Disintegrin and metalloproteinase domain-containing protein 9
Details
- Name
- Disintegrin and metalloproteinase domain-containing protein 9
- Synonyms
- 3.4.24.-
- ADAM 9
- Cellular disintegrin-related protein
- KIAA0021
- MCMP
- MDC9
- Meltrin-gamma
- Metalloprotease/disintegrin/cysteine-rich protein 9
- MLTNG
- Myeloma cell metalloproteinase
- Gene Name
- ADAM9
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006659|Disintegrin and metalloproteinase domain-containing protein 9 MGSGARFPSGTLRVRWLLLLGLVGPVLGAARPGFQQTSHLSSYEIITPWRLTRERREAPR PYSKQVSYVIQAEGKEHIIHLERNKDLLPEDFVVYTYNKEGTLITDHPNIQNHCHYRGYV EGVHNSSIALSDCFGLRGLLHLENASYGIEPLQNSSHFEHIIYRMDDVYKEPLKCGVSNK DIEKETAKDEEEEPPSMTQLLRRRRAVLPQTRYVELFIVVDKERYDMMGRNQTAVREEMI LLANYLDSMYIMLNIRIVLVGLEIWTNGNLINIVGGAGDVLGNFVQWREKFLITRRRHDS AQLVLKKGFGGTAGMAFVGTVCSRSHAGGINVFGQITVETFASIVAHELGHNLGMNHDDG RDCSCGAKSCIMNSGASGSRNFSSCSAEDFEKLTLNKGGNCLLNIPKPDEAYSAPSCGNK LVDAGEECDCGTPKECELDPCCEGSTCKLKSFAECAYGDCCKDCRFLPGGTLCRGKTSEC DVPEYCNGSSQFCQPDVFIQNGYPCQNNKAYCYNGMCQYYDAQCQVIFGSKAKAAPKDCF IEVNSKGDRFGNCGFSGNEYKKCATGNALCGKLQCENVQEIPVFGIVPAIIQTPSRGTKC WGVDFQLGSDVPDPGMVNEGTKCGAGKICRNFQCVDASVLNYDCDVQKKCHGHGVCNSNK NCHCENGWAPPNCETKGYGGSVDSGPTYNEMNTALRDGLLVFFFLIVPLIVCAIFIFIKR DQLWRSYFRKKRSQTYESDGKNQANPSRQPGSVPRHVSPVTPPREVPIYANRFAVPTYAA KQPQQFPSRPPPPQPKVSSQGNLIPARPAPAPPLYSSLT
- Number of residues
- 819
- Molecular Weight
- 90555.29
- Theoretical pI
- 7.55
- GO Classification
- Functionscollagen binding / integrin binding / laminin binding / metalloendopeptidase activity / metallopeptidase activity / protein kinase C binding / SH3 domain binding / zinc ion bindingProcessesactivation of MAPKK activity / cell adhesion / cell adhesion mediated by integrin / cell-cell adhesion mediated by integrin / cell-matrix adhesion / cellular response to lipopolysaccharide / collagen catabolic process / extracellular matrix disassembly / extracellular matrix organization / integrin-mediated signaling pathway / keratinocyte differentiation / membrane protein ectodomain proteolysis / monocyte activation / PMA-inducible membrane protein ectodomain proteolysis / positive regulation of cell adhesion mediated by integrin / positive regulation of keratinocyte migration / positive regulation of macrophage fusion / positive regulation of membrane protein ectodomain proteolysis / positive regulation of protein secretion / response to calcium ion / response to glucocorticoid / response to hydrogen peroxide / response to manganese ion / response to tumor necrosis factor / transforming growth factor beta receptor signaling pathwayComponentscell surface / cytoplasm / extracellular exosome / extracellular space / focal adhesion / integral component of membrane / intrinsic component of external side of plasma membrane
- General Function
- Zinc ion binding
- Specific Function
- Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.
- Pfam Domain Function
- Transmembrane Regions
- 698-718
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017094|Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9) ATGGGGTCTGGCGCGCGCTTTCCCTCGGGGACCCTTCGTGTCCGGTGGTTGCTGTTGCTT GGCCTGGTGGGCCCAGTCCTCGGTGCGGCGCGGCCAGGCTTTCAACAGACCTCACATCTT TCTTCTTATGAAATTATAACTCCTTGGAGATTAACTAGAGAAAGAAGAGAAGCCCCTAGG CCCTATTCAAAACAAGTATCTTATGTTATTCAGGCTGAAGGAAAAGAGCATATTATTCAC TTGGAAAGGAACAAAGACCTTTTGCCTGAAGATTTTGTGGTTTATACTTACAACAAGGAA GGGACTTTAATCACTGACCATCCCAATATACAGAATCATTGTCATTATCGGGGCTATGTG GAGGGAGTTCATAATTCATCCATTGCTCTTAGCGACTGTTTTGGACTCAGAGGATTGCTG CATTTAGAGAATGCGAGTTATGGGATTGAACCCCTGCAGAACAGCTCTCATTTTGAGCAC ATCATTTATCGAATGGATGATGTCTACAAAGAGCCTCTGAAATGTGGAGTTTCCAACAAG GATATAGAGAAAGAAACTGCAAAGGATGAAGAGGAAGAGCCTCCCAGCATGACTCAGCTA