGGCAAGTCTGGCCTGCGGGTCTCCTGCCTGGGACTTGGAACATGGGTGACCTTC GGAGGCCAGATCACCGATGAGATGGCAGAGCAGCTCATGACCTTGGCCTATGATAATGGC ATCAACCTCTTCGATACAGCAGAAGTCTACGCAGCCGGCAAGGCTGAAGTGGTACTGGGA AACATCATTAAGAAGAAAGGATGGAGGCGGTCCAGCCTCGTCATCACCACCAAGATCTTC TGGGGCGGAAAGGCGGAGACGGAGCGGGGCCTGTCCAGGAAGCACATAATCGAAGGTCTG AAAGCTTCCCTGGAGCGACTGCAGCTGGAGTACGTGGATGTGGTGTTTGCCAACCGCCCG GACCCCAACACCCCGATGGAAGAGACCGTCCGCGCCATGACCCACGTCATCAACCAGGGG ATGGCCATGTACTGGGGCACGTCACGCTGGAGCTCCATGGAGATCATGGAGGCCTACTCC GTGGCCCGGCAGTTCAACCTGACCCCGCCCATCTGCGAGCAGGCTGAGTACCACATGTTC CAGCGTGAGAAAGTGGAGGTGCAGCTGCCGGAGCTGTTCCACAAGATAGGAGTGGGCGCC ATGACCTGGTCCCCTCTGGCCTGTGGCATTGTTTCTGGCAAGTACGACAGTGGCATCCCA CCCTACTCAAGAGCCTCCTTGAAGGGCTACCAGTGGCTGAAGGACAAGATCCTCAGTGAG GAGGGCCGGCGCCAGCAAGCCAAGCTGAAGGAGCTGCAGGCCATCGCCGAGCGCCTGGGC TGCACCCTGCCCCAGCTGGCCATAGCCTGGTGCCTGAGGAATGAGGGAGTCAGCTCCGTG CTCCTGGGGGCCTCCAATGCGGACCAGCTCATGGAGAACATTGGGGCAATACAGGTCCTT CCGAAACTGTCATCTTCCATTATCCACGAGATTGATAGTATTTTGGGCAATAAACCCTAC AGCAAAAAGGACTACAGATCCTAA
- Chromosome Location
- 1
- Locus
- 1p36.31
- External Identifiers
Resource Link UniProtKB ID Q13303 UniProtKB Entry Name KCAB2_HUMAN GeneCard ID KCNAB2 HGNC ID HGNC:6229 PDB ID(s) 1ZSX, 7EJ1, 7EJ2, 7WF3, 7WF4 KEGG ID hsa:8514 NCBI Gene ID 8514 - General References
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Associated Data
- Bio-Entities
Bio-Entity Type Voltage-gated potassium channel subunit beta-2 (Humans) protein primaryVoltage-gated Potassium Channels protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Enflurane approved, investigational, vet_approved unknown target inhibitoractivator Details Promethazine approved, investigational unknown target inducer Details Miconazole approved, investigational, vet_approved unknown target inhibitor Details