Voltage-gated potassium channel subunit beta-2

Details

Name
Voltage-gated potassium channel subunit beta-2
Synonyms
  • 1.1.1.-
  • hKvbeta2
  • K(+) channel subunit beta-2
  • KCNA2B
  • KCNK2
  • Kv-beta-2
Gene Name
KCNAB2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052267|Voltage-gated potassium channel subunit beta-2
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
SKKDYRS
Number of residues
367
Molecular Weight
40999.88
Theoretical pI
Not Available
GO Classification
Functions
aldo-keto reductase (NADP) activity / potassium channel regulator activity / voltage-gated potassium channel activity
Processes
hematopoietic progenitor cell differentiation / NADPH oxidation / neuromuscular process / neutrophil degranulation / oxidation-reduction process / regulation of potassium ion transmembrane transport / regulation of protein localization to cell surface
Components
axon terminus / cell junction / cytoskeleton / cytosol / extrinsic component of cytoplasmic side of plasma membrane / juxtaparanode region of axon / membrane / pinceau fiber / plasma membrane / postsynaptic density / specific granule membrane / tertiary granule membrane / voltage-gated potassium channel complex
General Function
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).
Specific Function
Aldo-keto reductase (nadp) activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052268|Voltage-gated potassium channel subunit beta-2 (KCNAB2)
ATGTATCCAGAATCAACGACGGGCTCCCCGGCTCGGCTCTCGCTGCGGCAGACGGGCTCC
CCCGGGATGATCTACAGTACTCGGTATGGGAGTCCCAAAAGACAGCTCCAGTTTTACAGG
AACCTGGGCAAGTCTGGCCTGCGGGTCTCCTGCCTGGGACTTGGAACATGGGTGACCTTC
GGAGGCCAGATCACCGATGAGATGGCAGAGCAGCTCATGACCTTGGCCTATGATAATGGC
ATCAACCTCTTCGATACAGCAGAAGTCTACGCAGCCGGCAAGGCTGAAGTGGTACTGGGA
AACATCATTAAGAAGAAAGGATGGAGGCGGTCCAGCCTCGTCATCACCACCAAGATCTTC
TGGGGCGGAAAGGCGGAGACGGAGCGGGGCCTGTCCAGGAAGCACATAATCGAAGGTCTG
AAAGCTTCCCTGGAGCGACTGCAGCTGGAGTACGTGGATGTGGTGTTTGCCAACCGCCCG
GACCCCAACACCCCGATGGAAGAGACCGTCCGCGCCATGACCCACGTCATCAACCAGGGG
ATGGCCATGTACTGGGGCACGTCACGCTGGAGCTCCATGGAGATCATGGAGGCCTACTCC
GTGGCCCGGCAGTTCAACCTGACCCCGCCCATCTGCGAGCAGGCTGAGTACCACATGTTC
CAGCGTGAGAAAGTGGAGGTGCAGCTGCCGGAGCTGTTCCACAAGATAGGAGTGGGCGCC
ATGACCTGGTCCCCTCTGGCCTGTGGCATTGTTTCTGGCAAGTACGACAGTGGCATCCCA
CCCTACTCAAGAGCCTCCTTGAAGGGCTACCAGTGGCTGAAGGACAAGATCCTCAGTGAG
GAGGGCCGGCGCCAGCAAGCCAAGCTGAAGGAGCTGCAGGCCATCGCCGAGCGCCTGGGC
TGCACCCTGCCCCAGCTGGCCATAGCCTGGTGCCTGAGGAATGAGGGAGTCAGCTCCGTG
CTCCTGGGGGCCTCCAATGCGGACCAGCTCATGGAGAACATTGGGGCAATACAGGTCCTT
CCGAAACTGTCATCTTCCATTATCCACGAGATTGATAGTATTTTGGGCAATAAACCCTAC
AGCAAAAAGGACTACAGATCCTAA
Chromosome Location
1
Locus
1p36.31
External Identifiers
ResourceLink
UniProtKB IDQ13303
UniProtKB Entry NameKCAB2_HUMAN
HGNC IDHGNC:6229
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00228Enfluraneapproved, investigational, vet_approvedunknowninhibitoractivatorDetails
DB01069Promethazineapproved, investigationalunknowninducerDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails