Non-receptor tyrosine-protein kinase TNK1

Details

Name
Non-receptor tyrosine-protein kinase TNK1
Synonyms
  • 2.7.10.2
  • CD38 negative kinase 1
Gene Name
TNK1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051678|Non-receptor tyrosine-protein kinase TNK1
MLPEAGSLWLLKLLRDIQLAQFYWPILEELNVTRPEHFDFVKPEDLDGIGMGRPAQRRLS
EALKRLRSGPKSKNWVYKILGGFAPEHKEPTLPSDSPRHLPEPEGGLKCLIPEGAVCRGE
LLGSGCFGVVHRGLWTLPSGKSVPVAVKSLRVGPEGPMGTELGDFLREVSVMMNLEHPHV
LRLHGLVLGQPLQMVMELAPLGSLHARLTAPAPTPPLLVALLCLFLRQLAGAMAYLGARG
LVHRDLATRNLLLASPRTIKVADFGLVRPLGGARGRYVMGGPRPIPYAWCAPESLRHGAF
SSASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEDRARLPRPPLCSRALYSLALRCW
APHPADRPSFSHLEGLLQEAGPSEACCVRDVTEPGALRMETGDPITVIEGSSSFHSPDST
IWKGQNGRTFKVGSFPASAVTLADAGGLPATRPVHRGTPARGDQHPGSIDGDRKKANLWD
APPARGQRRNMPLERMKGISRSLESVLSLGPRPTGGGSSPPEIRQARAVPQGPPGLPPRP
PLSSSSPQPSQPSRERLPWPKRKPPHNHPMGMPGARKAAALSGGLLSDPELQRKIMEVEL
SVHGVTHQECQTALGATGGDVVSAIRNLKVDQLFHLSSRSRADCWRILEHYQWDLSAASR
YVLARP
Number of residues
666
Molecular Weight
72466.995
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / non-membrane spanning protein tyrosine kinase activity / protein tyrosine kinase activity / receptor binding / signal transducer activity
Processes
cell differentiation / cell migration / innate immune response / negative regulation of cell growth / negative regulation of Ras protein signal transduction / peptidyl-tyrosine autophosphorylation / protein autophosphorylation / protein phosphorylation / regulation of cell proliferation / transmembrane receptor protein tyrosine kinase signaling pathway
Components
cytoplasm / cytosol / extrinsic component of cytoplasmic side of plasma membrane / membrane
General Function
Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051679|Non-receptor tyrosine-protein kinase TNK1 (TNK1)
ATGCTTCCTGAGGCTGGCTCCCTGTGGCTACTGAAGCTGCTCCGGGACATCCAGTTGGCC
CAGTTTTACTGGCCCATCCTTGAGGAGCTTAATGTCACTCGGCCAGAGCACTTCGACTTT
GTAAAGCCTGAGGACCTGGACGGCATTGGCATGGGCCGGCCTGCCCAGCGCAGACTGTCC
GAAGCTCTGAAAAGGCTACGTTCTGGGCCTAAGTCTAAGAACTGGGTCTACAAGATCCTT
GGAGGTTTTGCCCCTGAGCACAAGGAGCCCACCCTGCCCTCGGACAGCCCACGGCACCTC
CCTGAGCCAGAGGGGGGCCTCAAGTGTCTGATCCCAGAGGGTGCTGTTTGCAGAGGGGAG
CTGCTGGGTTCAGGCTGCTTCGGTGTGGTGCACCGAGGGCTGTGGACGCTGCCCAGTGGC
AAGAGTGTCCCAGTGGCTGTCAAGTCCCTCCGGGTAGGTCCCGAAGGCCCGATGGGCACA
GAACTGGGGGACTTCCTGCGAGAGGTATCGGTCATGATGAACTTGGAGCACCCACACGTG
CTGCGTCTGCACGGCCTTGTACTGGGCCAGCCTCTGCAGATGGTGATGGAGCTGGCGCCA
CTGGGCTCCCTGCACGCGCGCCTAACGGCCCCGGCCCCGACACCCCCGCTGCTCGTGGCC
CTGCTCTGCCTCTTCCTGCGGCAGCTGGCGGGAGCCATGGCGTACCTGGGGGCCCGCGGG
