Urea transporter 1
Details
- Name
- Urea transporter 1
- Synonyms
- HUT11
- JK
- RACH1
- Solute carrier family 14 member 1
- Urea transporter, erythrocyte
- UT1
- UTE
- Gene Name
- SLC14A1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008543|Urea transporter 1 MEDSPTMVRVDSPTMVRGENQVSPCQGRRCFPKALGYVTGDMKELANQLKDKPVVLQFID WILRGISQVVFVNNPVSGILILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASG LYGYNATLVGVLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSMLSKWDLPVFTLPF NMALSMYLSATGHYNPFFPAKLVIPITTAPNISWSDLSALELLKSIPVGVGQIYGCDNPW TGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEDIYFGLWGFNSSLACIAMGGM FMALTWQTHLLALGCALFTAYLGVGMANFMAEVGLPACTWPFCLATLLFLIMTTKNSNIY KMPLSKVTYPEENRIFYLQAKKRMVESPL
- Number of residues
- 389
- Molecular Weight
- 42527.93
- Theoretical pI
- Not Available
- GO Classification
- Functionsurea channel activity / water transmembrane transporter activityProcessestransmembrane transport / urea transmembrane transport / urea transportComponentsbasolateral plasma membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / nucleolus / plasma membrane
- General Function
- Water transmembrane transporter activity
- Specific Function
- Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- 91-110 115-137 144-168 173-193 255-274 284-304 309-330 333-353
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017512|Urea transporter 1 (SLC14A1) ATGAATGGACGGTCTTTGATTGGCGGCGCTGGTGACGCCCGTCATGGTCCTGTTTGGAAG GACCCTTTTGGAACTAAAGCTGGTGACGCAGCGCGCAGAGGCATCGCCCGGCTAAGCTTG GCCCTGGCAGATGGGTCGCAGGAACAGGAGCCAGAGGAAGAGATAGCCATGGAGGACAGC CCCACTATGGTTAGAGTGGACAGCCCCACTATGGTTAGGGGTGAAAACCAGGTTTCGCCA TGTCAAGGGAGAAGGTGCTTCCCCAAAGCTCTTGGCTATGTCACCGGTGACATGAAAGAA CTTGCCAACCAGCTTAAAGACAAACCCGTGGTGCTCCAGTTCATTGACTGGATTCTCCGG GGCATATCCCAAGTGGTGTTCGTCAACAACCCCGTCAGTGGAATCCTGATTCTGGTAGGA CTTCTTGTTCAGAACCCCTGGTGGGCTCTCACTGGCTGGCTGGGAACAGTGGTCTCCACT CTGATGGCCCTCTTGCTCAGCCAGGACAGGTCATTAATAGCATCTGGGCTCTATGGCTAC AATGCCACCCTGGTGGGAGTACTCATGGCTGTCTTTTCGGACAAGGGAGACTATTTCTGG TGGCTGTTACTCCCTGTATGTGCTATGTCCATGACTTGCCCAATTTTCTCAAGTGCATTG AATTCCATGCTCAGCAAATGGGACCTCCCCGTCTTCACCCTCCCTTTCAACATGGCGTTG TCAATGTACCTTTCAGCCACAGGACATTACAATCCATTCTTTCCAGCCAAACTGGTCATA CCTATAACTACAGCTCCAAATATCTCCTGGTCTGACCTCAGTGCCCTGGAGTTGTTGAAA TCTATACCAGTGGGAGTTGGTCAGATCTATGGCTGTGATAATCCATGGACAGGGGGCATT TTCCTGGGAGCCATCCTACTCTCCTCCCCACTCATGTGCCTGCATGCTGCCATAGGATCA TTGCTGGGCATAGCAGCGGGACTCAGTCTTTCAGCCCCATTTGAGGACATCTACTTTGGA CTCTGGGGTTTCAACAGCTCTCTGGCCTGCATTGCAATGGGAGGAATGTTCATGGCGCTC ACCTGGCAAACCCACCTCCTGGCTCTTGGCTGTGCCCTGTTCACGGCCTATCTTGGAGTC GGCATGGCAAACTTTATGGCTGAGGTTGGATTGCCAGCTTGTACCTGGCCCTTCTGTTTG GCCACGCTATTGTTCCTCATCATGACCACAAAAAATTCCAACATCTACAAGATGCCCCTC AGTAAAGTTACTTATCCTGAAGAAAACCGCATCTTCTACCTGCAAGCCAAGAAAAGAATG GTGGAAAGCCCTTTGTGA
- Chromosome Location
- 18
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q13336 UniProtKB Entry Name UT1_HUMAN HGNC ID HGNC:10918 - General References
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