CTTCGAAGAAGAAGAGCTGTCTTGCCACAGACCCGGTATGTGGAGCTGTTCATTGTCGTA GACAAGGAAAGGTATGACATGATGGGAAGAAATCAGACTGCTGTGAGAGAAGAGATGATT CTCCTGGCAAACTACTTGGATAGTATGTATATTATGTTAAATATTCGAATTGTGCTAGTT GGACTGGAGATTTGGACCAATGGAAACCTGATCAACATAGTTGGGGGTGCTGGTGATGTG CTGGGGAACTTCGTGCAGTGGCGGGAAAAGTTTCTTATCACACGTCGGAGACATGACAGT GCACAGCTAGTTCTAAAGAAAGGTTTTGGTGGAACTGCAGGAATGGCATTTGTGGGAACA GTGTGTTCAAGGAGCCACGCAGGCGGGATTAATGTGTTTGGACAAATCACTGTGGAGACA TTTGCTTCCATTGTTGCTCATGAATTGGGTCATAATCTTGGAATGAATCACGATGATGGG AGAGATTGTTCCTGTGGAGCAAAGAGCTGCATCATGAATTCAGGAGCATCGGGTTCCAGA AACTTTAGCAGTTGCAGTGCAGAGGACTTTGAGAAGTTAACTTTAAATAAAGGAGGAAAC TGCCTTCTTAATATTCCAAAGCCTGATGAAGCCTATAGTGCTCCCTCCTGTGGTAATAAG TTGGTGGACGCTGGGGAAGAGTGTGACTGTGGTACTCCAAAGGAATGTGAATTGGACCCT TGCTGCGAAGGAAGTACCTGTAAGCTTAAATCATTTGCTGAGTGTGCATATGGTGACTGT TGTAAAGACTGTCGGTTCCTTCCAGGAGGTACTTTATGCCGAGGAAAAACCAGTGAGTGT GATGTTCCAGAGTACTGCAATGGTTCTTCTCAGTTCTGTCAGCCAGATGTTTTTATTCAG AATGGATATCCTTGCCAGAATAACAAAGCCTATTGCTACAACGGCATGTGCCAGTATTAT GATGCTCAATGTCAAGTCATCTTTGGCTCAAAAGCCAAGGCTGCCCCCAAAGATTGTTTC ATTGAAGTGAATTCTAAAGGTGACAGATTTGGCAATTGTGGTTTCTCTGGCAATGAATAC AAGAAGTGTGCCACTGGGAATGCTTTGTGTGGAAAGCTTCAGTGTGAGAATGTACAAGAG ATACCTGTATTTGGAATTGTGCCTGCTATTATTCAAACGCCTAGTCGAGGCACCAAATGT TGGGGTGTGGATTTCCAGCTAGGATCAGATGTTCCAGATCCTGGGATGGTTAACGAAGGC ACAAAATGTGGTGCTGGAAAGATCTGTAGAAACTTCCAGTGTGTAGATGCTTCTGTTCTG AATTATGACTGTGATGTTCAGAAAAAGTGTCATGGACATGGGGTATGTAATAGCAATAAG AATTGTCACTGTGAAAATGGCTGGGCTCCCCCAAATTGTGAGACTAAAGGATACGGAGGA AGTGTGGACAGTGGACCTACATACAATGAAATGAATACTGCATTGAGGGACGGACTTCTG GTCTTCTTCTTCCTAATTGTTCCCCTTATTGTCTGTGCTATTTTTATCTTCATCAAGAGG GATCAACTGTGGAGAAGCTACTTCAGAAAGAAGAGATCACAAACATATGAGTCAGATGGC AAAAATCAAGCAAACCCTTCTAGACAGCCGGGGAGTGTTCCTCGACATGTTTCTCCAGTG ACACCTCCCAGAGAAGTTCCTATATATGCAAACAGATTTGCAGTACCAACCTATGCAGCC AAGCAACCTCAGCAGTTCCCATCAAGGCCACCTCCACCACAACCGAAAGTATCATCTCAG GGAAACTTAATTCCTGCCCGTCCTGCTCCTGCACCTCCTTTATATAGTTCCCTCACTTGA
- Chromosome Location
- 8
- Locus
- 8p11.23
- External Identifiers
Resource Link UniProtKB ID Q13443 UniProtKB Entry Name ADAM9_HUMAN GenBank Gene ID U41766 GenAtlas ID ADAM9 HGNC ID HGNC:216 - General References
- Weskamp G, Kratzschmar J, Reid MS, Blobel CP: MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J Cell Biol. 1996 Feb;132(4):717-26. [Article]
- McKie N, Dallas DJ, Edwards T, Apperley JF, Russell RG, Croucher PI: Cloning of a novel membrane-linked metalloproteinase from human myeloma cells. Biochem J. 1996 Sep 1;318 ( Pt 2):459-62. [Article]
- Hotoda N, Koike H, Sasagawa N, Ishiura S: A secreted form of human ADAM9 has an alpha-secretase activity for APP. Biochem Biophys Res Commun. 2002 May 3;293(2):800-5. [Article]
- Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1994;1(1):27-35. [Article]
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- McKie N, Edwards T, Dallas DJ, Houghton A, Stringer B, Graham R, Russell G, Croucher PI: Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes. Biochem Biophys Res Commun. 1997 Jan 13;230(2):335-9. [Article]
- Howard L, Nelson KK, Maciewicz RA, Blobel CP: Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. J Biol Chem. 1999 Oct 29;274(44):31693-9. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Parry DA, Toomes C, Bida L, Danciger M, Towns KV, McKibbin M, Jacobson SG, Logan CV, Ali M, Bond J, Chance R, Swendeman S, Daniele LL, Springell K, Adams M, Johnson CA, Booth AP, Jafri H, Rashid Y, Banin E, Strom TM, Farber DB, Sharon D, Blobel CP, Pugh EN Jr, Pierce EA, Inglehearn CF: Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice. Am J Hum Genet. 2009 May;84(5):683-91. doi: 10.1016/j.ajhg.2009.04.005. Epub 2009 Apr 30. [Article]