Voltage-gated potassium channel subunit beta-2

Details

Name
Voltage-gated potassium channel subunit beta-2
Synonyms
  • 1.1.1.-
  • hKvbeta2
  • K(+) channel subunit beta-2
  • KCNA2B
  • KCNK2
  • Kv-beta-2
Gene Name
KCNAB2
UniProtKB Entry
Q13303Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0052267|Voltage-gated potassium channel subunit beta-2
MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
SKKDYRS
Number of residues
367
Molecular Weight
40999.88
Theoretical pI
Not Available
GO Classification
Functions
potassium channel regulator activity / voltage-gated potassium channel activity
Processes
NADPH oxidation / regulation of potassium ion transmembrane transport / regulation of protein localization to cell surface
Components
cytoskeleton / cytosol / juxtaparanode region of axon / membrane / pinceau fiber / plasma membrane / specific granule membrane / tertiary granule membrane / voltage-gated potassium channel complex
General Function
Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:11825900, PubMed:7649300). The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:11825900, PubMed:7649300). Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:11825900, PubMed:7649300). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates (By similarity). Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet) (By similarity). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity)
Specific Function
aldo-keto reductase (NADPH) activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0052268|Voltage-gated potassium channel subunit beta-2 (KCNAB2)
ATGTATCCAGAATCAACGACGGGCTCCCCGGCTCGGCTCTCGCTGCGGCAGACGGGCTCC
CCCGGGATGATCTACAGTACTCGGTATGGGAGTCCCAAAAGACAGCTCCAGTTTTACAGG
AACCTGGGCAAGTCTGGCCTGCGGGTCTCCTGCCTGGGACTTGGAACATGGGTGACCTTC
GGAGGCCAGATCACCGATGAGATGGCAGAGCAGCTCATGACCTTGGCCTATGATAATGGC
ATCAACCTCTTCGATACAGCAGAAGTCTACGCAGCCGGCAAGGCTGAAGTGGTACTGGGA
AACATCATTAAGAAGAAAGGATGGAGGCGGTCCAGCCTCGTCATCACCACCAAGATCTTC
TGGGGCGGAAAGGCGGAGACGGAGCGGGGCCTGTCCAGGAAGCACATAATCGAAGGTCTG
AAAGCTTCCCTGGAGCGACTGCAGCTGGAGTACGTGGATGTGGTGTTTGCCAACCGCCCG
GACCCCAACACCCCGATGGAAGAGACCGTCCGCGCCATGACCCACGTCATCAACCAGGGG
ATGGCCATGTACTGGGGCACGTCACGCTGGAGCTCCATGGAGATCATGGAGGCCTACTCC
GTGGCCCGGCAGTTCAACCTGACCCCGCCCATCTGCGAGCAGGCTGAGTACCACATGTTC
CAGCGTGAGAAAGTGGAGGTGCAGCTGCCGGAGCTGTTCCACAAGATAGGAGTGGGCGCC
ATGACCTGGTCCCCTCTGGCCTGTGGCATTGTTTCTGGCAAGTACGACAGTGGCATCCCA
CCCTACTCAAGAGCCTCCTTGAAGGGCTACCAGTGGCTGAAGGACAAGATCCTCAGTGAG
GAGGGCCGGCGCCAGCAAGCCAAGCTGAAGGAGCTGCAGGCCATCGCCGAGCGCCTGGGC
TGCACCCTGCCCCAGCTGGCCATAGCCTGGTGCCTGAGGAATGAGGGAGTCAGCTCCGTG
CTCCTGGGGGCCTCCAATGCGGACCAGCTCATGGAGAACATTGGGGCAATACAGGTCCTT
CCGAAACTGTCATCTTCCATTATCCACGAGATTGATAGTATTTTGGGCAATAAACCCTAC
AGCAAAAAGGACTACAGATCCTAA
Chromosome Location
1
Locus
1p36.31
External Identifiers
ResourceLink
UniProtKB IDQ13303
UniProtKB Entry NameKCAB2_HUMAN
GeneCard IDKCNAB2
HGNC IDHGNC:6229
PDB ID(s)1ZSX, 7EJ1, 7EJ2, 7WF3, 7WF4
KEGG IDhsa:8514
NCBI Gene ID8514
General References
  1. McCormack K, McCormack T, Tanouye M, Rudy B, Stuhmer W: Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. FEBS Lett. 1995 Aug 14;370(1-2):32-6. doi: 10.1016/0014-5793(95)00785-8. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Voltage-gated potassium channel subunit beta-2 (Humans)protein
primary
Voltage-gated Potassium Channelsprotein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Enfluraneapproved, investigational, vet_approvedunknowntargetinhibitoractivatorDetails
Promethazineapproved, investigationalunknowntargetinducerDetails
Miconazoleapproved, investigational, vet_approvedunknowntargetinhibitorDetails