CTGGTGCACCGAGACCTCGCTACGCGCAACCTACTGCTGGCGTCGCCGCGCACCATCAAG
GTGGCTGACTTCGGGCTGGTGCGGCCTCTGGGCGGTGCCCGGGGCCGCTACGTCATGGGC
GGGCCCCGCCCTATCCCCTACGCCTGGTGTGCCCCAGAGAGCCTGCGCCACGGAGCCTTC
TCGTCTGCCTCGGACGTGTGGATGTTTGGGGTGACGCTGTGGGAGATGTTCTCCGGGGGC
GAGGAACCCTGGGCCGGGGTCCCACCGTACCTCATCCTGCAGCGGCTGGAGGACAGAGCC
CGGCTGCCTAGGCCTCCCCTCTGCTCCAGGGCCCTCTACTCCCTCGCCTTGCGCTGCTGG
GCCCCCCACCCTGCCGACCGGCCTAGCTTTTCCCACCTGGAGGGGCTGCTGCAAGAGGCC
GGGCCTTCGGAAGCATGTTGTGTGAGGGATGTCACAGAACCAGGCGCCCTGAGGATGGAG
ACTGGTGACCCCATCACAGTCATCGAGGGCAGCTCCTCTTTCCACAGCCCCGACTCCACA
ATCTGGAAGGGCCAGAATGGTCGCACCTTCAAAGTGGGCAGCTTCCCAGCCTCGGCAGTG
ACGCTGGCAGATGCGGGGGGCTTGCCAGCCACCCGTCCAGTCCACAGAGGCACCCCTGCC
CGGGGAGATCAACACCCAGGAAGCATAGATGGAGACAGAAAGAAGGCAAATCTTTGGGAT
GCGCCCCCAGCACGGGGCCAGAGGAGGAACATGCCCCTGGAGAGGATGAAAGGCATTTCC
AGGAGTCTGGAGTCAGTTCTGTCCCTCGGTCCTCGTCCCACAGGGGGTGGTTCAAGCCCC
CCTGAAATTCGACAAGCCAGAGCTGTGCCCCAGGGACCTCCAGGCCTGCCTCCACGCCCA
CCTTTATCCTCTAGCTCTCCTCAGCCCAGCCAGCCCTCTAGGGAGAGGCTTCCCTGGCCC
AAAAGAAAACCCCCACACAATCACCCCATGGGAATGCCTGGAGCCCGTAAAGCCGCTGCC
CTCTCTGGAGGCCTCTTGTCCGATCCTGAGTTGCAGAGGAAGATTATGGAGGTGGAGCTG
AGTGTGCATGGGGTCACCCACCAGGAGTGCCAGACAGCACTAGGAGCCACTGGGGGAGAT
GTGGTTTCTGCCATCCGGAACCTCAAGGTAGATCAGCTCTTCCACCTGAGTAGCCGGTCC
AGAGCTGACTGCTGGCGCATCCTGGAGCATTACCAGTGGGACCTCTCAGCTGCCAGCCGC
TATGTCCTGGCCAGGCCCTGA
Chromosome Location
17
Locus
17p13.1
External Identifiers
ResourceLink
UniProtKB IDQ13470
UniProtKB Entry NameTNK1_HUMAN
HGNC IDHGNC:11940
General References
  1. Hoehn GT, Stokland T, Amin S, Ramirez M, Hawkins AL, Griffin CA, Small D, Civin CI: Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells. Oncogene. 1996 Feb 15;12(4):903-13. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Felschow DM, Civin CI, Hoehn GT: Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Biochem Biophys Res Commun. 2000 Jun 24;273(1):294-301. [Article]
  4. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
  5. Hoare S, Hoare K, Reinhard MK, Lee YJ, Oh SP, May WS Jr: Tnk1/Kos1 knockout mice develop spontaneous tumors. Cancer Res. 2008 Nov 1;68(21):8723-32. doi: 10.1158/0008-5472.CAN-08-1467. [Article]
  6. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
  7. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  8. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [Article]
  9. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  10. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
  11. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
  12. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  13. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails