Uracil nucleotide/cysteinyl leukotriene receptor
Details
- Name
- Uracil nucleotide/cysteinyl leukotriene receptor
- Synonyms
- G-protein coupled receptor 17
- P2Y-like receptor
- R12
- UDP/CysLT receptor
- Gene Name
- GPR17
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052742|Uracil nucleotide/cysteinyl leukotriene receptor MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS LSAKSEL
- Number of residues
- 367
- Molecular Weight
- 40988.99
- Theoretical pI
- Not Available
- GO Classification
- Functionschemokine receptor activity / G protein-coupled receptor activityProcessesG protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway / positive regulation of Rho protein signal transductionComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
- Specific Function
- Chemokine receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 65-85 93-113 134-154 176-196 224-244 261-281 309-329
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052743|Uracil nucleotide/cysteinyl leukotriene receptor (GPR17) ATGTCCAAACGGAGTTGGTGGGCTGGATCCAGAAAGCCCCCAAGAGAGATGCTGAAACTC TCAGGCTCTGACTCCAGCCAAAGCATGAATGGCCTTGAAGTGGCTCCCCCAGGTCTGATC ACCAACTTCTCCCTGGCCACGGCAGAGCAATGTGGCCAGGAGACGCCACTGGAGAACATG CTGTTCGCCTCCTTCTACCTTCTGGATTTTATCCTGGCTTTAGTTGGCAATACCCTGGCT CTGTGGCTTTTCATCCGAGACCACAAGTCCGGGACCCCGGCCAACGTGTTCCTGATGCAT CTGGCCGTGGCCGACTTGTCGTGCGTGCTGGTCCTGCCCACCCGCCTGGTCTACCACTTC TCTGGGAACCACTGGCCATTTGGGGAAATCGCATGCCGTCTCACCGGCTTCCTCTTCTAC CTCAACATGTACGCCAGCATCTACTTCCTCACCTGCATCAGCGCCGACCGTTTCCTGGCC ATTGTGCACCCGGTCAAGTCCCTCAAGCTCCGCAGGCCCCTCTACGCACACCTGGCCTGT GCCTTCCTGTGGGTGGTGGTGGCTGTGGCCATGGCCCCGCTGCTGGTGAGCCCACAGACC GTGCAGACCAACCACACGGTGGTCTGCCTGCAGCTGTACCGGGAGAAGGCCTCCCACCAT GCCCTGGTGTCCCTGGCAGTGGCCTTCACCTTCCCGTTCATCACCACGGTCACCTGCTAC CTGCTGATCATCCGCAGCCTGCGGCAGGGCCTGCGTGTGGAGAAGCGCCTCAAGACCAAG GCAGTGCGCATGATCGCCATAGTGCTGGCCATCTTCCTGGTCTGCTTCGTGCCCTACCAC GTCAACCGCTCCGTCTACGTGCTGCACTACCGCAGCCATGGGGCCTCCTGCGCCACCCAG CGCATCCTGGCCCTGGCAAACCGCATCACCTCCTGCCTCACCAGCCTCAACGGGGCACTC GACCCCATCATGTATTTCTTCGTGGCTGAGAAGTTCCGCCACGCCCTGTGCAACTTGCTC TGTGGCAAAAGGCTCAAGGGCCCGCCCCCCAGCTTCGAAGGGAAAACCAACGAGAGCTCG CTGAGTGCCAAGTCAGAGCTGTGA
- Chromosome Location
- 2
- Locus
- 2q14.3
- External Identifiers
Resource Link UniProtKB ID Q13304 UniProtKB Entry Name GPR17_HUMAN HGNC ID HGNC:4471 - General References
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